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From: jay on 17 Sep 2008 14:45
Exposure to environmental pollutants may result in heartburns. By
hyperactivating cellular detox pathways in gut nerves, common foods
can evoke heartburns. Below abstract indicates that Omeprazole, a drug
for GERD, blocks the effect of BaP. BaP is created by combustion of
various matter including gasoline, diesel, cigarettes, garbage, etc.
It is one of many pollutants that activates cellular detoxification
pathways via Aryl Hydrocarbon Receptors. Many fruits, veggies, herbs,
spices, etc are also detoxed via same pathway.

Personally I have found that neither eating large meals, or eating
late, or even both cause me heartburn. Onions do. And onions also
aggravate the nerves in my arms. If you have heartburns, you might try
tracking down your trigger foods. Some common ones are: fatty foods,
onions, garlic, chili, tomatos, citrus, caffiene, chocolate, mint.

Omeprazole Alleviates Benzo[a]pyrene Cytotoxicity by Inhibition of
CYP1A1 Activity in Human and Mouse Hepatoma Cells.
Omeprazole is a drug used for treating gastro-oesophageal reflux
disease and duodenal ulcers. Omeprazole induces a xenobiotic-
metabolizing enzyme, cytochrome P450 1A1 (CYP1A1), as its ligand by
aryl hydrocarbon receptor (AhR) activation without binding. CYP1A1-
inducible chemicals, such as benzo[a]pyrene and 2,3,7,8-
tetrachlorodibenzo-p-dioxin, are known to have adverse effects (i.e.
carcinogenesis, mutagenesis and malformation). Unlike these typical
AhR activators, omeprazole has shown no experimental evidence of
carcinogenic activity. The possibility, however, remains that
omeprazole may aggravate the effect of environmental carcinogens
through CYP1A1 induction. We exposed benzo[a]pyrene and omeprazole
simultaneously to human and mouse hepatoma cells to investigate the
synergistic effect of these chemicals. Contrary to our prediction,
cytotoxicity of benzo[a]pyrene was inhibited by the omeprazole
exposure in a dose-dependent manner. Omeprazole did not alter CYP1A1
mRNA and protein levels induced by benzo[a]pyrene. The 7-ethoxy-
resorufin-O-deethylase assay revealed that omeprazole inhibited CYP1A1
enzyme activity. Kinetic analysis also demonstrated that it is a
competitive inhibitor for CYP1A1. The K(m) value of omeprazole against
CYP1A1 activity was 50.1 microM. We conclude that the effects of
omeprazole on CYP1A1 involve not only induction through AhR activation
but also inhibition of its enzyme activity, and that the protective
effect of omeprazole against benzo[a]pyrene cytotoxicity depends on
the latter. PMID: 18793272


For more info on Persistent Organic Pollutants, see
http://www.ejnet.org/dioxin/
http://www.ourstolenfuture.com/Basics/chemlist.htm
From: trigonometry1972 on 25 Sep 2008 09:05
On Sep 17, 11:45 am, jay <jaym1...(a)hotmail.com> wrote:
> Exposure to environmental pollutants may result in heartburns. By
> hyperactivating cellular detox pathways in gut nerves, common foods
> can evoke heartburns. Below abstract indicates that Omeprazole, a drug
> for GERD, blocks the effect of BaP. BaP is created by combustion of
> various matter including gasoline, diesel, cigarettes, garbage, etc.
> It is one of many pollutants that activates cellular detoxification
> pathways via Aryl Hydrocarbon Receptors. Many fruits, veggies, herbs,
> spices, etc are also detoxed via same pathway.
>
> Personally I have found that neither eating large meals, or eating
> late, or even both cause me heartburn. Onions do. And onions also
> aggravate the nerves in my arms. If you have heartburns, you might try
> tracking down your trigger foods. Some common ones are: fatty foods,
> onions, garlic, chili, tomatos, citrus, caffiene, chocolate, mint.

I avoid carbs and live on very fatty foods, chilies, onions, and even
tomatoes
and citrus and I am heartburn free. This is because I use a very
generous dose of betaine HCL capsules with my larger meals.
I do avoid chocolate, coffee, and tea but that is about all.
I will suggest carb rich foods mixed with fat used to be
on my No No list even back in the day when I was
a GERDie. I've seen wild long list of so-called trigger
foods compiled by fools following the defective standard
model of GERD. ( At least I believe it is a defective
explanation for the majority of GERD sufferers, IMO.




>
> Omeprazole Alleviates Benzo[a]pyrene Cytotoxicity by Inhibition of
> CYP1A1 Activity in Human and Mouse Hepatoma Cells.
> Omeprazole is a drug used for treating gastro-oesophageal reflux
> disease and duodenal ulcers. Omeprazole induces a xenobiotic-
> metabolizing enzyme, cytochrome P450 1A1 (CYP1A1), as its ligand by
> aryl hydrocarbon receptor (AhR) activation without binding. CYP1A1-
> inducible chemicals, such as benzo[a]pyrene and 2,3,7,8-
> tetrachlorodibenzo-p-dioxin, are known to have adverse effects (i.e.
> carcinogenesis, mutagenesis and malformation). Unlike these typical
> AhR activators, omeprazole has shown no experimental evidence of
> carcinogenic activity. The possibility, however, remains that
> omeprazole may aggravate the effect of environmental carcinogens
> through CYP1A1 induction. We exposed benzo[a]pyrene and omeprazole
> simultaneously to human and mouse hepatoma cells to investigate the
> synergistic effect of these chemicals. Contrary to our prediction,
> cytotoxicity of benzo[a]pyrene was inhibited by the omeprazole
> exposure in a dose-dependent manner. Omeprazole did not alter CYP1A1
> mRNA and protein levels induced by benzo[a]pyrene. The 7-ethoxy-
> resorufin-O-deethylase assay revealed that omeprazole inhibited CYP1A1
> enzyme activity. Kinetic analysis also demonstrated that it is a
> competitive inhibitor for CYP1A1. The K(m) value of omeprazole against
> CYP1A1 activity was 50.1 microM. We conclude that the effects of
> omeprazole on CYP1A1 involve not only induction through AhR activation
> but also inhibition of its enzyme activity, and that the protective
> effect of omeprazole against benzo[a]pyrene cytotoxicity depends on
> the latter. PMID: 18793272
>
> For more info on Persistent Organic Pollutants, seehttp://www.ejnet.org/dioxin/http://www.ourstolenfuture.com/Basics/chemlist.htm

It is better to avoid benzopyrene and other polycyclic aromatic
hydrocarbons i.e. ham, smoked foods, grilled foods, hard
fried foods, foods blacken or browned due to heat.

PPI meds have risks all on their own. They may do about as much
to cause esophageal cancer in balance what they do to prevent it.
Indeed they may on balance increase the risk.
I'll suggest these meds may increase the risks of skin cancer,
free radical damage, and neurological damage over the
long term.

Plus the PPI meds are endocrine disruptor which ironic given
the use of the ourstolenfuture website.
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