Evidence of Hemolysis In Lupus
in [Lupus]
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From: ironjustice on 19 Jul 2008 13:20 In lupus they have .. "no idea" .. what .. causes it. They have .. theories. All the markers the medical profession use to assess the overall picture of a person with lupus points to the fact they HAVE iron **overload**. That is using .. science .. reason .. logic. Iron IN the skin sooo .. MUCH they are targeting the iron SPECIFICALLY in lupus patients with "new sunscreen containing iron binders." First .. ferritin .. is an iron storage compartment. It is raised in EVERYONE with lupus / hyperferritinemia. Lupus is CLOSELY linked to two different diseases so far established and **accepted**. Thalassemia and Sickle Cell anemia. Sickle Cell anemia and Thalassemia are iron LOADING diseases. They are what is called Hemolytic / hemolysis .. anemias. Hemolysis is the breaking down of a red blood cell. They have low red blood cells / broken cells. NOT no iron .. just no .. red .. blood .. cells. The red blood cells .. lysis / break down / hemolysis. Hence .. hemo-lysis. .. The doctors looks at a person with lupus and says "you are .. iron deficient" .. because .. ? They have "low red blood cells" . When in FACT .. all .. the markers ACCEPTED by .. **reasonable** .. men .. sayyyy .. ? They are iron overloaded and ARE experiencing **hemolysis** JUST like sickle and thalassemia. Creatine kinase .. "signof hemolysis raised" .. Ferritin .. "marker of iron stores really high" .. D-dimer "mark of hemolysis in thrombosis found in high amounts" .. Urate dehydrogenase "sign of red blood cell hemolysis raised " Porphyrins "mark of hemolysis raised" Erythropoietin "erythropoietin is either normal or low in a state of iron sufficiency. It is normal" Fatigue .. debilitating .. fatigue .. PROVEN to be CAUSED by **hemolysis** and experienced by everyone with lupus. All diseases .. so far .. that HAVE been linked to lupus are iron loading .. NOW .. porphyria cutanea tarda. "Photosensitivity" But .. not .. lupus . Porphyrins come from a destroyed red blood cell. And .. their 'take' .. "75% of people with lupus are iron DEFICIENT" .. The number one and two treatments are the very treatments they use for increased red blood cell production in iron overload. Cyclophosphamide / phebotomy the preferred alternative and radioactive- phosphorus which was REPLACED by phebotomy because of the deaths caused by radioactive-phosphorus. The odds .. odds .. say .. there is something wrong in Denmark WHEN .. all the diseases associated with lupus are iron overloaded and LUPUS .. "everyone is iron deficient." Just something to .. wonder about .. in the world of .. "paradoxes" .. Yeah .. right .. Target the hemolysis .. "which isn't there" .. Vitamin E deficiency causes hemolysis. Hemolyis is now being treated with tocopherol.. Phlebotomy / iron reduction .. "just so happens to coincidentally" .. remove lesions in the centre of the face. Phlebotomy / iron reduction is the treatment for EVERY disease associated to lupus and it has never been tested in lupus .. because everyone is .. anemic. Anemic .. "Low red blood cells" .. but NO .. "iron deficiency" .. using **reason**. Anyone want to .. bet .. ? Oh yeah .. somebody already .. did .. I wonder how the sales are going for the "iron binding sunscreen targeting lupus patients".. ? Anyone .. invest .. ? http://tinyurl.com/5zelvp Photoprotective Iron Chelator Technology "The trials initially will focus on individuals with the autoimmune disease lupus, who are extremely sensitive to the sun." http://www.sciencedaily.com/releases/2006/09/060910143024.htm Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
