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Increasing infections... Archives of Internal Medicine 2010;170(4):347-353 "Clinical and Economic Outcomes Attributable to Health Care-Associated Sepsis and Pneumonia" It is my hypothesis that the "secular trend," the increase in size and earlier puberty occurring in children, is caused by an increase in the percentage of individuals ... 27 Feb 2010 18:50
Schizophrenia vs. Celiac: different sets of antibodies to wheat? A link between Celiac and schizophrenia has been postulated before. Some schizophrenics have even been cured with a gluten-free diet. Now we have evidence that Celiac and some forms of schizophrenia may both be driven by antibodies to different antigen targets in wheat. Given that wheat, rice, red meat and c... 20 Feb 2010 12:27
Antibodies, sympathetic drive and the development of Type I diabetes I think the lack of specific antibodies against infectious diseases may indicate a failure of sympathetic-mediated immune responses. In M.S., it looks like a history of sympathetic overdrive is protective - a previous TB infection, for example. This study pointing to the lack of antibodies with Type I diabete... 20 Feb 2010 03:42
Infectious diseases induce anti-TG antibodies, similar to Celiac Further fleshing out this line of thought... Clin Exp Immunol. 2010 Feb;159(2):217-23. Epub 2009 Nov 12. � Anti-transglutaminase antibodies in non-coeliac children suffering from infectious diseases. Ferrara F, Quaglia S, Caputo I, Esposito C, Lepretti M, Pastore S, Giorgi R, Martelossi S, Dal Molin G, Di To... 20 Feb 2010 04:49
Could Celiac anti-TG autoantibodies cause Crohn's-like colitis by impairing macrophages? If you've followed my posts in alt.support.crohns-colitis, you know there is plenty of evidence piling up that Crohn's is due to defective innate immunity. Innate pathways that synthesize antimicrobials like cathelicidin are defective via impaired butyrate uptake or low levels of Vitamin D3 - sometimes even hi... 20 Feb 2010 01:30
PPARalpha stimulation limits lymphocyte proliferation As I pointed out several years ago, the mu opioid/cannabinoid complex is under epigenetic control (via OCTN2/butyrate/carnitine uptake) and there was evidence even back then that cannabinoid signals limited lymphocyte proliferation. Now we have more direct evidence of this via PPARalpha, a regulator of OCTN2. ... 18 Feb 2010 07:15
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Folic acid receptor antibodies, vitamin D3 and milk consumption in autoimmune disease For Kofi: Some articles on folic acid metabolism, its relation to cancer, and some related patents: http://www.freepatentsonline.com/5416016.html http://www.freepatentsonline.com/5108921.html http://www.faqs.org/patents/app/20090081710 http://www.faqs.org/patents/app/20080317706 http://www.patentsto... 8 Feb 2010 22:36
Restorative yoga You know when you feel exhausted all the time and keep on having low grade infections or chronic pain that no amount of therapy will shift? http://www.restorative-yoga.net/ ... 4 Feb 2010 11:12
Bikram Yoga It can be done at home very easily once you have learnt the sequence that is right for you and it is also a wonderful personal support to give yourself a regular Restorative Yoga class if you feel you are burning out, stressing out or going through a very stressful period of your life. http://www.restorative-yoga.... 4 Feb 2010 07:48
The role of SIRT6, glucose metabolism, lifespan and inflammation Nicotinamide phosphoribosyltransferase (Nampt) inhibitors such as FK866 are potent inhibitors of NAD+ synthesis that show promise for the treatment of different forms of cancer. Based on Nampt upregulation in activated T lymphocytes and on preliminary reports of lymphopenia in FK866 treated patients, we have in... 25 Jan 2010 21:53
Fasting (via FOXO) upregulates innate antimicrobials like cathelicidin Fasting upregulates innate antimicrobials? Well, you heard it from me first. I stated quite a while back that fasting upregulates OCTN2 and this should, in turn, upregulate carnitine uptake, butyrate uptake and histone acetylation leading to enhanced expression of those genes under HDAC control - including de... 24 Jan 2010 03:35
The TLR2/macrophage/sympathetic response inhibits autoimmunity/promotes self-tolerance This provides the final pieces of evidence in a relationship I've suspected for a few years now. The macrophage/TLR2/TLR4/sympathetic nervous system suppresses autoimmunity directly through means like IL-10 secretion. Dysfunction in this system - whether via defects in the TLR2/macrophage signal cascade or vi... 22 Jan 2010 23:04
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PAID Research Opp for Individuals w/ Platelet Disorders in SF Bay Area, CA Interface Analysis is seeking individuals diagnosed with Idiopathic (or Immune) thrombocytopenic purpura - ITP (Platelet Disorder or Evan Syndrome Disorder) to participate in an important non-invasive consumer study to be conducted at our Cupertino/San Jose research facility in April. Sessions will take approximate... 15 Jan 2010 13:53
bleeding hemorrhoids not dangerous? I was reading that people seem to think that bleeding hemorrhoids are not dangerous. However, the bleeding is happening in a spot where there are alot more bacteria than other parts of the body. Also, it seems that the membranes of the intestines are almost as permeable as the nose which is why suppositories ar... 10 Jan 2010 06:25
strong stuff: http://www.pharmamafia.com http://www.pharmamafia.com Enjoy! .. -- Die volle H�rte: http://www.kindersprechstunde.at *************************************************************** Die Medienmafia � Die Regividerm-Verschw�rung http://www.transgallaxys.com/~kanzlerzwo/showtopic.php?threadid=5710 ... 3 Jan 2010 23:47
HDAC1 upregulation in neurodegneration impairs neuronal mitochondrial transport This points to a defective OCTN2/carnitine/butyrate uptake mechanism which perhaps accounts for the gender bias in multiple sclerosis. Testosterone is a carnitine transporter and given how the movement of mitochondria is vital in neurotransmission, this might help link testosterone and NGF signaling. In any c... 3 Jan 2010 07:17 |