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The Patient Experience Hi Everyone Just top let you know that we are launching a new web site called The Patient Experience http://www.patient-experience.com/ We thought we would give members of the group the opportunity to have a look at the site before it goes fully live. It would be great if you could give us any feedback. W... 9 Mar 2010 06:45
Epinephrine prevents dopaminergic dysfunction from C-section This is a fascinating little paper on which I just stumbled. It appears events at birth can permanently alter functioning of the dopamine subsystems in the brain. I certainly think this is relevant to problems like ADHD. My intuition tells me this might mimic vitamin D problems or it might directly overlap w... 3 Mar 2010 20:55
Cathelicidin peaks in newborns delivered via childbirth but not C-section This may explain a link between C-sections and autism, schizophrenia and other infection-related chronic conditions. C-sections also reduce a burst of oxytocin which protects newborn neurons from hypoxia. This is really sharp work. Acta Paediatr. 2010 Feb 22 � Maternal plasma level of antimicrobial peptide... 4 Mar 2010 00:12
Butyrate increases the % of choline acetyltransferase enteric neurons Choline acetyltransferase (ChAT) is the enzyme responsible for making acetylcholine. This could be an indication that butyrate boosts parasympathetic function in the gut to help balance out sympathetic function. See my prior discussion in sci.life-extension on choline and parasympathetics. Gastroenterology... 1 Mar 2010 02:38
Lack of Scientific proof for some homeopathy On Jan 22, 2:35 pm, JD <J...(a)NoDen.con> wrote: As I understand it, the medicine is diluted out to the point where there is nothing left. This explains why these medicines do absolutely nothing. Rather simple minded and WRONG. Try going to Brian Josephson's home page, and read his comments on "I... 4 Mar 2010 18:06
Schizophrenia vs. Celiac: different sets of antibodies to wheat? A link between Celiac and schizophrenia has been postulated before. Some schizophrenics have even been cured with a gluten-free diet. Now we have evidence that Celiac and some forms of schizophrenia may both be driven by antibodies to different antigen targets in wheat. Given that wheat, rice, red meat and c... 21 Feb 2010 04:56
Antibodies, sympathetic drive and the development of Type I diabetes I think the lack of specific antibodies against infectious diseases may indicate a failure of sympathetic-mediated immune responses. In M.S., it looks like a history of sympathetic overdrive is protective - a previous TB infection, for example. This study pointing to the lack of antibodies with Type I diabete... 20 Feb 2010 03:42
T. gondii antibodies and the pathogenesis of IBD Ann N Y Acad Sci. 2009 Sep;1173:640-8. Infectious serologies and autoantibodies in inflammatory bowel disease: insinuations at a true pathogenic role. Lidar M, Langevitz P, Barzilai O, Ram M, Porat-Katz BS, Bizzaro N, Tonutti E, Maieron R, Chowers Y, Bar-Meir S, Shoenfeld Y. Center for Autoimmune Disease, Rheu... 20 Feb 2010 03:42
Infectious diseases induce anti-TG antibodies, similar to Celiac Further fleshing out this line of thought... Clin Exp Immunol. 2010 Feb;159(2):217-23. Epub 2009 Nov 12. � Anti-transglutaminase antibodies in non-coeliac children suffering from infectious diseases. Ferrara F, Quaglia S, Caputo I, Esposito C, Lepretti M, Pastore S, Giorgi R, Martelossi S, Dal Molin G, Di To... 20 Feb 2010 04:48
Could Celiac anti-TG autoantibodies cause Crohn's-like colitis by impairing macrophages? If you've followed my posts in alt.support.crohns-colitis, you know there is plenty of evidence piling up that Crohn's is due to defective innate immunity. Innate pathways that synthesize antimicrobials like cathelicidin are defective via impaired butyrate uptake or low levels of Vitamin D3 - sometimes even hi... 20 Feb 2010 01:30
PPARalpha stimulation limits lymphocyte proliferation As I pointed out several years ago, the mu opioid/cannabinoid complex is under epigenetic control (via OCTN2/butyrate/carnitine uptake) and there was evidence even back then that cannabinoid signals limited lymphocyte proliferation. Now we have more direct evidence of this via PPARalpha, a regulator of OCTN2. ... 18 Feb 2010 07:15
Tribbles and Barrett's esophagus Makes me wonder if Lgr5+ stem cells aren't somehow regulated by a bile acid/VDR pathway. There's evidence from work in hair follicles for a direct connection between vitamin D and hair follicle stem cell maintenance. Makes me think something similar is at work in the gut. Carcinogenesis. 2010 Feb 11 � An i... 18 Feb 2010 02:54
Blueberries plus probiotics vs. IBD http://www.sciencedaily.com/releases/2010/02/100208145055.htm Blueberries Counteract Intestinal Diseases ScienceDaily (Feb. 9, 2010) � It is already known that blueberries are rich in antioxidants and vitamins. New research from the Lund University Faculty of Engineering in Sweden shows that blueberry fibre a... 12 Feb 2010 15:45
More lack of Scientific proof for homeopathy http://www.guardian.co.uk/science/blog/2010/feb/04/homeopathic-association-evidence-commons-committee Homeopathic association misrepresented evidence to MPs Scientists are angry that the British Homeopathic Association cited their research to a committee of MPs as proof homeopathy works when their studies sho... 11 Feb 2010 22:59
Cathlicidin inhibits TNF-alpha Cathelicidin limits TNF-alpha release. Yet another justification for classifying Crohn's, MPB, diabetes and other diseases as forms of cathelicidin deficiency. As noted previously, TNF-alpha/p65 activation inhibit vitamin D3 transcription - which would set up a vicious, self-reinforcing cycle of cathelicidi... 17 Feb 2010 00:37
Biofilms and viruses Makes me wonder if beta amyloid fibers are part of a viral biofilm. <http://www.sciencedaily.com/releases/2010/02/100205115946.htm> Biofilms: Discovery of a New Mechanism of Virus Propagation ScienceDaily (Feb. 5, 2010) � Researchers at the Institut Pasteur and CNRS have shown for the first time that certain... 7 Feb 2010 20:57
DGAT1 and TNFalpha in macrophage/fat inflammation: implications for vitamin D's role in diabetes In this latest research, DGAT1 - an enzyme which manufacturers triglycerides - protects macrophages from inflammation as they scour for dead fat cells. Promoting it might be a good strategy for dealing with the inflammatory complications of obesity. Guess what? If a 1987 study is anything to go by, Vitamin... 7 Feb 2010 01:06 |