From: ironjustice on 19 Jul 2008 13:57 On Jul 19, 10:20 am, "ironjust...(a)aol.com" <ironjust...(a)aol.com> wrote: hemolytic anemia << I guess it is well KNOWN .. hemolysis DOES .. happen in Lupus JUST like sickle cell. http://www.itzarion.com/lupusanemia.html If this were a .. drug. "Striking decrease of hospitalization days" "Viscosity" Arch Pediatr 2000 Mar;7(3):249-55 [Prevention of sickle cell crises with multiple phlebotomies]. Bouchair N, Manigne P, Kanfer A, Raphalen P, de Montalembert M, Hagege I, Verschuur A, Maier-Redelsperger M, Girot R Service de pediatrie, CHU, Constantine, Algerie. OBJECTIVES: Sickle cell disease patients suffering from frequent painful crises were submitted to phlebotomies in order to reduce hospitalization days due to pain, through hemoglobin (Hb) level reduction and iron deficiency in patients with an hemoglobin level equal to or above 9.5 g/dL. PATIENTS: Seven sickle cell disease patients (four SC, three SS), aged four to 24 years, were submitted to sequential phlebotomies during periods from 18 months to four years. METHODS: The number of hospitalization days for crises was considered. The volumes and frequencies of phlebotomies were adjusted according to the patients ages, the hemoglobin concentrations and the serum ferritin levels. RESULTS: One hundred and forty-four hospitalization days were recorded in the seven patients in the year preceding the treatment. During the study period, the annual numbers of hospitalization days were respectively 20, five, six and one. Mean hemoglobin concentration was 10.7 g/dL before phlebotomies and 8.8 to 9.2 g/dL during the four years of treatment. Mean corpuscular volume, mean corpuscular hemoglobin concentration and serum ferritin were also reduced. The volume of phlebotomies was 116 to 39 mL/kg/year according to the patients. COMMENTS AND CONCLUSION: The striking decrease of the number of hospitalization days for all the patients suggests a closed relationship between therapy and clinical improvement. The mechanism of this effect is probably multifactorial: a) the concentration of Hb level is known to influence the blood viscosity and its decrease always improved rheology in sickle cell disease patients; b) the mean corpuscular hemoglobin concentration is a critical factor concerning the HbS molecule polymerization in sickle cell disease, and its slight reduction may have an important biological effect. We observed these two biological modifications in our patients and suggest that they mediate the clinical effects. The iron deficiency induced by phlebotomies has no evident deleterious consequence either on height and weight in the children or on intellectual performance in any patients. PMID: 10761600, UI: 20224666 ---------------------- "Hb of 5.5 g/dl be used as an indication for transfusion" Annals of Clinical and Laboratory Science, Vol 24, Issue 5, 396-400 Copyright © 1994 by Association of Clinical Scientists -------------------------------------------------------------------------------- Articles When to transfuse blood in sickle cell disease? Lessons from Jehovah's Witnesses ES Pearlman and SK Ballas Hemoglobin concentration of 7 to 8 g/dl has been considered an indication for transfusion in the general adult population and has also been frequently applied to patients with sickle cell disease (SCD). Through a review of the case histories of two patients with SCD who were also Jehovah's Witnesses and developed severe anemia, and considering as well the clinical characteristics of this population and the basic physiology of oxygen transport, the appropriateness is questioned of this transfusion "trigger" in patients with SCD. It is suggested for the latter that a Hb of 5.5 g/dl be used as an indication for transfusion except in very specific clinical circumstances. Copyright © 1994 by the Association of Clinical Scientists. --------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > In lupus they have .. "no idea" .. what .. causes it. > > They have .. theories. > > All the markers the medical profession use to assess the overall > picture of a person with lupus points to the fact they HAVE iron > **overload**. > > That is using .. science .. reason .. logic. > > Iron IN the skin sooo .. MUCH they are targeting the iron SPECIFICALLY > in lupus patients with "new sunscreen containing iron binders." > > First .. ferritin .. is an iron storage compartment. > It is raised in EVERYONE with lupus / hyperferritinemia. > Lupus is CLOSELY linked to two different diseases so far established > and **accepted**. > Thalassemia and Sickle Cell anemia. > Sickle Cell anemia and Thalassemia are iron LOADING diseases. > They are what is called Hemolytic / hemolysis .. anemias. > Hemolysis is the breaking down of a red blood cell. > They have low red blood cells / broken cells. > NOT no iron .. just no .. red .. blood .. cells. > The red blood cells .. lysis / break down / hemolysis. > > Hence .. hemo-lysis. > . > The doctors looks at a person with lupus and says "you are .. iron > deficient" .. because .. ? > They have "low red blood cells" . > When in FACT .. all .. the markers ACCEPTED by .. **reasonable** .. > men .. sayyyy .. ? > > They are iron overloaded and ARE experiencing **hemolysis** JUST like > sickle and thalassemia. > > Creatine kinase .. > "signof hemolysis raised" .. > Ferritin .. > "marker of iron stores really high" .. > D-dimer > "mark of hemolysis in thrombosis found in high amounts" .. > Urate dehydrogenase > "sign of red blood cell hemolysis raised " > Porphyrins > "mark of hemolysis raised" > Erythropoietin > "erythropoietin is either normal or low in a state of iron > sufficiency. It is normal" > > Fatigue .. debilitating .. fatigue .. PROVEN to be CAUSED by > **hemolysis** and experienced by everyone with lupus. > > All diseases .. so far .. that HAVE been linked to lupus are iron > loading .. NOW .. porphyria cutanea tarda. > > "Photosensitivity" > > But .. not .. lupus . > > Porphyrins come from a destroyed red blood cell. > > And .. their 'take' .. > "75% of people with lupus are iron DEFICIENT" .. > > The number one and two treatments are the very treatments they use for > increased red blood cell production in iron overload. > Cyclophosphamide / phebotomy the preferred alternative and radioactive- > phosphorus which was REPLACED by phebotomy because of the deaths > caused by radioactive-phosphorus. > > The odds .. odds .. say .. there is something wrong in Denmark WHEN .. > all the diseases associated with lupus are iron overloaded and > LUPUS .. "everyone is iron deficient." > > Just something to .. wonder about .. in the world of .. "paradoxes" .. > > Yeah .. right .. > > Target the hemolysis .. "which isn't there" .. > > Vitamin E deficiency causes hemolysis. > Hemolyis is now being treated with tocopherol.. > > Phlebotomy / iron reduction .. "just so happens to coincidentally" .. > remove lesions in the centre of the face. > > Phlebotomy / iron reduction is the treatment for EVERY disease > associated to lupus and it has never been tested in lupus .. because > everyone is .. anemic. > > Anemic .. > > "Low red blood cells" .. but NO .. "iron deficiency" .. using > **reason**. > > Anyone want to .. bet .. ? > > Oh yeah .. somebody already .. did .. > > I wonder how the sales are going for the "iron binding sunscreen > targeting lupus patients".. ? > > Anyone .. invest .. ? > > http://tinyurl.com/5zelvp > > Photoprotective Iron Chelator Technology > > "The trials initially will focus on individuals with the > autoimmune disease lupus, who are extremely sensitive to the sun." > > http://www.sciencedaily.com/releases/2006/09/060910143024.htm > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
From: ferrous on 19 Jul 2008 20:03 "Thalassemia and Sickle Cell anemia. Sickle Cell anemia and Thalassemia are iron LOADING diseases." Nope, they are genetic disorders which are mutations to a specific disease. What is that disease? How can it provide relief from that disease? How do they relate geographically to that disease? Them thar questions ain't gonna go away. "All the markers the medical profession use to assess the overall picture of a person with lupus points to the fact they HAVE iron **overload**. That is using .. science .. reason .. logic." Nope, here is the definitions of various forms oflupis: * Systemic lupus erythematosus (SLE), commonly known as "Lupus". When the term 'lupus' is used without modification, it usually means SLE, especially in a medical context. + Drug-induced lupus erythematosus, a drug-induced form of SLE + Lupus nephritis, an inflammation of the kidneys caused by SLE, when anti-DNA antibodies, which the body makes, precipitate in the kidneys. * Lupus pernio, a feature of sarcoidosis. * Lupus vulgaris, a feature of cutaneous tuberculosis * Lupus anticoagulant, an antibody causing a delay in coagulation Jesus ate a mediterranean diet.
