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From: Kofi on 20 May 2008 22:18
An allele for autophagy is associated with autoimmune digestive
disorders. Butyrate is an HDAC inhibitor and uptake of butyrate can be
impaired in inflammatory gut injuries or via antibiotic usage as
friendly gut bacteria produce butyrate.

Biochem Biophys Res Commun. 2008 May 16;369(4):1179-83. Epub 2008 Mar 13.

Inhibition of histone deacetylase1 induces autophagy.

Oh M, Choi IK, Kwon HJ.

Chemical Genomics Laboratory, Department of Biotechnology, Yonsei
Biomedical Science and Technology Initiative, College of Life Science &
Biotechnology, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul
120-749, Republic of Korea.

Autophagy is a process where cytoplasmic materials are degraded by
lysosomal machinery. Histone deacetylase (HDAC) inhibitors induce
autophagy, and HDAC6, one of class II HDAC isotypes, is directly
involved in autophagic degradation in the cell. However, it is unclear
if class I HDAC isotype such as HDCA1 is involved in this process. To
investigate if class I HDAC isotype is involved in autophagy, a specific
class I HDAC inhibitor and an siRNA of HDAC1 were used to treat HeLa
cells. Autophagic markers were then investigated. Both inhibition and
genetic knock-down of HDAC1 in the cells significantly induced
autophagic vacuole formation and lysosome function. Moreover, disruption
of HDAC1 leads to the conversion of LC3-I to LC3-II. Together, these
results demonstrate that HDAC1 could play a role in autophagy and
specific inhibition of HDAC1 can induce autophagy.

Publication Types:
* Research Support, Non-U.S. Gov't

PMID: 18342621
From: Bob Arnold on 20 May 2008 22:58
In article <kofi-8B4FA5.21180620052008(a)news.east.earthlink.net>,
Kofi <kofi(a)anon.un> wrote:

> An allele for autophagy is associated with autoimmune digestive
> disorders. Butyrate is an HDAC inhibitor and uptake of butyrate can be
> impaired in inflammatory gut injuries or via antibiotic usage as
> friendly gut bacteria produce butyrate.
>
> Biochem Biophys Res Commun. 2008 May 16;369(4):1179-83. Epub 2008 Mar 13.
>
> Inhibition of histone deacetylase1 induces autophagy.
>
> Oh M, Choi IK, Kwon HJ.
>
> Chemical Genomics Laboratory, Department of Biotechnology, Yonsei
> Biomedical Science and Technology Initiative, College of Life Science &
> Biotechnology, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul
> 120-749, Republic of Korea.
>
> Autophagy is a process where cytoplasmic materials are degraded by
> lysosomal machinery. Histone deacetylase (HDAC) inhibitors induce
> autophagy, and HDAC6, one of class II HDAC isotypes, is directly
> involved in autophagic degradation in the cell. However, it is unclear
> if class I HDAC isotype such as HDCA1 is involved in this process. To
> investigate if class I HDAC isotype is involved in autophagy, a specific
> class I HDAC inhibitor and an siRNA of HDAC1 were used to treat HeLa
> cells. Autophagic markers were then investigated. Both inhibition and
> genetic knock-down of HDAC1 in the cells significantly induced
> autophagic vacuole formation and lysosome function. Moreover, disruption
> of HDAC1 leads to the conversion of LC3-I to LC3-II. Together, these
> results demonstrate that HDAC1 could play a role in autophagy and
> specific inhibition of HDAC1 can induce autophagy.
>
> Publication Types:
> * Research Support, Non-U.S. Gov't
>
> PMID: 18342621


Kofi,

You take sodium butyrate right? Where do you get it?

Thanks.

Bob
From: sbarsell on 21 May 2008 17:05
On May 20, 4:58 pm, Bob Arnold <nos...(a)aol.com> wrote:
> In article <kofi-8B4FA5.21180620052...(a)news.east.earthlink.net>,
>
>
>
> Kofi <k...(a)anon.un> wrote:
> > An allele for autophagy is associated with autoimmune digestive
> > disorders. Butyrate is an HDAC inhibitor and uptake of butyrate can be
> > impaired in inflammatory gut injuries or via antibiotic usage as
> > friendly gut bacteria produce butyrate.
>
> > Biochem Biophys Res Commun. 2008 May 16;369(4):1179-83. Epub 2008 Mar 13.
>
> > Inhibition of histone deacetylase1 induces autophagy.
>
> > Oh M, Choi IK, Kwon HJ.
>
> > Chemical Genomics Laboratory, Department of Biotechnology, Yonsei
> > Biomedical Science and Technology Initiative, College of Life Science &
> > Biotechnology, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul
> > 120-749, Republic of Korea.
>
> > Autophagy is a process where cytoplasmic materials are degraded by
> > lysosomal machinery. Histone deacetylase (HDAC) inhibitors induce
> > autophagy, and HDAC6, one of class II HDAC isotypes, is directly
> > involved in autophagic degradation in the cell. However, it is unclear
> > if class I HDAC isotype such as HDCA1 is involved in this process. To
> > investigate if class I HDAC isotype is involved in autophagy, a specific
> > class I HDAC inhibitor and an siRNA of HDAC1 were used to treat HeLa
> > cells. Autophagic markers were then investigated. Both inhibition and
> > genetic knock-down of HDAC1 in the cells significantly induced
> > autophagic vacuole formation and lysosome function. Moreover, disruption
> > of HDAC1 leads to the conversion of LC3-I to LC3-II. Together, these
> > results demonstrate that HDAC1 could play a role in autophagy and
> > specific inhibition of HDAC1 can induce autophagy.
>
> > Publication Types:
> > * Research Support, Non-U.S. Gov't
>
> > PMID: 18342621
>
> Kofi,
>
> You take sodium butyrate right? Where do you get it?
>
> Thanks.
>
> Bob

Here: http://www.google.com/products?q=%22butyraid%22&sourceid=navclient-ff&ie=UTF-8&rlz=1B3GGGL_en__177US228&um=1
From: Kofi on 22 May 2008 19:19

> Kofi,
>
> You take sodium butyrate right? Where do you get it?
>
> Thanks.
>
> Bob

My doctor's office carries it. I've also gotten via Emerson Ecologics
online.
From: Bob Arnold on 22 May 2008 21:38
In article
<kofi-1A3555.18190722052008(a)earthlink.vsrv-sjc.supernews.net>,
Kofi <kofi(a)anon.un.org> wrote:

> > Kofi,
> >
> > You take sodium butyrate right? Where do you get it?
> >
> > Thanks.
> >
> > Bob
>
> My doctor's office carries it. I've also gotten via Emerson Ecologics
> online.

I'm impressed. I'd be surprised to find a doctor that's even heard of
it. All the doctors I've met only know about prescription drugs.

Bob
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