Iron and Pain
in [Lupus]
|
From: ironjustice on 2 Aug 2008 11:23 http://www.chemheritage.org/educationalservices/pharm/tg/asp/asp120.htm After Columbus, Europeans began to use quinine from Peru for killing pain. But during the Napoleonic Wars, Britain's Royal Navy blockaded mainland Europe, cutting it off from its quinine supply. http://www.scielo.br/scielo.php?pid=S0103-50532006000300010&script=sci_arttext The capacity of quinine and related drugs to interact with iron seems to be relevant. Just thought I'd remind anyone interested .. the role of elevated iron levels as the root cause of medical problems. Med Hypotheses 1998 Mar;50(3):239-51 A chelate theory for the mechanism of action of aspirin-like drugs. Wang X Department of Pathology, Cornell University Medical College, New York, NY 10021, USA. xw...(a)mail.med.cornell.edu Two hundred years after the discovery of the pharmaceutical usefulness of aspirin, it and aspirin-like drugs, a family with an ever-increasing number of members, are an indispensable part of modern life. However, the question as to how these drugs work in the body has remained unsettled. It is postulated here that this group of drugs may exert their therapeutic (and adverse) effects by chelating various physiologically important metallic cations in the body. The chelate theory is supported by the vast majority, if not all, of the observations on these drugs made in the past. Publication Types: * Review * Review, academic PMID: 9578329, UI: 98237440 _________________________________________________________________ http://news.excite.com/news/r/010928/18/health-iron Iron Imbalance in Brain May Cause Migraine Updated: Fri, Sep 28 6:22 PM EDT By Will Boggs, MD NEW YORK (Reuters Health) - Abnormalities in the way the brain's pain control center handles iron may lead to the development of migraine attacks and headaches, according to a study by Kansas researchers. During migraine, a portion of the brain known as the periaqueductal gray matter (PAG) may fail to "switch on" to prevent pain, Dr. K. Michael Welch of the University of Kansas Medical Center in Kansas City told Reuters Health. "In migraine, a trigger such as stress activates the PAG but it does not switch on because it is dysfunctional," he explained, "or else switches on an abnormal part." The result? "Pain instead of no pain," according to Welch. His team studied levels of iron in the PAG of patients with either migraine headaches or recurrent, non-migraine headaches and compared them to levels in people without headache or migraine. Changes in iron levels can reflect changes in the way the cells of the PAG work, the authors pointed out. According to the report, published in a recent issue of the journal Headache, iron levels in the PAG were significantly increased in patients with migraine and those with headache compared to the headache-free group. In fact, the researchers pointed out, the longer patients had experienced headaches, the higher the iron levels in the PAG were, though iron levels at the beginning of their illness were still clearly higher than normal. Increased iron levels may be both a cause of migraine attacks and a result of repeated headaches, the investigators noted. "Thus, we believe that the increased (iron levels) in our migraine groups reflect impaired iron (balance), possibly associated with (nerve) dysfunction or damage," the authors concluded. "Perhaps the PAG abnormality is essential to the cause of the headache in migraine," Welch said. "The gradual deposition of iron increases dysfunction, and headaches coalesce from episodic to continuous." How, then, might one minimize the damage from increased iron stores? Welch advised, "Treat episodes quickly and prevent (attacks) whenever possible." SOURCE: Headache 2001;41:629-637. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
|
Pages: 1 Prev: Ironrestriction and Multidrug Resistance Next: Arthritis Wonder Drugs |