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The role of A20 in preventing colitis
<http://www.sciencedaily.com/releases/2010/07/100705081202.htm> First Step to New Therapy for Chronic Bowel Disease ScienceDaily (Aug. 5, 2010) � Scientists associated with VIB (Flanders Institute for Biotechnology) and Ghent University (UGent) have discovered that A20 protein plays an important protective ro... 9 Aug 2010 02:32
Clotting is a part of the innate immune system
Compare this with my previous posts on heparin and heparanase in Crohn's. <http://www.sciencedaily.com/releases/2010/08/100803101920.htm> Fighting Infections With Blood Clots ScienceDaily (Aug. 4, 2010) � A research team at Ludwig-Maximilians-Universitaet in Munich has shown that clot formation within smal... 8 Aug 2010 23:18
Join us in chat! Ostomyland 24/7 Support - Main Meeting Saturday 7th August
Have you been told you need an ostomy (colostomy/ileostomy) to deal with your Crohn's or Ulcerative Colitis? Maybe you have already had this surgery and are coping with it? Or maybe a loved one is dealing with this and you want to support them? We are an ostomy support group, here to help you with both the prac... 7 Aug 2010 14:46
HIF-1alpha might treat Parkinson's
J Neurochem. 2010 Jul 23 � HIF Prolyl Hydroxylase Inhibition Increases Cell viability and Potentiates Dopamine Release in Dopaminergic Cells. Leander Johansen J, Nikolaj Sager T, Lotharius J, Witten L, Mork A, Egebjerg J, Thirstrup K. Discovery Biology Research, H. Lundbeck A/S, Valby, Denmark. Abstract Hypo... 6 Aug 2010 12:42
prolyl hydroxylase 1 inhibition improves colitis
PHD1 inhibition boosts HIF-1alpha which then boosts cathelicidin synthesis. Iron lowers HIF-1alpha which might explain why iron in drinking water is associated with colitis. Curiously, cobalt also boosts HIF-1alpha and methylcobalamin (methyl-B12) is rich in cobalt. This might tie B12 deficiency together w... 6 Aug 2010 06:05
Glutamine production is knocked out in some IBD
This may finally explain why glutamine and alpha ketoglutarate have been beneficial for patients with inflammatory bowel conditions. http://www.sciencedaily.com/releases/2010/08/100802110825.htm Scientists Target Possible Cause of One Form of Bowel Disease ScienceDaily (Aug. 2, 2010) � A possible cause of ir... 6 Aug 2010 03:55
Research: Studies offer encouraging data on preventing Crohn's disease recurrence
http://www.eurekalert.org/pub_releases/2010-08/aga-soe080510.php Studies offer encouraging data on preventing Crohn's disease recurrence Biological agents may play an important role in maintaining remission in Crohn's disease, according to two new studies in Clinical Gastroenterology and Hepatology, the offici... 9 Aug 2010 15:42
TB infection of macrophages via eicosanoids
Knocking out PGE2 might serve to limit the function of Tregs, which would help explain why colitis involves not just defective macrophage (innate) response but also an autoantibody problem. http://www.sciencedaily.com/releases/2010/07/100729101603.htm Tuberculosis Advance: Existing Drugs Can Potentially Targe... 5 Aug 2010 22:30
Requesting help tracking down a recent paper on viral infection and DNA repair
There was a recent article describing how a cell deliberately introduces errors into its own DNA to subtly resist viral infection. Somehow sabotaging its own DNA with "noise" renders the cells more resistant to attack. I think it was published in the last couple of months but multiple searches haven't turned ... 2 Aug 2010 02:46
Calcium release via IP3 regulates autophagy
In light of the recent work on VDR agonist lithocholic acid and the lifespan regulation of klotho, this work on calcium is all-the-more interesting. IP3 overactivity would appear to be a weak link when dealing with misfolded proteins as seen in Parkinson's. <http://www.sciencedaily.com/releases/2010/07/100727... 1 Aug 2010 01:57
Heparin improves some bedridden patients
Part of cathelicidin's antiviral effects against CMV are mediated via its affinity for heparan sulfate. It's possible the heparin in this study is interfering with the ability of viruses like CMV to infect cells. Heparin is also neuroprotective [PMID 19953344]. Heparin is also effective against UC [PMID 1704... 30 Jul 2010 03:13
Anti-inflammatory Nicotine
Do you have literature linking lithium to cholinergic function? You seem to imply the two are intertwined (and I'm inclined to agree). ----------------------- Lecithin is recommended as a BETTER method of choline supplementation due to its ability to produce a 5 times increase of choline and a rete... 30 Jul 2010 01:03
NGF impairs amyloid production
Cell Death Differ. 2010 Jul;17(7):1126-33. Epub 2010 Apr 16. � Does the term 'trophic' actually mean anti-amyloidogenic? The case of NGF. Calissano P, Amadoro G, Matrone C, Ciafre S, Marolda R, Corsetti V, Ciotti MT, Mercanti D, Di Luzio A, Severini C, Provenzano C, Canu N. Institute of Neurobiology and Mole... 26 Jul 2010 21:37
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