Aryl hydrocarbon receptor suppresses TNF-alpha production in macrophages
J Exp Med. 2009 Aug 31;206(9):2027-35. Epub 2009 Aug 24. Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses. Kimura A, Naka T, Nakahama T, Chinen I, Masuda K, Nohara K, Fujii-Kuriyama Y, Kishimoto T. Laboratory of Immune Regulation, Osaka University Graduate School... 22 Nov 2009 07:12
Enhanced Insulin & Insulin Resistance?
Hello, In view of following terms, can increase in insulin's exposure to target cells by irregular food habits, by oral hypoglycemic medicines and/or by exogenous insulin cause down-regulation of insulin receptors resulting insulin resistance? Please give special attention to long & very long acting insulins. ... 23 Nov 2009 03:05
IDO activates Tregs, blocks Th17 cells; should the autoimmune eat turkey/take tryptophan?
Tryptophan inhibits IDO and turkey is rich in IDO. This indicates that consuming a lot of tryptophan would stoke Th17 cells and an autoimmune process. It also hints at why intermittent fasting might be helpful - it's increasing the amino acid starvation response. Given the role tryptophan plays in serotonin ... 30 Oct 2009 07:51
Astrocyte carnitine transporter OCTN3 also responds to PPARalpha
Int J Biochem Cell Biol. 2009 Sep 6; � Organic cation/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist. Januszewicz E, Pajak B, Gajkowska B, Samluk L, Djavadian RL, Hinton BT, Nalecz KA. Nencki Institute of Experimental Biology, Poli... 25 Oct 2009 03:25
Mouse OCTN2 is regulated by a PPAR response element
Biochem Pharmacol. 2009 Oct 9; � Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha) via a PPRE located in the first intron. Wen G, Ringseis R, Eder K. Institute of Agricultural and Nutritional Sciences, Martin-Luther-Universitat Halle-Wittenberg, Von-Danckelmann-... 25 Oct 2009 03:25
TNF-alpha induces vitamin D3 resistance
This implies anti-TNF-alpha therapy in Crohn's might help boost cathelicidin and other vitamin D3-mediated responses. Does anybody have more recent papers on inflammation-induced vitamin D3 resistance? J Cell Biochem. 2004 Jul 1;92(4):833-48 � Integration of the NfkappaB p65 subunit into the vitamin D recep... 23 Oct 2009 07:48
The antiviral roles of FoxP3, Tregs and CREB
CREB is disturbed in schizophrenia (via DISC1). Cathelicidin also requires CREB. This hints, to me at any rate, of a connection among viral infections, dopamine production and autoimmunity in schizophrenia - and perhaps more generally. What's also interesting are the PDE4 inhibitors given both in dopamine-de... 22 Oct 2009 11:55
Activation of Vit. D3 by miR-125b, which is downregulated in cancer
Mol Pharmacol. 2009 Oct;76(4):702-9. Epub 2009 Jul 1. � Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125b. Komagata S, Nakajima M, Takagi S, Mohri T, Taniya T, Yokoi T. Drug Metabolism and Toxicology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japa... 19 Oct 2009 05:22
Immune, sympathetic and pain/fatigue signaling in chronic fatigue patients before & after exercise
As you will recall, in the past I've posted information linking ASIC3 with chronic fatigue/FMS suggesting that p75NTR promoters like acetyl-l-carnitine might alleviate some of the pain and account for the reason men are less likely to get chronic fatigue. This paper is the first as far as I know to confirm ASI... 14 Oct 2009 01:39
NQO1/NQO2, vitamin K and vitamin D3 - what's the connection?
In article <2c3c742d-05a0-464b-9765-be4a26537183(a)v36g2000yqv.googlegroups.com>, jay <jaym1212(a)hotmail.com> wrote: Most people could benefit from increasing Phase 2 inducers. But if one has a NQO1 variant (possibly my case), then it might be best to limit foods that produce reactive quinones. For exam... 11 Oct 2009 07:11