From: ironjustice on 19 Jul 2008 22:16 On Jul 19, 10:20 am, "ironjust...(a)aol.com" <ironjust...(a)aol.com> wrote: Urate dehydrogenase "sign of red blood cell hemolysis raised " << Whoops .. Lactic acid dehydrogenase .. NOT urate dehydrogenase .. "Serum LDH is a criterion for hemolysis. LDH is not specific because it is ubiquitous and can be released from the neoplastic cells of the liver or other damaged organs. Although an increase in LDH isozyme 1 and 2 is more specific for RBC destruction, these enzymes are also increased in patients with myocardial infarction." Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > In lupus they have .. "no idea" .. what .. causes it. > > They have .. theories. > > All the markers the medical profession use to assess the overall > picture of a person with lupus points to the fact they HAVE iron > **overload**. > > That is using .. science .. reason .. logic. > > Iron IN the skin sooo .. MUCH they are targeting the iron SPECIFICALLY > in lupus patients with "new sunscreen containing iron binders." > > First .. ferritin .. is an iron storage compartment. > It is raised in EVERYONE with lupus / hyperferritinemia. > Lupus is CLOSELY linked to two different diseases so far established > and **accepted**. > Thalassemia and Sickle Cell anemia. > Sickle Cell anemia and Thalassemia are iron LOADING diseases. > They are what is called Hemolytic / hemolysis .. anemias. > Hemolysis is the breaking down of a red blood cell. > They have low red blood cells / broken cells. > NOT no iron .. just no .. red .. blood .. cells. > The red blood cells .. lysis / break down / hemolysis. > > Hence .. hemo-lysis. > . > The doctors looks at a person with lupus and says "you are .. iron > deficient" .. because .. ? > They have "low red blood cells" . > When in FACT .. all .. the markers ACCEPTED by .. **reasonable** .. > men .. sayyyy .. ? > > They are iron overloaded and ARE experiencing **hemolysis** JUST like > sickle and thalassemia. > > Creatine kinase .. > "signof hemolysis raised" .. > Ferritin .. > "marker of iron stores really high" .. > D-dimer > "mark of hemolysis in thrombosis found in high amounts" .. > Urate dehydrogenase > "sign of red blood cell hemolysis raised " > Porphyrins > "mark of hemolysis raised" > Erythropoietin > "erythropoietin is either normal or low in a state of iron > sufficiency. It is normal" > > Fatigue .. debilitating .. fatigue .. PROVEN to be CAUSED by > **hemolysis** and experienced by everyone with lupus. > > All diseases .. so far .. that HAVE been linked to lupus are iron > loading .. NOW .. porphyria cutanea tarda. > > "Photosensitivity" > > But .. not .. lupus . > > Porphyrins come from a destroyed red blood cell. > > And .. their 'take' .. > "75% of people with lupus are iron DEFICIENT" .. > > The number one and two treatments are the very treatments they use for > increased red blood cell production in iron overload. > Cyclophosphamide / phebotomy the preferred alternative and radioactive- > phosphorus which was REPLACED by phebotomy because of the deaths > caused by radioactive-phosphorus. > > The odds .. odds .. say .. there is something wrong in Denmark WHEN .. > all the diseases associated with lupus are iron overloaded and > LUPUS .. "everyone is iron deficient." > > Just something to .. wonder about .. in the world of .. "paradoxes" .. > > Yeah .. right .. > > Target the hemolysis .. "which isn't there" .. > > Vitamin E deficiency causes hemolysis. > Hemolyis is now being treated with tocopherol.. > > Phlebotomy / iron reduction .. "just so happens to coincidentally" .. > remove lesions in the centre of the face. > > Phlebotomy / iron reduction is the treatment for EVERY disease > associated to lupus and it has never been tested in lupus .. because > everyone is .. anemic. > > Anemic .. > > "Low red blood cells" .. but NO .. "iron deficiency" .. using > **reason**. > > Anyone want to .. bet .. ? > > Oh yeah .. somebody already .. did .. > > I wonder how the sales are going for the "iron binding sunscreen > targeting lupus patients".. ? > > Anyone .. invest .. ? > > http://tinyurl.com/5zelvp > > Photoprotective Iron Chelator Technology > > "The trials initially will focus on individuals with the > autoimmune disease lupus, who are extremely sensitive to the sun." > > http://www.sciencedaily.com/releases/2006/09/060910143024.htm > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
From: ironjustice on 7 Aug 2008 14:13
