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From: ironjustice on 29 Jun 2008 17:48
"Iron overload with impaired glucose tolerance and diabetes"

CASE REPORT

Year : 2006 | Volume : 26 | Issue : 3 | Page : 129-130

Glucose intolerance due to pancreatic hemosiderosis in thalassemic
children

Nilesh Shewale, Prashant Patil
Department of Paediatric, Govt. Medical Collage and Hospital,
Aurangabad (M.S.), India


Correspondence Address:
Nilesh Shewale
Department of Paediatric, Dr. V.M. Govt. Medical College, Civil
Hospital, Solapur, (M.S.)
India


Source of Support: None, Conflict of Interest: None

Iron overload is commonly seen in thalassemia major patients because
of regular blood transfusions without iron chelation therapy (as is
case in developing countries).
Marked iron deposition has been found in liver, pancreas, thyroid,
parathyroid, adrenal zona glomerulosa, renal medulla, heart, bone
marrow and spleen which causes multiorgan dysfunction.
The association of chronic iron overload with impaired glucose
tolerance and diabetes is well recognized in thalassemics. Impaired
glucose tolerance precedes few months to five years before development
of diabetes.
We report glucose intolerance in thalassemia major children <12 years
old receiving blood transfusions without iron chelation.


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