Herpesviruses secrete phony IL-10; might cause autoimmune risk
in [Colitis]
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From: Kofi on 30 Sep 2008 02:31 IL-10 is a cytokine vital to the functioning of regulatory T-cells (Tregs). When I found out I had a raging CMV infection<1>, I ran a literature search cross-referencing members of the herpesvirus family with vitamin D3 to see if I could explain why oral supplementation with D3 is much less effective for me than UV exposure. Well, it turns out my hunch might be right. CMV interferes with at least one pathway downstream of vitamin D3 - namely, IL-10. There's precious little on it in the literature, though. <1> An infection which improved when I quit eating turkey, by the way. IDO degrades tryptophan and has antiviral and antimicrobial properties. IDO can be blocked by surplus tryptophan - which you can find in turkey. Med Hypotheses. 2008;71(1):85-90. � A unifying multiple sclerosis etiology linking virus infection, sunlight, and vitamin D, through viral interleukin-10. Hayes CE, Donald Acheson E. Department of Biochemistry, University of Wisconsin, Madison, 433 Babcock Drive, Madison, WI 53706, USA. Multiple sclerosis (MS) is a neurodegenerative disease of uncertain etiology. In MS, neurodegeneration is thought to be secondary to autoimmune-mediated damage. However, no cohesive explanation yet exists as to how environmental factors interact to induce a neurodegenerative autoimmune response. Insufficient sunlight exposure and chronic viral infections have been proposed as unrelated environmental risk factors for MS. We suggest that these risk factors may act synergistically to enable the pathogenic autoimmune response. Low ultraviolet light (UVL) exposure depletes vitamin D3 stores, and low vitamin D3 levels correlate strongly with high MS risk. The central nervous system converts vitamin D3 into 1,25-dihydroxyvitamin D3 (1,25-(OH)2 D3), a biologically active hormone with anti-inflammatory and neuro-protective functions that depend on IL-10-producing regulatory lymphocytes. Herpesvirus infection also correlates with MS risk. Some herpesviruses like Epstein-Barr virus produce an IL-10-like cytokine termed vIL-10. We hypothesize that vIL-10 may induce a dysfunction of IL-10-producing regulatory lymphocytes, thereby undermining the protective functions of sunlight, vitamin D3, and 1,25-(OH)2 D3. The vIL-10 could elicit a host immune response capable of neutralizing or depleting IL-10, or the vIL-10 could compete with IL-10 but fail to perform an essential IL-10 function. In either case, the lack of sunlight exposure and the herpes virus infection might synergize to induce a defect in IL-10-producing regulatory lymphocyte function that undermines self-tolerance mechanisms and enables a pathogenic autoimmune response to neural proteins. Publication Types: * Research Support, Non-U.S. Gov't PMID: 18387750
From: Robert Miles on 30 Sep 2008 04:04 "Kofi" <kofi(a)anon.un> wrote in message news:kofi-E026EB.01311130092008(a)news.east.earthlink.net... > IL-10 is a cytokine vital to the functioning of regulatory T-cells > (Tregs). When I found out I had a raging CMV infection<1>, I ran a > literature search cross-referencing members of the herpesvirus family > with vitamin D3 to see if I could explain why oral supplementation with > D3 is much less effective for me than UV exposure. Well, it turns out > my hunch might be right. CMV interferes with at least one pathway > downstream of vitamin D3 - namely, IL-10. There's precious little on it > in the literature, though. > [snip] Have you found this yet? http://en.wikipedia.org/wiki/Interleukin
From: Kofi on 1 Oct 2008 02:53 In article <s2lEk.41925$rD2.26753(a)bignews4.bellsouth.net>, "Robert Miles" <robertmiles(a)bellsouthNOSPAM.net> wrote: > http://en.wikipedia.org/wiki/Interleukin How does this relate to virally produced faux IL-10 and interference in vitamin D3 metabolism?
From: Robert Miles on 1 Oct 2008 08:37 "Kofi" <kofi(a)anon.un> wrote in message news:kofi-450F75.01530601102008(a)news.west.earthlink.net... > In article <s2lEk.41925$rD2.26753(a)bignews4.bellsouth.net>, "Robert > Miles" <robertmiles(a)bellsouthNOSPAM.net> wrote: > >> http://en.wikipedia.org/wiki/Interleukin > > How does this relate to virally produced faux IL-10 and interference in > vitamin D3 metabolism? .. It's one of the few web sites I've found that even mention IL-10. I believe all of the others were found in a quick look through newsgroup alt.support.crohns-colitis. Note that Google searches seldom find newsgroup posts now; they used to.
From: Robert Miles on 1 Oct 2008 10:48
"Robert Miles" <robertmiles(a)bellsouthNOSPAM.net> wrote in message news:%7KEk.43219$vX2.1218(a)bignews6.bellsouth.net... > > "Kofi" <kofi(a)anon.un> wrote in message > news:kofi-450F75.01530601102008(a)news.west.earthlink.net... >> In article <s2lEk.41925$rD2.26753(a)bignews4.bellsouth.net>, "Robert >> Miles" <robertmiles(a)bellsouthNOSPAM.net> wrote: >> >>> http://en.wikipedia.org/wiki/Interleukin >> >> How does this relate to virally produced faux IL-10 and interference in >> vitamin D3 metabolism? > . > It's one of the few web sites I've found that even mention IL-10. > > I believe all of the others were found in a quick look through newsgroup > alt.support.crohns-colitis. Note that Google searches seldom find > newsgroup posts now; they used to. > I tried a Google search for "IL-10 Virus" without the quotes; this found more: http://www.pnas.org/content/98/24/13913.full http://www.nature.com/mt/journal/v11/n1s/abs/mt2005248a.html http://ajrccm.atsjournals.org/cgi/content/abstract/161/5/1518 <http://www.ingentaconnect.com/content/ap/vy/1998/00000245/00000002/art09170;jsessionid=1g1k9raq1do2p.alice?format=print> http://www.ncbi.nlm.nih.gov/pubmed/12606512 <http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXR-45HR3WJ-9V&_user=4420034&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=4420034&md5=9e65391ed8126637dc5d0dd82083787e> http://diabetes.diabetesjournals.org/cgi/reprint/52/3/708.pdf http://cat.inist.fr/?aModele=afficheN&cpsidt=18021365 Google seems to have improved its results for searches for IL-10. I found these: <http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=gene&list_uids=3586> http://www.ncbi.nlm.nih.gov/pubmed/10623821 http://www1.va.gov/environagents/docs/IL-10-2007-001_Sarcoid.pdf http://www.genenames.org/data/hgnc_data.php?hgnc_id=5962 http://www.dsi.univ-paris5.fr/genatlas/fiche.php?symbol=IL10 http://expasy.org/uniprot/P22301 http://www.uniprot.org/uniprot/P22301 |