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The role of A20 in preventing colitis
<http://www.sciencedaily.com/releases/2010/07/100705081202.htm> First Step to New Therapy for Chronic Bowel Disease ScienceDaily (Aug. 5, 2010) � Scientists associated with VIB (Flanders Institute for Biotechnology) and Ghent University (UGent) have discovered that A20 protein plays an important protective ro... 9 Aug 2010 02:32
Clotting is a part of the innate immune system
Compare this with my previous posts on heparin and heparanase in Crohn's. <http://www.sciencedaily.com/releases/2010/08/100803101920.htm> Fighting Infections With Blood Clots ScienceDaily (Aug. 4, 2010) � A research team at Ludwig-Maximilians-Universitaet in Munich has shown that clot formation within smal... 8 Aug 2010 23:18
Join us in chat! Ostomyland 24/7 Support - Main Meeting Saturday 7th August
Main Chat is Saturday 8pm UK Time which is 3pm EST ish. Have you been told you need an ostomy (colostomy/ileostomy/urostomy) to deal with your condition? Maybe you have already had this surgery and are coping with it? Or maybe a loved one is dealing with this and you want to support them? We are an ostomy sup... 7 Aug 2010 14:46
HIF-1alpha might treat Parkinson's
J Neurochem. 2010 Jul 23 � HIF Prolyl Hydroxylase Inhibition Increases Cell viability and Potentiates Dopamine Release in Dopaminergic Cells. Leander Johansen J, Nikolaj Sager T, Lotharius J, Witten L, Mork A, Egebjerg J, Thirstrup K. Discovery Biology Research, H. Lundbeck A/S, Valby, Denmark. Abstract Hypo... 6 Aug 2010 12:42
prolyl hydroxylase 1 inhibition improves colitis
PHD1 inhibition boosts HIF-1alpha which then boosts cathelicidin synthesis. Iron lowers HIF-1alpha which might explain why iron in drinking water is associated with colitis. Curiously, cobalt also boosts HIF-1alpha and methylcobalamin (methyl-B12) is rich in cobalt. This might tie B12 deficiency together w... 6 Aug 2010 06:06
Glutamine production is knocked out in some IBD
This may finally explain why glutamine and alpha ketoglutarate have been beneficial for patients with inflammatory bowel conditions. http://www.sciencedaily.com/releases/2010/08/100802110825.htm Scientists Target Possible Cause of One Form of Bowel Disease ScienceDaily (Aug. 2, 2010) � A possible cause of ir... 6 Aug 2010 03:56
TB infection of macrophages via eicosanoids
Knocking out PGE2 might serve to limit the function of Tregs, which would help explain why colitis involves not just defective macrophage (innate) response but also an autoantibody problem. http://www.sciencedaily.com/releases/2010/07/100729101603.htm Tuberculosis Advance: Existing Drugs Can Potentially Targe... 5 Aug 2010 22:30
Requesting help tracking down a recent paper on viral infection and DNA repair
There was a recent article describing how a cell deliberately introduces errors into its own DNA to subtly resist viral infection. Somehow sabotaging its own DNA with "noise" renders the cells more resistant to attack. I think it was published in the last couple of months but multiple searches haven't turned ... 2 Aug 2010 02:46
Calcium release via IP3 regulates autophagy
In light of the recent work on VDR agonist lithocholic acid and the lifespan regulation of klotho, this work on calcium is all-the-more interesting. IP3 overactivity would appear to be a weak link when dealing with misfolded proteins as seen in Parkinson's. <http://www.sciencedaily.com/releases/2010/07/100727... 1 Aug 2010 01:57
Heparin improves some bedridden patients
Part of cathelicidin's antiviral effects against CMV are mediated via its affinity for heparan sulfate. It's possible the heparin in this study is interfering with the ability of viruses like CMV to infect cells. Heparin is also neuroprotective [PMID 19953344]. Heparin is also effective against UC [PMID 1704... 30 Jul 2010 03:13
NGF impairs amyloid production
Cell Death Differ. 2010 Jul;17(7):1126-33. Epub 2010 Apr 16. � Does the term 'trophic' actually mean anti-amyloidogenic? The case of NGF. Calissano P, Amadoro G, Matrone C, Ciafre S, Marolda R, Corsetti V, Ciotti MT, Mercanti D, Di Luzio A, Severini C, Provenzano C, Canu N. Institute of Neurobiology and Mole... 26 Jul 2010 21:37
Join us in chat! Ostomyland 24/7 Support - Main Meeting Saturday 24th July
Main Chat is Saturday 8pm UK Time which is 3pm EST ish. Have you been told you need an ostomy (colostomy/ileostomy/urostomy) to deal with your condition? Maybe you have already had this surgery and are coping with it? Or maybe a loved one is dealing with this and you want to support them? We are an ostomy sup... 24 Jul 2010 14:31
Structural brain changes accompany IBS
http://www.sciencedaily.com/releases/2010/07/100722132433.htm Structural Brain Alterations in Patients With Irritable Bowel Syndrome Discovered ScienceDaily (July 22, 2010) � A large academic study has demonstrated structural changes in specific brain regions in female patients with irritable bowel syndrome... 23 Jul 2010 03:49
Physician performance declines markedly with more complex patientproblems
Some tales of medical incompetence by ignorant or arrogant or sometimes just plain exhausted doctors: http://www.dailymail.co.uk/news/article-1296471/Parents-fury-teenage-daughter-dies-just-days-doctors-sent-home-told-paracetamol.html http://www.dailymail.co.uk/news/article-1089891/Judge-slams-hospital-st... 22 Jul 2010 05:58
Arabinogalactan in grass suppresses allergic reactions
http://www.sciencedaily.com/releases/2010/07/100719090936.htm What Protects Farm Children from Hay Fever? Protective Substance May Slumber in Cowshed Dust ScienceDaily (July 19, 2010) � Researchers from Bochum have isolated the substance in cowshed dust that possibly protects farm children from developing a... 20 Jul 2010 22:22
GSK-3beta is manipulated by influenza, herpes
Nature. 2010 Feb 11;463(7282):813-7 Human host factors required for influenza virus replication. Konig R, Stertz S, Zhou Y, Inoue A, Hoffmann HH, Bhattacharyya S, Alamares JG, Tscherne DM, Ortigoza MB, Liang Y, Gao Q, Andrews SE, Bandyopadhyay S, De Jesus P, Tu BP, Pache L, Shih C, Orth A, Bonamy G, Miraglia ... 20 Jul 2010 03:47
Physician performance declines markedly with more complex patient problems
http://www.sciencedaily.com/releases/2010/07/100719174905.htm Physicians Can Perform Poorly When Patients Need Special Care, Study Suggests ScienceDaily (July 19, 2010) � Patients often receive inappropriate care when their doctors fail to take into account their individual circumstances, according to a new... 24 Jul 2010 04:49
New model of vitamin D3 consumption, requirements
http://www.sciencedaily.com/releases/2010/06/100618112133.htm Model Predicts Individual's Vitamin D Needs ScienceDaily (July 17, 2010) � Your skin tone and the amount of sunshine you receive--in addition to what foods you eat--all can influence the amount of vitamin D that your body has on hand for optimum he... 19 Jul 2010 21:18
Drinking water stimulates the sympathetic nervous system
http://www.sciencedaily.com/releases/2010/07/100706150639.htm Water's Unexpected Role in Blood Pressure Control ScienceDaily (July 14, 2010) � Name a drink that can make you more alert for late-night studying, prevent you from fainting after giving blood, and even promote a teensy bit of weight loss. Cha... 18 Jul 2010 02:01
Vitamin D can induce tPA secretion
Am J Physiol Endocrinol Metab. 2000 Feb;278(2):E293-301 � Induction of tissue plasminogen activator secretion from rat heart microvascular cells by fM 1,25(OH)(2)D(3). Puri S, Bansal DD, Uskokovic MR, MacGregor RR. Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas ... 16 Jul 2010 04:30
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