Hormone Depletion and Fatigue
in [Thyroid]
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From: ironjustice on 17 Jul 2008 22:54 "Hypothyroidism appears to be an authentic cause" Ann Endocrinol (Paris). 2008 Jul 4 Severe rhabdomyolysis revealing a myopathy linked to autoimmune hypothyroidism. Mouzouri H, El Omri N, Sekkach Y, Frikh R, Nzambe C, Qacif H, Baizri H, Makouar F, Qatni ME, Belmejdoub G, Rkiouak F, Ghafir D, Ohayon V, Archane MI. UFR d'endocrinologie, service de médecine B2, hôpital militaire d'instruction Med-V, faculté de médecine et de pharmacie, 10000 Rabat, Maroc. While muscular manifestations are common of hypothyroidism, hypothyroid myopathy is most often limited to myalgia, muscular stiffness and cramps with, in some patients, elevated levels of muscle enzymes. We report two cases of rhabdomyolysis related to hypothyroid myopathy. One of the patients developed acute renal failure. Thyroid hormone replacement therapy improved thyroid and renal function with involution of rhabdomyolysis. Hypothyroidism appears to be an authentic cause of rhabdomyolysis and should be carefully ruled out in all patients with elevated serum levels of muscle enzymes. Publication Types: LETTER PMID: 18603225 Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
From: Rod on 18 Jul 2008 02:49 ironjustice wrote: > "Hypothyroidism appears to be an authentic cause" > > Ann Endocrinol (Paris). 2008 Jul 4 > Severe rhabdomyolysis revealing a myopathy linked to autoimmune > hypothyroidism. > Mouzouri H, El Omri N, Sekkach Y, Frikh R, Nzambe C, Qacif H, Baizri > H, Makouar F, Qatni ME, Belmejdoub G, Rkiouak F, Ghafir D, Ohayon V, > Archane MI. > Do you have access to the full article/letter? Without being able to read that, it is impossible to know if statins are involved - as they have been in several earlier cases of rhabdomyolysis. -- Rod Hypothyroidism is a seriously debilitating condition with an insidious onset. Although common it frequently goes undiagnosed. <www.thyromind.info> <www.thyroiduk.org> <www.altsupportthyroid.org>
From: ironjustice on 18 Jul 2008 16:41 On Jul 17, 11:49 pm, Rod <polygo...(a)ntlworld.com> wrote:Do you have access to the full article/letter? << Nope .. ------------------------------- Mood Swings, Depression, Impotence, Infertility, possible effects of excess iron accumulation in the pituitary Located in the brain, at the base of the hyopthalamus is a small round gland about the size of a garden pea, called the pituitary. Sometimes referred to as the master gland, it is key to the highly complex endocrine system which includes adrenals, pancreas, kidneys, parathyroid, thyroid, testes and ovaries. Among the functions of the pituitary is the production of hormones that help to regulate growth, reproduction and certain metabolic processes. The anterior lobe or front side of the pituitary produces hormones that regulate growth and physical development. It also stimulates adrenal function, thyroid gland and reproductive organs. The backside or posterior lobe produces hormones that regulate water balance and stimulate contractions of the uterus and the let-down response in lactating females. Hormones secreted by the pituitary are carried through the bloodstream to its target organ. When the pituitary is dysfunctional and secretion of hormones is excessive or insufficient, imbalances can lead to a number of conditions where mood, sexuality, and growth are compromised and can be observed as short stature, infertility, impotence and depression. In hereditary hemochromatosis, a genetic disorder of metabolism, iron is absorbed in excess and accumulates in tissues of various organs and glands that can include the pituitary. A disease that can result from excessive accumulation of iron in the pituitary is hypothyroidism. Symptoms of chronic fatigue, loss of libido (sex drive), moodiness, low blood pressure, slow pulse, reduced temperature, cool dry skin, brittle nails, hair loss, weight gain, puffy face-eyes dark circles under the eyes, ataxia, aching muscles, joint stiffness and intolerance to cold are among the symptoms with this disease. According to Scientific Review Board Dr. James Connor, "Hormonal imbalance may be expected due to abnormal iron accumulation in the pituitary. Because the pituitary is responsible for production of hormones and hormones can effect mood and behavior in general, it follows that mood swings and even depression could stem from a hormonal imbalance secondary to iron accumulation in the pituitary. Though the actual data are not there to draw on an evidence-based conclusion, clearly, iron accumulation in the pituitary could influence hormonal release and subsequently contribute to the mood swings, impotence and infertility. Depression is less clear but certainly possible". The causative source of organ and gland dysfunction or damage is still anyone's guess. Give the insidious nature of iron accumulation throughout the body and the known damage that can result, when impotence, infertility, depression or diabetes are present, physicians who do not check iron levels might well be doing a disservice to the patients. Dr. Connor points out "depression and diabetes could also be associated to direct iron accumulation in the specific organs (diabetes especially) rather than an indirect hormonal link." Because so much is unknown about how iron imbalances contribute to disease, the importance of getting the correct tests including fasting serum ferritin and transferrin iron saturation percentage. Dr. Connor further points out "MRI's cannot be stressed enough for individuals with hemochromatosis (HHC)." Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
From: Sha1 on 29 Jul 2008 01:36 On Jul 19, 6:41 am, ironjustice <ironjust...(a)cashette.com> wrote: > On Jul 17, 11:49 pm, Rod <polygo...(a)ntlworld.com> wrote:Do you have > access to the full article/letter? << > > Nope .. > ------------------------------- > Mood Swings, Depression, Impotence, Infertility, > possible effects of excess iron accumulation in the pituitary > > Located in the brain, at the base of the hyopthalamus is a small > round > gland about the size of a garden pea, called the pituitary. > Sometimes > referred to as the master gland, it is key to the highly complex > endocrine > system which includes adrenals, pancreas, kidneys, parathyroid, > thyroid, testes and ovaries. Among the functions of the pituitary is > the > production of hormones that help to regulate growth, reproduction and > certain metabolic processes. > > The anterior lobe or front side of the pituitary produces hormones > that > regulate growth and physical development. It also stimulates adrenal > function, thyroid gland and reproductive organs. The backside or > posterior > lobe produces hormones that regulate water balance and stimulate > contractions of the uterus and the let-down response in lactating > females. > > Hormones secreted by the pituitary are carried through the bloodstream > to > its target organ. When the pituitary is dysfunctional and secretion > of > hormones is excessive or insufficient, imbalances can lead to a number > of > conditions where mood, sexuality, and growth are compromised and can > be observed as short stature, infertility, impotence and depression. > > In hereditary hemochromatosis, a genetic disorder of metabolism, iron > is > absorbed in excess and accumulates in tissues of various organs and > glands > that can include the pituitary. A disease that can result from > excessive > accumulation of iron in the pituitary is hypothyroidism. Symptoms of > chronic fatigue, loss of libido (sex drive), moodiness, low blood > pressure, > slow pulse, reduced temperature, cool dry skin, brittle nails, hair > loss, > weight gain, puffy face-eyes dark circles under the eyes, ataxia, > aching > muscles, joint stiffness and intolerance to cold are among the > symptoms > with this disease. > > According to Scientific Review Board Dr. James Connor, "Hormonal > imbalance > may be expected due to abnormal iron accumulation in the pituitary. > Because the pituitary is responsible for production of hormones and > hormones can effect mood and behavior in general, it follows that > mood > swings and even depression could stem from a hormonal imbalance > secondary to iron accumulation in the pituitary. Though the actual > data are > not there to draw on an evidence-based conclusion, clearly, iron > accumulation > in the pituitary could influence hormonal release and subsequently > contribute > to the mood swings, impotence and infertility. Depression is less > clear but > certainly possible". > > The causative source of organ and gland dysfunction or damage is > still > anyone's guess. Give the insidious nature of iron accumulation > throughout > the body and the known damage that can result, when impotence, > infertility, depression or diabetes are present, physicians who do not > check > iron levels might well be doing a disservice to the patients. Dr. > Connor > points out "depression and diabetes could also be associated to > direct > iron accumulation in the specific organs (diabetes especially) rather > than > an indirect hormonal link." Because so much is unknown about how > iron imbalances contribute to disease, the importance of getting the > correct tests including fasting serum ferritin and transferrin iron > saturation > percentage. Dr. Connor further points out "MRI's cannot be stressed > enough for individuals with hemochromatosis (HHC)." > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk Not 2 mention Blood Tests,Blood Gasses as well?These R important in actually discovering which Hormones R depleated,or need Replacing.MRIs alone cannot diagnose this or any condition/s,but R very useful in helping 2 monitor an individual with this & other conditions.
