Colchicine and Vitamin E and Inflammation
in [Lupus]
|
From: ironjustice on 4 Dec 2007 19:25 This colchicine is so good but it kills you but people still / HAVE .. to take it. Any ideas .. why .. ? "Protein oxidation and lipid peroxidation" Methods Find Exp Clin Pharmacol. 2007 Oct;29(8):521-4. Links Changes in serum carbonyl and malondialdehyde levels following colchicine and vitamin E treatment in Behcet's disease. Gulbahar O, Adisen H, Koca C, Aricioglu A, Gulekon A. Department of Medical Biochemistry, Faculty of Medicine, Fatih University, Ankara, Turkey. mdzengin(a)yahoo.com. Behcet's disease (BD) is an inflammatory disorder of an unknown cause, but growing evidence indicates that the oxidative stress is increased in BD, owing to the overproduction of reactive oxygen species (ROS) and decreased efficiency of antioxidant defenses. ROS affect proteins and lipids and cause their oxidation, therefore, contributing to the formation of oxidation products: carbonyl, a marker of protein oxidation, and malondialdehyde (MDA), a marker of lipid peroxidation. The investigation was undertaken to evaluate protein oxidation (carbonyl group) levels and lipid peroxidation (MDA) levels, and the role of colchicine and vitamin E therapy on protein carbonyl group and MDA levels in serum samples of patients with BD. In this study, subjects were classified as control group, colchicine therapy group alone and colchicine and vitamin E therapy group. Protein carbonyl and MDA levels at the beginning of the study were significantly (p < 0.05) higher in both therapy groups compared with those of the control group. We found that the protein carbonyl and MDA levels at the end of the study showed no significant (p > 0.05) differences between the therapy groups and control group. These results provide some evidence for a potential effect of colchicine and vitamin E therapies on increased protein oxidation and lipid peroxidation in BD. (c) 2007 Prous Science. All rights reserved. PMID: 18040527 [PubMed - in process] ------------------------------------------------ http://en.wikipedia.org/wiki/Colchicine Colchicine is a highly poisonous natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (Autumn crocus, also known as the "Meadow saffron"). Originally used to treat rheumatic complaints and especially gout, it was also prescribed for its cathartic and emetic effects. Its present medicinal use is mainly in the treatment of gout; as well, it is being investigated for its potential use as an anti-cancer drug. It can also be used as initial treatment for pericarditis and preventing recurrences of the condition. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
From: angself on 5 Dec 2007 11:14 I was given this for the severe chostocondritis pain that I have... as it has been recently either said to be used or approved of use for that... costcondritis dang sp for most means one chostochondral joint on one side of the sternum... but for me it means both sides and in the back and the sternum as well... making it difficult to breath... and they say it is like tendinitis meaneing it needs rest to make it better, but since we breath it is a viscous cycle... then of course they were calling the awful pain upon touching any part of my rib cage was that too, but it isn't and I don't know what it is, but if you put enough pressure through my skin on any bone it is very painful especially undermy arms in the rib cage... when I wake up in the morning before any meds are working it feels like I have to keep my trunk stiff and my chest full of air just to walk. who knows... my bone density was abnormal for my age but normal within my disease... which sounds kind of stupid to me so I'm not being treated for it and a recent mri showed my bones were dehydrated... blah but after reading up on this drug I stopped taking it... I couldn't feel it helping anyway.
From: Ruth Tay on 5 Dec 2007 14:59 In article <37218cb0-5913-4a95-b932-429281a03498(a)j44g2000hsj.googlegroups.com>, angself <angself(a)gmail.com> wrote: When I have chostocondris the Doctor gives me prednisone which relieves it within hours. Isn't colchicine mostly for gout? ruth > I was given this for the severe chostocondritis pain that I have... as > it has been recently either said to be used or approved of use for > that... > > costcondritis dang sp for most means one chostochondral joint on one > side of the sternum... but for me it means both sides and in the back > and the sternum as well... making it difficult to breath... and they > say it is like tendinitis meaneing it needs rest to make it better, > but since we breath it is a viscous cycle... > > then of course they were calling the awful pain upon touching any part > of my rib cage was that too, but it isn't and I don't know what it is, > but if you put enough pressure through my skin on any bone it is very > painful especially undermy arms in the rib cage... when I wake up in > the morning before any meds are working it feels like I have to keep > my trunk stiff and my chest full of air just to walk. > > who knows... my bone density was abnormal for my age but normal within > my disease... which sounds kind of stupid to me so I'm not being > treated for it and a recent mri showed my bones were dehydrated... > blah > > but after reading up on this drug I stopped taking it... I couldn't > feel it helping anyway.
