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From: lian on 31 Oct 2005 14:49
first forget my bad english, cause it's not my language (I am from
Israel).


I got convinced by the logic to avoid EFA in order to decrease
inflammation. And I do follow it actually for the last 2 months.

But I keep worry maybe I risk myself. Espcially I am concerning the
state of my brain cause I am prone to depression. Lately I read 2 thing
that again raised this worry.

1. endocannabiod (anandamide) are neuroprotective. They are
synthesized from arachidonic acid (anandamide=amide bond +arachidonic
acid).
They are actually 2-arachidonoyl glycerol.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15729296&query_hl=16

and more (Pubmed search for: "Shohami e"+ arachidonic)

In this link,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15730585&query_hl=16

they found that if you block inflammatory arachidonic acid metabolites
(by COX-2 inhibitors), there is divergence of arachidonic acid from
the harmful inflammatory metabolites to synthesize endocannabiods.

MY QUESTIONS TO YOU:
A. If I avoid dietary arachidonic acid, will I have too little
endocannabiods?
B. I f I want to be "on the safe side", should I consume dietary
arachidonic acid, given it will be from the best source? (most
un-processed, stable, un-oxidated source)?
Given that I'm not going to take any COX-2 inhibitor?


2. and the second thing is this link. again I'm worried I am risking my
already problematic brain.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16226347&query_hl=4

From: james.esquivel on 31 Oct 2005 15:56
Hello Lian,

Here is a good website which can help you with your questions
concerning DHA/EPA:
http://www.zonenetonline.com/ZoneNetOnline/(frsro3vytkqxhomebetogojx)/Products/FishOil/fishoil_detail.aspx?Ath=False&realname=10083788&hdr=&ProductID=600005&cat=0

Thanks.

James



lian wrote:
> first forget my bad english, cause it's not my language (I am from
> Israel).
>
>
> I got convinced by the logic to avoid EFA in order to decrease
> inflammation. And I do follow it actually for the last 2 months.
>
> But I keep worry maybe I risk myself. Espcially I am concerning the
> state of my brain cause I am prone to depression. Lately I read 2 thing
> that again raised this worry.
>
> 1. endocannabiod (anandamide) are neuroprotective. They are
> synthesized from arachidonic acid (anandamide=amide bond +arachidonic
> acid).
> They are actually 2-arachidonoyl glycerol.
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15729296&query_hl=16
>
> and more (Pubmed search for: "Shohami e"+ arachidonic)
>
> In this link,
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15730585&query_hl=16
>
> they found that if you block inflammatory arachidonic acid metabolites
> (by COX-2 inhibitors), there is divergence of arachidonic acid from
> the harmful inflammatory metabolites to synthesize endocannabiods.
>
> MY QUESTIONS TO YOU:
> A. If I avoid dietary arachidonic acid, will I have too little
> endocannabiods?
> B. I f I want to be "on the safe side", should I consume dietary
> arachidonic acid, given it will be from the best source? (most
> un-processed, stable, un-oxidated source)?
> Given that I'm not going to take any COX-2 inhibitor?
>
>
> 2. and the second thing is this link. again I'm worried I am risking my
> already problematic brain.
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16226347&query_hl=4

From: james.esquivel on 31 Oct 2005 15:57
Sorry! I sent you the wrong link. Here is the corrected link:
http://www.zonenetonline.com/ZoneNetOnline/Products/FishOil/fishoil_detail.aspx?Ath=False&realname=10083788&hdr=&ProductID=600005&cat=0

Let me know if you have questions.

James

From: montygram on 31 Oct 2005 16:30
You can get some lithium orotate over the internet until you clear the
arachidonic acid out of your body. What you probably suffer from is a
form of arachidonate cascade mania, so eating more beef, for example,
would be the worst thing you could do. It takes more than 2 months -
more like 2 years, to clear it out. Everything AA does the Mead acid
does in a more attentuated, less dangerous way, but the Mead acid won't
replace the AA overnight. You may feel a bit strange in the meantime,
so I can't advise you on what to do about that. In my case, I felt a
strange sensation in my lungs, or it may have been that I was breathing
deeper, which most likely had to do with saturated fatty acids
replacing unsaturated ones in lung surfactant. Mary Enig has written
about the "essentiality" of certain saturated fatty acids in lung
surfactant, so I'm guessing that's what it was. You may also notice a
weird body odor, which seems to have to do with the replacement of the
unsaturated fatty acids, which have a rancid smell, due to lipid
peroxidation. Other than that, I noticed an ability to really focus
and concentrate mentally, and a more methodical way of doing things.
I've been doing this for about 4 years now, and biochemist Ray Peat has
avoided any major unsaturated fat source for probably around double
that, so if there's something to worry about, we would have experienced
it. However, you still must eat high quality protein, avoid food high
in iron (at least for the next couple of years) and beverages with
substances that disrupt your body's metabolism (stick to tea, coffee,
club soda, or tropical fruit juices with no additives), etc. Calcium
and magnesium citrate and vitamin D are good supplements to take. Stay
away from multi-vitamins, but a little nutritional yeast with each meal
(half a teaspoon or so) is a good idea.

Keep us posted on what happens.

From: lian on 31 Oct 2005 17:43
thanks for the replies.

Sbharris, you wrote "You're not going to make them without some w-6
somewhere"
and Monty wrote "Everything AA does the Mead acid does in a more
attentuated, less dangerous way".
Do you think Monty is right, so I can count on the Mead acid to create
2-arachidonoyl glycerol and anandamide ? I wish this is the case, but
how can I know?

I would like to avoid W-6, cause I really want to decrease
inflammation.
But I am afraid to be guinea pig, and afterward to find out I don't
have all kind of good arachidonic metabolites.
But on the other hand, maybe the COX-2 experiments shows , that if you
DON'T take cox-2 inhibitor, the default of AA is to became inflammatory
and NOT cannabinoid?


I don't what to do. sholud I avoid beef or not?
Should I eat w-6 (of course not processed/refined), like in fresh
nuts?

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