Hypothesis Of Polycythaemic Excess
in [Lupus]
|
From: ironjustice on 9 Jul 2008 20:05 Chorea and lupus are linked / differential diagnosis. They tell us to check FOR lupus when there IS chorea. Polycythemia / erythrocytosis / iron excess CAUSES chorea. AGAIN polycythemia / erythrocytosis / iron excess linked to .. lupus. Coincidence .. AGAIN .. of course. http://tinyurl.com/6d73cp Vol. 23, No. 1, 1984 Paper Chorea and Polycythaemia G.W. Bruyn, G. Padberg Department of Neurology (Chairman: G.W. Bruyn), Academic Hospital, State University Leiden, The Netherlands Address of Corresponding Author Eur Neurol 1984;23:26-33 (DOI: 10.1159/000115674) -------------------------------------------------------------------------------- Key Words Chorea Polycythaemia Catecholestrogen Hyperviscosity syndrome Dopamine -------------------------------------------------------------------------------- Abstract An analysis is presented of 35 cases of chorea as a symptom of polycythaemia. This analysis reveals: (a) whereas polycythaemia occurs predominantly in males (3:2), poly-cythaemic chorea (PC) occurs predominantly in females (5:2), at a real ratio of : = 4:1, the prevalence being 1-2.5% of polycythaemic patients; (b) PC manifests predominantly after the age of 50 (8 cases before, 27 after 50 years), making polycythaemia the first disorder to be considered in cases of so-called 'senile' chorea; (c) PC is generalised, with predominant involvement of faciolingual and brachial muscles, and associated with muscular hypotonia; (d) PC may last from periods of weeks to years, usually responds to haloperidol, venesection or 32P-treatment, but may persist, or recur with treatment, or remit spontaneously, and (e) no relationship exists between the choreatic syndrome and (the rare finding of) a small infarct in the caudate nucleus. The cause of the choreatic syndrome in polycythaemia is presumably to be explained as a neostriatal hyperviscosity syndrome producing venous stasis, reduced brain blood flow and impaired tissular CVglucose metabolism. The state of dopaminergic hyperactivity is presumably enhanced by relatively increased neostriatal catecholestrogens. The hypothesis of polycythaemic excess of dopamine-laden platelets releasing excess of dopamine in the neostriatum needs to be confirmed by laboratory evidence of platelet counts. Copyright © 1984 S. Karger AG, Basel Author Contacts Prof. Dr. med. G.W. Bruyn, Rijnsburgerweg 10, NL-2333 AA Leiden (The Netherlands) -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
From: ironjustice on 13 Jul 2008 02:37 On Jul 9, 5:05 pm, ironjustice <teamtan...(a)hotmail.com> wrote: chorea << Polycythemia causes iron overload and chorea. This article siderosis causing chorea gives evidence to iron **causing** the chorea. [Superficial hemosiderosis of the central nervous system improved by corticosteroids] Mar 2008 E Le Rhun,G Soto Ares,N Pécheux,A Destée,L Defebvre INTRODUCTION: Superficial siderosis is of the Central Nervous System (CNS) is an uncommon and often disabling disorder. There is no evidence that any treatment, including removal of an identified source of bleeding, affects disease progression. OBSERVATION: We report the case of a 49-year-old woman exhibiting progressive and various neurological disorders associating chorea, pyramidal syndrome, cerebellar ataxia, cognitive disorders and cranial nerve deficits. She had a prior history of right occipital arterioveinous malformation (AVM) revealed four years before by ventricular hemorrhage. The AVM was treated by radiosurgery. Because of a pronounced progression of the symptoms, treatment with steroid therapy was initiated before the diagnosis of siderosis of the central nervous system was asserted by magnetic resonance imaging (rim of hypo-intensity due to hemosiderin around the brainstem, the cerebellum and the spinal cord on T-2 weighted and gradient echo T-2* imaging) and cerebrospinal fluid (CSF) examination (high CSF levels of iron and ferritin). Over the next months the neurological condition improved under steroid therapy. CONCLUSION: Our observation is interesting because of the chorea movement disorders which are rarely reported in the disease and because of the improvement of the neurological condition after steroid therapy which is described in only another case in the literature. Steroid therapy could constitute a new track for the treatment of siderosis of CNS. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Choreaandlupusare linked / differential diagnosis. > They tell us to check FORlupuswhen there ISchorea. > Polycythemia / erythrocytosis / iron excess CAUSESchorea. > AGAIN polycythemia / erythrocytosis / iron excess linked to ..lupus. > > Coincidence .. AGAIN .. of course. > > http://tinyurl.com/6d73cp > > Vol. 23, No. 1, 1984 > > PaperChoreaand Polycythaemia > G.W. Bruyn, G. Padberg > > Department of Neurology (Chairman: G.W. Bruyn), Academic Hospital, > State University Leiden, The Netherlands > > Address of Corresponding Author > Eur Neurol 1984;23:26-33 (DOI: 10.1159/000115674) > > -------------------------------------------------------------------------------- > Key Words > > Chorea > Polycythaemia > Catecholestrogen > Hyperviscosity syndrome > Dopamine > > -------------------------------------------------------------------------------- > Abstract > An analysis is presented of 35 cases ofchoreaas a symptom of > polycythaemia. This analysis reveals: (a) whereas polycythaemia occurs > predominantly in males (3:2), poly-cythaemicchorea(PC) occurs > predominantly in females (5:2), at a real ratio of : = 4:1, the > prevalence being 1-2.5% of polycythaemic patients; (b) PC manifests > predominantly after the age of 50 (8 cases before, 27 after 50 years), > making polycythaemia the first disorder to be considered in cases of > so-called 'senile'chorea; (c) PC is generalised, with predominant > involvement of faciolingual and brachial muscles, and associated with > muscular hypotonia; (d) PC may last from periods of weeks to years, > usually responds to haloperidol, venesection or 32P-treatment, but may > persist, or recur with treatment, or remit spontaneously, and (e) no > relationship exists between the choreatic syndrome and (the rare > finding of) a small infarct in the caudate nucleus. The cause of the > choreatic syndrome in polycythaemia is presumably to be explained as a > neostriatal hyperviscosity syndrome producing venous stasis, reduced > brain blood flow and impaired tissular CVglucose metabolism. The state > of dopaminergic hyperactivity is presumably enhanced by relatively > increased neostriatal catecholestrogens. The hypothesis of > polycythaemic excess of dopamine-laden platelets releasing excess of > dopamine in the neostriatum needs to be confirmed by laboratory > evidence of platelet counts. > Copyright © 1984 S. Karger AG, Basel > > Author Contacts > Prof. Dr. med. G.W. Bruyn, Rijnsburgerweg 10, NL-2333 AA Leiden (The > Netherlands) > > -------------------------------------------------------------------------------- > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
|
Pages: 1 Prev: Poll: Which newsreader are you using? Next: having heart cath |