On Jul 19, 10:20 am, "ironjust...(a)aol.com" <ironjust...(a)aol.com> wrote:"ironbinding sunscreen targeting lupus patients".. << "UVA-induced necrotic cell death reflects the intracellular level of LIP (iron) " J Invest Dermatol. 2004 Oct;123(4):771-80. Related Articles, Links Susceptibility of Skin Cells to UVA-induced Necrotic Cell Death Reflects the Intracellular Level of Labile Iron. Zhong JL, Yiakouvaki A, Holley P, Tyrrell RM, Pourzand C. Department of Pharmacy and Pharmacology, University of Bath, Bath, UK. The mechanism of resistance of keratinocytes to ultraviolet A (UVA) (320-400 nm)-induced oxidative damage has not yet been elucidated. Here, we examined the possible link between the intracellular level of the labile iron pool (LIP) and the susceptibility to UVA-induced cell death using a series of human skin fibroblast and keratinocyte cell lines as a model. Resistance of keratinocytes to UVA-induced cell death was confirmed by flow cytometry and in fibroblasts necrosis was found to be the primary mode of cell death induced by UVA. The percentage of necrosis in fibroblasts also correlated with the extent of intracellular ATP depletion, a hallmark of necrotic cell death. The evaluation of the intracellular level of LIP by calcein assay revealed that both "basal" and "UVA-induced" levels of LIP in keratinocytes were several fold lower than in fibroblasts. Accordingly the dose to give an equivalent level of necrosis was several fold lower in fibroblasts than in keratinocytes. Furthermore, the modulation of "basal" or "UVA-induced" level of LIP by either Desferal and/or hemin treatment significantly affected the extent of UVA-induced necrotic cell death and ATP depletion in all the cell lines. Cellular susceptibility to UVA-induced necrotic cell death appears to reflect the intracellular level of LIP. PMID: 15373784 [PubMed - in process] --------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > In lupus they have .. "no idea" .. what .. causes it. > > They have .. theories. > > All the markers the medical profession use to assess the overall > picture of a person with lupus points to the fact they HAVEiron > **overload**. > > That is using .. science .. reason .. logic. > > IronIN the skin sooo .. MUCH they are targeting theironSPECIFICALLY > in lupus patients with "new sunscreen containingironbinders." > > First .. ferritin .. is anironstorage compartment. > It is raised in EVERYONE with lupus / hyperferritinemia. > Lupus is CLOSELY linked to two different diseases so far established > and **accepted**. > Thalassemia and Sickle Cell anemia. > Sickle Cell anemia and Thalassemia areironLOADING diseases. > They are what is called Hemolytic / hemolysis .. anemias. > Hemolysis is the breaking down of a red blood cell. > They have low red blood cells / broken cells. > NOT noiron.. just no .. red .. blood .. cells. > The red blood cells .. lysis / break down / hemolysis. > > Hence .. hemo-lysis. > . > The doctors looks at a person with lupus and says "you are ..iron > deficient" .. because .. ? > They have "low red blood cells" . > When in FACT .. all .. the markers ACCEPTED by .. **reasonable** .. > men .. sayyyy .. ? > > They areironoverloaded and ARE experiencing **hemolysis** JUST like > sickle and thalassemia. > > Creatine kinase .. > "signof hemolysis raised" .. > Ferritin .. > "marker ofironstores really high" .. > D-dimer > "mark of hemolysis in thrombosis found in high amounts" .. > Urate dehydrogenase > "sign of red blood cell hemolysis raised " > Porphyrins > "mark of hemolysis raised" > Erythropoietin > "erythropoietin is either normal or low in a state ofiron > sufficiency. It is normal" > > Fatigue .. debilitating .. fatigue .. PROVEN to be CAUSED by > **hemolysis** and experienced by everyone with lupus. > > All diseases .. so far .. that HAVE been linked to lupus areiron > loading .. NOW .. porphyria cutanea tarda. > > "Photosensitivity" > > But .. not .. lupus . > > Porphyrins come from a destroyed red blood cell. > > And .. their 'take' .. > "75% of people with lupus areironDEFICIENT" .. > > The number one and two treatments are the very treatments they use for > increased red blood cell production inironoverload. > Cyclophosphamide / phebotomy the preferred alternative and radioactive- > phosphorus which was REPLACED by phebotomy because of the deaths > caused by radioactive-phosphorus. > > The odds .. odds .. say .. there is something wrong in Denmark WHEN .. > all the diseases associated with lupus areironoverloaded and > LUPUS .. "everyone isirondeficient." > > Just something to .. wonder about .. in the world of .. "paradoxes" .. > > Yeah .. right .. > > Target the hemolysis .. "which isn't there" .. > > Vitamin E deficiency causes hemolysis. > Hemolyis is now being treated with tocopherol.. > > Phlebotomy /ironreduction .. "just so happens to coincidentally" .. > remove lesions in the centre of the face. > > Phlebotomy /ironreduction is the treatment for EVERY disease > associated to lupus and it has never been tested in lupus .. because > everyone is .. anemic. > > Anemic .. > > "Low red blood cells" .. but NO .. "irondeficiency" .. using > **reason**. > > Anyone want to .. bet .. ? > > Oh yeah .. somebody already .. did .. > > I wonder how the sales are going for the "ironbinding sunscreen > targeting lupus patients".. ? > > Anyone .. invest .. ? > > http://tinyurl.com/5zelvp > > PhotoprotectiveIronChelator Technology > > "The trials initially will focus on individuals with the > autoimmune disease lupus, who are extremely sensitive to the sun." > > http://www.sciencedaily.com/releases/2006/09/060910143024.htm > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk |