IBS

HDACs regulate contraction by sensitizing heart muscle to calcium; might explain mercury accumulation in cardiomyopathy
For quite a while now, mercury accumulation has been observed in the heart muscle of patients with cardiomyopathy (heart failure). I believe we finally have a good explanation for why this occurs. It turns out that heart muscle contraction is directly regulated by histone acetylation. HDAC inhibitors sensiti... 16 Apr 2008 02:40

Hookworms, anemia, autoimmunity and the HIF-1/EPO/cathelicidin pathway induced by iron deficiency
Recently published research shows that hyrdoxylase inhibitors have gastroprotective properties through the induction of HIF-1a, thus making them a potential medication for leaky gut problems [PMID 18166353, 18166352]. Low iron conditions and iron chelators like EGCG also activate HIF-1a, as does cobalt chlorid... 14 Apr 2008 04:44

Treat the symptoms and more importantly the cause.
Treat the symptoms and more importantly the cause. Do you feel like you are in a TAXI cab being driven around and around in circles, or the system is taking the long way around to find a solution to YOUR problem. Well YOUR problem, is making SOME alot of money, and the cause of your illness may be a simple inf... 13 Apr 2008 21:34

How do you deal with it socially?
I'm taking a chance here, because I feel there's a remote chance anybody is going to reply. My social life is dismal, I'm here on my day off on a saturday night, and I have nothing to do. I haven't made a new friend in 7 years, since my symptoms started surfacing. I'm afraid of how I'll be received if I say ''Hey p... 12 Apr 2008 19:06

Some comments about acidic vs. basic diets
I wish to refine and extend my remarks on this interesting paper. This paper indicates that chronic pain and fatigue may be due to a lack of signalling through acid-sensing ion channel 3 (ASIC3) in muscles. Testosterone is required to make that channel work, which may explain why women are more likely to get ... 12 Apr 2008 00:39

Cupping and Pure salt Therapy for IBS
Cupping and Pure Salt therapy is a unique, safe and effective alternative medicine for the treatment of many diseases by cleaning the blood and promoting blood circulation. Diseases that can be treated include IBS, constipation, diarrhea, stroke, heart disease, angina, hypertension (high blood pressure), high chole... 9 Apr 2008 12:12

Testosterone reduces muscle pain and fatigue via ASIC3
Given the interaction of p75 with ASIC3, a receptor upregulated by acetyl-l-carnitine, I think this new result explains how ALCAR provides clinical relief for chronic fatigue sufferers (it's a shame ALCAR sends hair into catagen through the same receptor and also alters cancer risks the same way; perhaps ASIC3 ... 9 Apr 2008 00:33

Caffeine blocks the blood-brain barrier dysfunction caused by high cholesterol
Zonulin is also involved in the barrier function of the gut, especially in celiac disease. However, caffeine may block regulatory T-cells via its elevation of neutral endopeptidase. NEP blocks vasoactive intestinal polypeptide and VIP is an on signal for Tregs. Caffeine can also adversely affect circadian rh... 8 Apr 2008 22:56

IBS and the liver connection.
IBS and the liver connection. The liver, the largest internal organ, does two important things, it filters the blood and creates a great many 'enzymes' in bile to help in the digestive system. Well can you figure it out... A diseased liver can cause many things....including symptoms that may be labelled as ... 6 Apr 2008 08:46

Potential benefits of cathelicidin (vitamin D3) vs. sinusitis
Laryngoscope. 2008 Jan 30; [Epub ahead of print] � An Antimicrobial Peptide Modulates Epithelial Responses to Bacterial Products. Vonk MJ, Hiemstra PS, Grote JJ. From the departments of Otorhinolaryngology (m.j.v., j.j.g.) and Pulmonology (p.s.h.), Leiden University Medical Center, Leiden, The Netherlands, ... 5 Apr 2008 20:32