IBS

The role of macrophages in brain inflammation
<http://www.sciencedaily.com/releases/2010/01/100113122301.htm> Dual Role for Immune Cells in the Brain ScienceDaily (Jan. 13, 2010) � We all have at one time or another experienced the typical signs of an infection: the fever, the listlessness, the lack of appetite. They are orchestrated by the brain in re... 14 Jan 2010 21:26

TLR2 regulates intestinal permeability
This might help link general sympathetic innervation in IBD and a number of other disorders involving tight junction gaps (esp. the blood-brain barrier). Cell Microbiol. 2008 Feb;10(2):388-403. Epub 2007 Oct 2. Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter r... 12 Jan 2010 08:18

Bifidobacterium proteins enhance intestinal barrier function
Am J Physiol Gastrointest Liver Physiol. 2008 Nov;295(5):G1025-34. Epub 2008 Sep 11 � Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function. Ewaschuk JB, Diaz H, Meddings L, Diederichs B, Dmytrash A, Backer J, Looijer-van Langen M, Madsen KL. Univ. of Alberta, Edmon... 12 Jan 2010 08:18

Mesenchymal stem cells in the treatment of inflammatory bowel disease
J Pathol. 2009 Jul;218(3):350-9 Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity. Yabana T, Arimura Y, Tanaka H, Goto A, Hosokawa M, Nagaishi K, Yamashita K, Yamamoto H, Adachi Y, Sasaki Y, Isobe M, Fujimiya M, Imai K, Shinomura Y. First Department of Inter... 12 Jan 2010 08:18

Cathelicidin as a BMP-inducer via proteasome inhibition
I've been waiting for this link to come out for a long time. Since the Fall of 2008, I've suspected cathelicidin acts directly on BMP-7 and, lately, I've come to suspect it's part of a sympathoadrenal regulatory network involving Nurr1/NGFI-Bbeta and controlling dopamine production. All this is part of its in... 11 Jan 2010 02:12

XMRV may not be culprit in chronic fatigue after all
Doh! <http://www.sciencedaily.com/releases/2010/01/100106003615.htm> New Virus Is Not Linked to Chronic Fatigue Syndrome, Suggests New Research ScienceDaily (Jan. 6, 2010) � New UK research, published in PLoS ONE, has not reproduced previous findings that suggested Chronic Fatigue Syndrome may be linked ... 9 Jan 2010 04:15

Having trouble dealing with Irritable Bowel Syndrome?
I myself have severe case of IBS. Its tough to try adapting to the lifestyle and I know how hard to journey is. The first thing you should do is to see a gastroenterologist and make sure what you have is IBS and not similar disorders. If you are certain that you suffer from IBS then it's time to change your styl... 7 Jan 2010 00:22

Methotrexate as an HDAC inhibitor
How much of methotrexate's benefits in cancer and autoimmunity are due to HDAC inhibition and how much due to dihydrofolate reductase inhibition? I wonder if EGCG also displays this same activity. Biochem Biophys Res Commun. 2009 Dec 21 � Inhibition of histone deacetylase activity is a novel function of the... 6 Jan 2010 10:00

HDAC1 upregulation in neurodegneration impairs neuronal mitochondrial transport
This points to a defective OCTN2/carnitine/butyrate uptake mechanism which perhaps accounts for the gender bias in multiple sclerosis. Testosterone is a carnitine transporter and given how the movement of mitochondria is vital in neurotransmission, this might help link testosterone and NGF signaling. In any c... 3 Jan 2010 07:17

Marijuana appears to counterintuitively restore GI barrier integrity in colitis
The only drek I know is the Gary R.Schmidt on this group. You are the one that discourages people from at least looking into a method that may help their crohns or UC. Too bad, but our opposite views are important to some that are not closed to the unusual method of developing crohns and UC. "Gary R. Schm... 6 Jan 2010 10:00