From: Dee on 29 Jul 2008 06:42
"Sha1" <icefire9(a)bigpond.com> wrote in message news:2b8b34eb-2dca-4563-b221-3afd29e69ec2(a)d45g2000hsc.googlegroups.com... On Jul 19, 6:41 am, ironjustice <ironjust...(a)cashette.com> wrote: > On Jul 17, 11:49 pm, Rod <polygo...(a)ntlworld.com> wrote:Do you have > access to the full article/letter? << > > Nope .. > ------------------------------- > Mood Swings, Depression, Impotence, Infertility, > possible effects of excess iron accumulation in the pituitary > > Located in the brain, at the base of the hyopthalamus is a small > round > gland about the size of a garden pea, called the pituitary. > Sometimes > referred to as the master gland, it is key to the highly complex > endocrine > system which includes adrenals, pancreas, kidneys, parathyroid, > thyroid, testes and ovaries. Among the functions of the pituitary is > the > production of hormones that help to regulate growth, reproduction and > certain metabolic processes. > > The anterior lobe or front side of the pituitary produces hormones > that > regulate growth and physical development. It also stimulates adrenal > function, thyroid gland and reproductive organs. The backside or > posterior > lobe produces hormones that regulate water balance and stimulate > contractions of the uterus and the let-down response in lactating > females. > > Hormones secreted by the pituitary are carried through the bloodstream > to > its target organ. When the pituitary is dysfunctional and secretion > of > hormones is excessive or insufficient, imbalances can lead to a number > of > conditions where mood, sexuality, and growth are compromised and can > be observed as short stature, infertility, impotence and depression. > > In hereditary hemochromatosis, a genetic disorder of metabolism, iron > is > absorbed in excess and accumulates in tissues of various organs and > glands > that can include the pituitary. A disease that can result from > excessive > accumulation of iron in the pituitary is hypothyroidism. Symptoms of > chronic fatigue, loss of libido (sex drive), moodiness, low blood > pressure, > slow pulse, reduced temperature, cool dry skin, brittle nails, hair > loss, > weight gain, puffy face-eyes dark circles under the eyes, ataxia, > aching > muscles, joint stiffness and intolerance to cold are among the > symptoms > with this disease. > > According to Scientific Review Board Dr. James Connor, "Hormonal > imbalance > may be expected due to abnormal iron accumulation in the pituitary. > Because the pituitary is responsible for production of hormones and > hormones can effect mood and behavior in general, it follows that > mood > swings and even depression could stem from a hormonal imbalance > secondary to iron accumulation in the pituitary. Though the actual > data are > not there to draw on an evidence-based conclusion, clearly, iron > accumulation > in the pituitary could influence hormonal release and subsequently > contribute > to the mood swings, impotence and infertility. Depression is less > clear but > certainly possible". > > The causative source of organ and gland dysfunction or damage is > still > anyone's guess. Give the insidious nature of iron accumulation > throughout > the body and the known damage that can result, when impotence, > infertility, depression or diabetes are present, physicians who do not > check > iron levels might well be doing a disservice to the patients. Dr. > Connor > points out "depression and diabetes could also be associated to > direct > iron accumulation in the specific organs (diabetes especially) rather > than > an indirect hormonal link." Because so much is unknown about how > iron imbalances contribute to disease, the importance of getting the > correct tests including fasting serum ferritin and transferrin iron > saturation > percentage. Dr. Connor further points out "MRI's cannot be stressed > enough for individuals with hemochromatosis (HHC)." > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk I skimmed through the article (that's about all I can handle right now because my concentration is very poor); and I see pituitary mentioned, and iron accumulation. When I received my diagnosis of Hashimoto's in April 08, my prolactin was high. I'm also long-term anemic (so maybe that's where all my iron is going? Sort of kidding...) My first blood work is in two weeks (I've only been on thyroid medication for one month). We'll check the thyroid, my ferritin, and we're going to see what's happening with the pituitary gland. If my prolactin levels don't go down (eventually?), apparently we're thinking tumour(s). I also have had fibromyalgia symptoms since 1994 (that I can recall). Dee |