Fruits
in [Fibromyalgia]
|
From: ironjustice on 22 Jun 2008 01:07 "Fruit extract was comparable with glibenclamide" JOURNAL OF HEALTH SCIENCE Vol. 52 (2006) , No. 3 283-291 Anti-Diabetic Activity of Fruits of Terminalia chebula on Streptozotocin Induced Diabetic Rats Gandhipuram Periasamy Senthil Kumar1), Palanisamy Arulselvan1), Durairaj Sathish Kumar1) and Sorimuthu Pillai Subramanian1) 1) Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus (Received February 10, 2006) (Accepted March 21, 2006) The present study was aimed to evaluate the anti-diabetic potential of Terminalia chebula (T. chebula) fruits on streptozotocin (STZ)-induced experimental diabetes in rats. Oral administration of ethanolic extract of the fruits (200 mg/kg body weight/rat/day) for 30 days significantly reduced the levels of blood glucose and glycosylated hemoglobin in diabetic rats. Determination of plasma insulin levels revealed the insulin stimulating action of the fruit extract. Also, the alterations observed in the activities of carbohydrate and glycogen metabolising enzymes were reverted back to near normal after 30 days of treatment with the extract. Electron microscopic studies showed significant morphological changes in the mitochondria and endoplasmic reticulum of pancreatic â cells of STZ-induced diabetic rats. Also, a decrease in the number of secretory granules of â-cells was observed in the STZ-induced diabetic rats and a these pathological abnormalities were normalized after treatment with T. chebula extract. The efficacy of the fruit extract was comparable with glibenclamide, a well known hypoglycemic drug. Key words diabetes, Terminalia chebula, ethanolic extract, carbohydrate metabolism, electron microscope Gandhipuram Periasamy Senthil Kumar, Palanisamy Arulselvan, Durairaj Sathish Kumar and Sorimuthu Pillai Subramanian; "Anti-Diabetic Activity of Fruits of Terminalia chebula on Streptozotocin Induced Diabetic Rats", J. Health Sci., Vol. 52, pp.283-291 (2006) . doi:10.1248/jhs.52.283 JOI JST.JSTAGE/jhs/52.283 Copyright (c) 2006 by The Pharmaceutical Society of Japan -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
|
Pages: 1 Prev: Diabetic Deafness Next: HGH Growth Hormone used by today's Athletes |