From: angself on 5 Dec 2007 17:20 On Dec 5, 1:59 pm, Ruth Tay <ruth...(a)mcn.org> wrote: > In article > <37218cb0-5913-4a95-b932-429281a03...(a)j44g2000hsj.googlegroups.com>, > > angself <angs...(a)gmail.com> wrote: > > When I have chostocondris the Doctor gives me prednisone which > relieves it within hours. Isn't colchicine mostly for gout? ruth > > > I was given this for the severe chostocondritis pain that I have... as > > it has been recently either said to be used or approved of use for > > that... > > > costcondritis dang sp for most means one chostochondral joint on one > > side of the sternum... but for me it means both sides and in the back > > and the sternum as well... making it difficult to breath... and they > > say it is like tendinitis meaneing it needs rest to make it better, > > but since we breath it is a viscous cycle... > > > then of course they were calling the awful pain upon touching any part > > of my rib cage was that too, but it isn't and I don't know what it is, > > but if you put enough pressure through my skin on any bone it is very > > painful especially undermy arms in the rib cage... when I wake up in > > the morning before any meds are working it feels like I have to keep > > my trunk stiff and my chest full of air just to walk. > > > who knows... my bone density was abnormal for my age but normal within > > my disease... which sounds kind of stupid to me so I'm not being > > treated for it and a recent mri showed my bones were dehydrated... > > blah > > > but after reading up on this drug I stopped taking it... I couldn't > > feel it helping anyway. i can't take prednisone for 2 reasons now... I have cushings and it always skyrockets my bp. but about 7 or 8 months ago maybe longer it was written in some docs journal or something like hat or approved old goat may know more... but for the most part people have said it relieved theirs very effectively.
From: Debs on 5 Dec 2007 20:08
If you have Cushings then you NEED to take a steroid like pred... Debs angself wrote: > On Dec 5, 1:59 pm, Ruth Tay <ruth...(a)mcn.org> wrote: > >>In article >><37218cb0-5913-4a95-b932-429281a03...(a)j44g2000hsj.googlegroups.com>, >> >> angself <angs...(a)gmail.com> wrote: >> >>When I have chostocondris the Doctor gives me prednisone which >>relieves it within hours. Isn't colchicine mostly for gout? ruth >> >> >>>I was given this for the severe chostocondritis pain that I have... as >>>it has been recently either said to be used or approved of use for >>>that... >> >>>costcondritis dang sp for most means one chostochondral joint on one >>>side of the sternum... but for me it means both sides and in the back >>>and the sternum as well... making it difficult to breath... and they >>>say it is like tendinitis meaneing it needs rest to make it better, >>>but since we breath it is a viscous cycle... >> >>>then of course they were calling the awful pain upon touching any part >>>of my rib cage was that too, but it isn't and I don't know what it is, >>>but if you put enough pressure through my skin on any bone it is very >>>painful especially undermy arms in the rib cage... when I wake up in >>>the morning before any meds are working it feels like I have to keep >>>my trunk stiff and my chest full of air just to walk. >> >>>who knows... my bone density was abnormal for my age but normal within >>>my disease... which sounds kind of stupid to me so I'm not being >>>treated for it and a recent mri showed my bones were dehydrated... >>>blah >> >>>but after reading up on this drug I stopped taking it... I couldn't >>>feel it helping anyway. > > > i can't take prednisone for 2 reasons now... I have cushings and it > always skyrockets my bp. > > but about 7 or 8 months ago maybe longer it was written in some docs > journal or something like hat or approved old goat may know more... > but for the most part people have said it relieved theirs very > effectively. |