Iron In Type 2 Diabetes
in [Kidney Diseases]
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From: ironjustice on 12 Jun 2008 14:42 The role of iron in type 2 diabetes in humans. Rajpathak SN, Crandall J, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB Biochim Biophys Acta 2008 May 3. The role of micronutrients in the etiology of type 2 diabetes is not well studied. Several lines of evidence suggest that iron may a role in the pathogenesis of type 2 diabetes. Iron is a strong pro-oxidant and high body iron levels are associated with increased level of oxidative stress that may elevate the risk of type 2 diabetes. Several epidemiological studies have reported a positive association between high body iron levels, as measured by circulating ferritin level, and the risk of type 2 diabetes and of other insulin resistance states such as the metabolic syndrome, gestational diabetes and polycystic ovarian syndrome. In addition, increased dietary intake of iron, especially that of heme iron, is associated with risk of type 2 diabetes in apparently healthy populations. Results from studies that evaluated the association between genetic mutations related to iron metabolism have been inconsistent. Further, several clinical trials suggest that by phlebotomy induced reduction in body iron levels may improve insulin sensitivity in humans. However, no interventional studies have yet directly evaluated the effect of reducing iron intake or body iron levels on the risk of developing type 2 diabetes. Such studies are required to prove the causal relationship between moderate iron overload and diabetes risk. Biochimica et biophysica acta [Biochim Biophys Acta] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
From: ironjustice on 12 Jun 2008 20:22 On Jun 12, 2:15 pm, "Paul T. Holland" <pholl...(a)bellatlantic.net> wrote: long winded whack << The role of iron in type 2 diabetes in humans. Rajpathak SN, Crandall J, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB Biochim Biophys Acta 2008 May 3. The role of micronutrients in the etiology of type 2 diabetes is not well studied. Several lines of evidence suggest that iron may a role in the pathogenesis of type 2 diabetes. Iron is a strong pro-oxidant and high body iron levels are associated with increased level of oxidative stress that may elevate the risk of type 2 diabetes. Several epidemiological studies have reported a positive association between high body iron levels, as measured by circulating ferritin level, and the risk of type 2 diabetes and of other insulin resistance states such as the metabolic syndrome, gestational diabetes and polycystic ovarian syndrome. In addition, increased dietary intake of iron, especially that of heme iron, is associated with risk of type 2 diabetes in apparently healthy populations. Results from studies that evaluated the association between genetic mutations related to iron metabolism have been inconsistent. Further, several clinical trials suggest that by phlebotomy induced reduction in body iron levels may improve insulin sensitivity in humans. However, no interventional studies have yet directly evaluated the effect of reducing iron intake or body iron levels on the risk of developing type 2 diabetes. Such studies are required to prove the causal relationship between moderate iron overload and diabetes risk. Biochimica et biophysica acta [Biochim Biophys Acta] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
From: Paul T. Holland on 13 Jun 2008 17:55 so, you can't actually rebute anything? [that is of course a rhetorical question] you see tom - that's what discussion, even one that is heated and a dispute, is all about you 'could' be better than that - ironjustice wrote: > > On Jun 12, 2:15 pm, "Paul T. Holland" <pholl...(a)bellatlantic.net> > wrote: long winded whack << > > The role of iron in type 2 diabetes in humans. > Rajpathak SN, Crandall J, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB > Biochim Biophys Acta 2008 May 3. > > The role of micronutrients in the etiology of type 2 diabetes is not > well studied. > Several lines of evidence suggest that iron may a role in the > pathogenesis of type 2 diabetes. > Iron is a strong pro-oxidant and high body iron levels are associated > with increased level of oxidative stress that may elevate the risk of > type 2 diabetes. > Several epidemiological studies have reported a positive association > between high body iron levels, as measured by circulating ferritin > level, and the risk of type 2 diabetes and of other insulin > resistance > states such as the metabolic syndrome, gestational diabetes and > polycystic ovarian syndrome. > In addition, increased dietary intake of iron, especially that of > heme > iron, is associated with risk of type 2 diabetes in apparently > healthy > populations. > Results from studies that evaluated the association between genetic > mutations related to iron metabolism have been inconsistent. > Further, several clinical trials suggest that by phlebotomy induced > reduction in body iron levels may improve insulin sensitivity in > humans. > However, no interventional studies have yet directly evaluated the > effect of reducing iron intake or body iron levels on the risk of > developing type 2 diabetes. > Such studies are required to prove the causal relationship between > moderate iron overload and diabetes risk. > Biochimica et biophysica acta [Biochim Biophys Acta] > ---------------------------------------------------------------------------��----- > > Who loves ya. > Tom > > Jesus Was A Vegetarian! > http://tinyurl.com/2r2nkh > > Man Is A Herbivore! > http://tinyurl.com/a3cc3 > > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk
From: ironjustice on 13 Jun 2008 19:34 On Jun 13, 2:55 pm, "Paul T. Holland" <pholl...(a)bellatlantic.net> wrote: long winded whack << The role of iron in type 2 diabetes in humans. Rajpathak SN, Crandall J, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB Biochim Biophys Acta 2008 May 3. The role of micronutrients in the etiology of type 2 diabetes is not well studied. Several lines of evidence suggest that iron may a role in the pathogenesis of type 2 diabetes. Iron is a strong pro-oxidant and high body iron levels are associated with increased level of oxidative stress that may elevate the risk of type 2 diabetes. Several epidemiological studies have reported a positive association between high body iron levels, as measured by circulating ferritin level, and the risk of type 2 diabetes and of other insulin resistance states such as the metabolic syndrome, gestational diabetes and polycystic ovarian syndrome. In addition, increased dietary intake of iron, especially that of heme iron, is associated with risk of type 2 diabetes in apparently healthy populations. Results from studies that evaluated the association between genetic mutations related to iron metabolism have been inconsistent. Further, several clinical trials suggest that by phlebotomy induced reduction in body iron levels may improve insulin sensitivity in humans. However, no interventional studies have yet directly evaluated the effect of reducing iron intake or body iron levels on the risk of developing type 2 diabetes. Such studies are required to prove the causal relationship between moderate iron overload and diabetes risk. Biochimica et biophysica acta [Biochim Biophys Acta] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > so, you can't actually rebute anything? [that is of course a rhetorical > question] > > you see tom - that's what discussion, even one that is heated and a > dispute, is all about > > you 'could' be better than that - > > > > ironjustice wrote: > > > On Jun 12, 2:15 pm, "Paul T. Holland" <pholl...(a)bellatlantic.net> > > wrote: long winded whack << > > > The role of iron in type 2 diabetes in humans. > > Rajpathak SN, Crandall J, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB > > Biochim Biophys Acta 2008 May 3. > > > The role of micronutrients in the etiology of type 2 diabetes is not > > well studied. > > Several lines of evidence suggest that iron may a role in the > > pathogenesis of type 2 diabetes. > > Iron is a strong pro-oxidant and high body iron levels are associated > > with increased level of oxidative stress that may elevate the risk of > > type 2 diabetes. > > Several epidemiological studies have reported a positive association > > between high body iron levels, as measured by circulating ferritin > > level, and the risk of type 2 diabetes and of other insulin > > resistance > > states such as the metabolic syndrome, gestational diabetes and > > polycystic ovarian syndrome. > > In addition, increased dietary intake of iron, especially that of > > heme > > iron, is associated with risk of type 2 diabetes in apparently > > healthy > > populations. > > Results from studies that evaluated the association between genetic > > mutations related to iron metabolism have been inconsistent. > > Further, several clinical trials suggest that by phlebotomy induced > > reduction in body iron levels may improve insulin sensitivity in > > humans. > > However, no interventional studies have yet directly evaluated the > > effect of reducing iron intake or body iron levels on the risk of > > developing type 2 diabetes. > > Such studies are required to prove the causal relationship between > > moderate iron overload and diabetes risk. > > Biochimica et biophysica acta [Biochim Biophys Acta] > > -------------------------------------------------------------------------------- > > > Who loves ya. > > Tom > > > Jesus Was A Vegetarian! > >http://tinyurl.com/2r2nkh > > > Man Is A Herbivore! > >http://tinyurl.com/a3cc3 > > > DEAD PEOPLE WALKING > >http://tinyurl.com/zk9fk- Hide quoted text - > > - Show quoted text -
From: ironjustice on 13 Jun 2008 19:35
On Jun 13, 2:56 pm, "Paul T. Holland" <pholl...(a)bellatlantic.net> wrote:long winded whack << The role of iron in type 2 diabetes in humans. Rajpathak SN, Crandall J, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB Biochim Biophys Acta 2008 May 3. The role of micronutrients in the etiology of type 2 diabetes is not well studied. Several lines of evidence suggest that iron may a role in the pathogenesis of type 2 diabetes. Iron is a strong pro-oxidant and high body iron levels are associated with increased level of oxidative stress that may elevate the risk of type 2 diabetes. Several epidemiological studies have reported a positive association between high body iron levels, as measured by circulating ferritin level, and the risk of type 2 diabetes and of other insulin resistance states such as the metabolic syndrome, gestational diabetes and polycystic ovarian syndrome. In addition, increased dietary intake of iron, especially that of heme iron, is associated with risk of type 2 diabetes in apparently healthy populations. Results from studies that evaluated the association between genetic mutations related to iron metabolism have been inconsistent. Further, several clinical trials suggest that by phlebotomy induced reduction in body iron levels may improve insulin sensitivity in humans. However, no interventional studies have yet directly evaluated the effect of reducing iron intake or body iron levels on the risk of developing type 2 diabetes. Such studies are required to prove the causal relationship between moderate iron overload and diabetes risk. Biochimica et biophysica acta [Biochim Biophys Acta] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |