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From: Paul T. Holland on 13 Jun 2008 21:00
thanks tom

every time you post it, it proves you wrong...by your own hand


odd as it would appear, that must be what you want

ironjustice wrote:
>
> On Jun 13, 3:06 pm, "Paul T. Holland" <pholl...(a)bellatlantic.net>
> wrote:long winded whack <<
>
> Br J Haematol. 2006 Aug;134(4):438-44. Epub 2006 Jul 4.Related
> Articles, Links
> Comment in:
> Br J Haematol. 2006 Oct;135(2):271-2.
>
> Effect of enhanced iron chelation therapy on glucose metabolism in
> patients with beta-thalassaemia major.
>
> Farmaki K, Angelopoulos N, Anagnostopoulos G, Gotsis E, Rombopoulos
> G,
> Tolis G.
>
> Haematological Department, Korinthos General Hospital, Korinthos,
> Greece.
>
> Recently introduced chelation regimens that combine deferoxamine
> (DFO)
> and deferiprone have been shown to have greater efficacy in promoting
> iron excretion than either chelator alone and have been associated
> with rapid reduction of the iron load in the heart and liver, and
> with
> reversal of cardiac dysfunction. It is unclear whether this combined
> therapy could be associated with a reduction in iron load or decline
> in the severity of iron-induced endocrinopathies. Starting in January
> 2001, 42 patients with beta-thalassaemia major, previously maintained
> on subcutaneous DFO only, were switched to combined treatment with
> DFO
> and deferiprone. The primary endpoint was to investigate the effects
> of this therapy on the glucose metabolism characteristics of this
> population. Combination therapy markedly decreased ferritin levels
> (638 +/- 1345 vs. 2991 +/- 2093 microg/l, P < 0.001). Glucose
> responses were improved at all times during an oral glucose tolerance
> test, particularly in patients in early stages of glucose
> intolerance.
> Glucose quantitative secretion also decreased significantly with
> combined therapy, while no significant change occurred in insulin
> levels in any group. Insulin secretion, according to the homeostasis
> assessment model, markedly increased in all groups, while overall
> reduction in insulin sensitivity did not reach statistical
> significance. This study showed that the combination of DFO and
> deferiprone was associated with an improvement in liver iron
> deposition and glucose intolerance.
>
> PMID: 16822284 [PubMed - indexed for MEDLINE]
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!
> http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!
> http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk
From: ironjustice on 13 Jun 2008 21:34
On Jun 13, 6:00 pm, "Paul T. Holland" <pholl...(a)bellatlantic.net>
wrote:long winded whack <<

You can't seem to get the .. drift .. man ..

YOU ARE A FKG WHACKJOB .. !!
YOU ARE A FKG WHACKJOB .. !!
YOU ARE A FKG WHACKJOB .. !!
YOU ARE A FKG WHACKJOB .. !!
YOU ARE A FKG WHACKJOB .. !!
YOU ARE A FKG WHACKJOB .. !!

Stay off my threads ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk


> thanks  tom
>
> every time you post it, it proves you wrong...by your own hand
>
> odd as it would appear, that must be what you want
>
>
>
> ironjustice wrote:
>
> > On Jun 13, 3:06 pm, "Paul T. Holland" <pholl...(a)bellatlantic.net>
> > wrote:long winded whack <<
>
> > Br J Haematol. 2006 Aug;134(4):438-44. Epub 2006 Jul 4.Related
> > Articles, Links
> > Comment in:
> > Br J Haematol. 2006 Oct;135(2):271-2.
>
> > Effect of enhanced iron chelation therapy on glucose metabolism in
> > patients with beta-thalassaemia major.
>
> > Farmaki K, Angelopoulos N, Anagnostopoulos G, Gotsis E, Rombopoulos
> > G,
> > Tolis G.
>
> > Haematological Department, Korinthos General Hospital, Korinthos,
> > Greece.
>
> > Recently introduced chelation regimens that combine deferoxamine
> > (DFO)
> > and deferiprone have been shown to have greater efficacy in promoting
> > iron excretion than either chelator alone and have been associated
> > with rapid reduction of the iron load in the heart and liver, and
> > with
> > reversal of cardiac dysfunction. It is unclear whether this combined
> > therapy could be associated with a reduction in iron load or decline
> > in the severity of iron-induced endocrinopathies. Starting in January
> > 2001, 42 patients with beta-thalassaemia major, previously maintained
> > on subcutaneous DFO only, were switched to combined treatment with
> > DFO
> > and deferiprone. The primary endpoint was to investigate the effects
> > of this therapy on the glucose metabolism characteristics of this
> > population. Combination therapy markedly decreased ferritin levels
> > (638 +/- 1345 vs. 2991 +/- 2093 microg/l, P < 0.001). Glucose
> > responses were improved at all times during an oral glucose tolerance
> > test, particularly in patients in early stages of glucose
> > intolerance.
> > Glucose quantitative secretion also decreased significantly with
> > combined therapy, while no significant change occurred in insulin
> > levels in any group. Insulin secretion, according to the homeostasis
> > assessment model, markedly increased in all groups, while overall
> > reduction in insulin sensitivity did not reach statistical
> > significance. This study showed that the combination of DFO and
> > deferiprone was associated with an improvement in liver iron
> > deposition and glucose intolerance.
>
> > PMID: 16822284 [PubMed - indexed for MEDLINE]
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!
> >http://tinyurl.com/2r2nkh
>
> > Man Is A Herbivore!
> >http://tinyurl.com/a3cc3
>
> > DEAD PEOPLE WALKING
> >http://tinyurl.com/zk9fk- Hide quoted text -
>
> - Show quoted text -

From: ironjustice on 13 Jun 2008 22:01
On Jun 12, 8:55 pm, ironjustice <teamtan...(a)hotmail.com> wrote: Effect
of enhanced iron chelation therapy <<

"Correlation of serum ferritin concentrations with 2-hour glucose
concentration (top) in 538 nondiabetic persons and insulin
sensitivity
in 257 nondiabetic persons."


http://www.annals.org/cgi/content/full/139/10/869-b?ct


"Bloodletting improved glycemia and insulin sensitivity in patients
with
type 2 diabetes "

from the Annals of Internal Medicine
11/18/03


Association of High Serum Ferritin Concentration with Glucose
Intolerance and
Insulin Resistance in Healthy People


Background:
Increasing evidence points to an association between increased
body iron storage and type 2 diabetes mellitus, even outside the
context of
hemochromatosis (1, 2).
A small intervention study provided preliminary evidence that
bloodletting, which resulted in 50% reduction of serum ferritin
concentrations, improved glycemia and insulin sensitivity in patients
with type 2 diabetes (3).
However, interpretation of mechanistic studies in patients with overt
type 2 diabetes mellitus are complicated because glycemic control
itself influences serum ferritin concentrations (glycosylated ferritin
has a longer serum half-life) and primary effects on insulin
sensitivity or ß-cell function can no longer be studied.
Objective:
To analyze the relationship between iron variables and glucose
tolerance, insulin sensitivity, and ß-cell function in nondiabetic
persons.

Conclusion:
It may become advisable to routinely screen for mildly elevated or
even high-normal serum ferritin concentrations in the context of
glucose
intolerance.
If prospective and interventional studies confirm an etiologic
role of iron overload in the pathogenesis of insulin resistance and
type 2
diabetes, reduced dietary iron intake, especially in men and
postmenopausal
women (9) with additional risk factors for type 2 diabetes, would
appear to be
a logical consequence.
In the future, actively lowering body iron stores may become a tool in
preventing type 2 diabetes in selected subgroups.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk




> Br J Haematol. 2006 Aug;134(4):438-44. Epub 2006 Jul 4.Related
> Articles, Links
> Comment in:
> Br J Haematol. 2006 Oct;135(2):271-2.
>
> Effect of enhanced iron chelation therapy on glucose metabolism in
> patients with beta-thalassaemia major.
>
> Farmaki K, Angelopoulos N, Anagnostopoulos G, Gotsis E, Rombopoulos G,
> Tolis G.
>
> Haematological Department, Korinthos General Hospital, Korinthos,
> Greece.
>
> Recently introduced chelation regimens that combine deferoxamine (DFO)
> and deferiprone have been shown to have greater efficacy in promoting
> iron excretion than either chelator alone and have been associated
> with rapid reduction of the iron load in the heart and liver, and with
> reversal of cardiac dysfunction. It is unclear whether this combined
> therapy could be associated with a reduction in iron load or decline
> in the severity of iron-induced endocrinopathies. Starting in January
> 2001, 42 patients with beta-thalassaemia major, previously maintained
> on subcutaneous DFO only, were switched to combined treatment with DFO
> and deferiprone. The primary endpoint was to investigate the effects
> of this therapy on the glucose metabolism characteristics of this
> population. Combination therapy markedly decreased ferritin levels
> (638 +/- 1345 vs. 2991 +/- 2093 microg/l, P < 0.001). Glucose
> responses were improved at all times during an oral glucose tolerance
> test, particularly in patients in early stages of glucose intolerance.
> Glucose quantitative secretion also decreased significantly with
> combined therapy, while no significant change occurred in insulin
> levels in any group. Insulin secretion, according to the homeostasis
> assessment model, markedly increased in all groups, while overall
> reduction in insulin sensitivity did not reach statistical
> significance. This study showed that the combination of DFO and
> deferiprone was associated with an improvement in liver iron
> deposition and glucose intolerance.
>
> PMID: 16822284 [PubMed - indexed for MEDLINE]
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

From: J666 on 13 Jun 2008 22:15
On Fri, 13 Jun 2008 20:34:11 -0500, ironjustice wrote
(in article
<93bc6985-7e40-4cb6-a65a-93b20826504a(a)26g2000hsk.googlegroups.com>):

> On Jun 13, 6:00�pm, "Paul T. Holland" <pholl...(a)bellatlantic.net>
> wrote:long winded whack <<
>
> You can't seem to get the .. drift .. man ..
>
> YOU ARE A FKG WHACKJOB .. !!
> YOU ARE A FKG WHACKJOB .. !!
> YOU ARE A FKG WHACKJOB .. !!
> YOU ARE A FKG WHACKJOB .. !!
> YOU ARE A FKG WHACKJOB .. !!
> YOU ARE A FKG WHACKJOB .. !!
>
> Stay off my threads ..
>
>
> Who loves ya.
> Tom


Your true color (rust) finally comes out.

From: Paul T. Holland on 15 Jun 2008 16:44
tommy asks for even more whack - so he must be given that which he
demands:

ironjustice wrote:
>
> On Jun 13, 6:00 pm, "Paul T. Holland" <pholl...(a)bellatlantic.net>
> wrote:long winded whack <<

but i did thank you didn't i? lol

>
> You can't seem to get the .. drift .. man ..

that the study you posted clearly determines the genetic cause of the
medical condition? but indeed we all did tommy - exactly as you posted
it

more and more you do these things, and more and more it shows that your
primary thesis is wrong - ]

so, since it is 'you' who continues to post these thngs, we can only
conclude that

you really - really - really - want us to know that you have be
incorrect all these years!!!


>
> YOU ARE A FKG WHACKJOB .. !!

whackado whackado


> YOU ARE A FKG WHACKJOB .. !!

dowhackadowhacka


> YOU ARE A FKG WHACKJOB .. !!

whackawhackawhacka


> YOU ARE A FKG WHACKJOB .. !!

whackadowhackadowhackado


> YOU ARE A FKG WHACKJOB .. !!

do, do, do whacka


> YOU ARE A FKG WHACKJOB .. !!

dooooooowhaaaaaaaaawhacka


>
> Stay off my threads ..


don't you mean blue suede shoes?

>
> Who loves ya.

do you tommy - really? truly? no fooling? promise? you're shining us on
are you? cross your heart?

> Tom
>
> Jesus Was A Vegetarian!
> http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!
> http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk
>
> > thanks tom
> >
> > every time you post it, it proves you wrong...by your own hand
> >
> > odd as it would appear, that must be what you want
> >
> >
> >
> > ironjustice wrote:
> >
> > > On Jun 13, 3:06 pm, "Paul T. Holland" <pholl...(a)bellatlantic.net>
> > > wrote:long winded whack <<
> >
> > > Br J Haematol. 2006 Aug;134(4):438-44. Epub 2006 Jul 4.Related
> > > Articles, Links
> > > Comment in:
> > > Br J Haematol. 2006 Oct;135(2):271-2.
> >
> > > Effect of enhanced iron chelation therapy on glucose metabolism in
> > > patients with beta-thalassaemia major.
> >
> > > Farmaki K, Angelopoulos N, Anagnostopoulos G, Gotsis E, Rombopoulos
> > > G,
> > > Tolis G.
> >
> > > Haematological Department, Korinthos General Hospital, Korinthos,
> > > Greece.
> >
> > > Recently introduced chelation regimens that combine deferoxamine
> > > (DFO)
> > > and deferiprone have been shown to have greater efficacy in promoting
> > > iron excretion than either chelator alone and have been associated
> > > with rapid reduction of the iron load in the heart and liver, and
> > > with
> > > reversal of cardiac dysfunction. It is unclear whether this combined
> > > therapy could be associated with a reduction in iron load or decline
> > > in the severity of iron-induced endocrinopathies. Starting in January
> > > 2001, 42 patients with beta-thalassaemia major, previously maintained
> > > on subcutaneous DFO only, were switched to combined treatment with
> > > DFO
> > > and deferiprone. The primary endpoint was to investigate the effects
> > > of this therapy on the glucose metabolism characteristics of this
> > > population. Combination therapy markedly decreased ferritin levels
> > > (638 +/- 1345 vs. 2991 +/- 2093 microg/l, P < 0.001). Glucose
> > > responses were improved at all times during an oral glucose tolerance
> > > test, particularly in patients in early stages of glucose
> > > intolerance.
> > > Glucose quantitative secretion also decreased significantly with
> > > combined therapy, while no significant change occurred in insulin
> > > levels in any group. Insulin secretion, according to the homeostasis
> > > assessment model, markedly increased in all groups, while overall
> > > reduction in insulin sensitivity did not reach statistical
> > > significance. This study showed that the combination of DFO and
> > > deferiprone was associated with an improvement in liver iron
> > > deposition and glucose intolerance.
> >
> > > PMID: 16822284 [PubMed - indexed for MEDLINE]
> >
> > > Who loves ya.
> > > Tom
> >
> > > Jesus Was A Vegetarian!
> > >http://tinyurl.com/2r2nkh
> >
> > > Man Is A Herbivore!
> > >http://tinyurl.com/a3cc3
> >
> > > DEAD PEOPLE WALKING
> > >http://tinyurl.com/zk9fk- Hide quoted text -
> >
> > - Show quoted text -
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