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From: Rod on 7 Aug 2008 04:23
One common story here is of people having high cholesterol levels. Not
infrequently they have had problems reducing these levels and sometimes
are on statins. (Despite the possibility of nasties such as
rhabdomyolysis when hypoTs are treated with statins, doctors seem not to
do thyroid tests, or to prescribe statins anyway.)

Well, this new paper appears to push thyroid hormone even more towards
centre stage regarding dietary cholesterol.

I can't help wondering what effect low thyroid has on absorption of
plant sterols such as Flora pro.activ - currently being heavily
advertised here in the UK. It would be really great if hypoTs were not
only absorbing more cholesterol but adding plant sterols to that. (The
claim is that the plant sterols reduce cholesterol absorption. And that,
in modest doses, they are harmless.)

Also makes me wonder what effect hyperTs experience - is their
cholesterol level far too low?

Given the differences between rats and humans (yes - there are some), it
would be really good to see this research continued in appropriate forms
in humans.

================

Gastroenterology. 2008 Apr;134(4):1127-36. Epub 2008 Jan 17.

Dramatically increased intestinal absorption of cholesterol following
hypophysectomy is normalized by thyroid hormone.

Gälman C, Bonde Y, Matasconi M, Angelin B, Rudling M.

Karolinska Institute, Center for Endocrinology, Metabolism, and
Diabetes, Department of Medicine and Molecular Nutrition Unit, Center
for Nutrition and Toxicology, Karolinska University Hospital, Huddinge,
S-141 86 Stockholm, Sweden.

BACKGROUND & AIMS:
Hypopituitarism is associated with dyslipidemia, and feeding
hypophysectomized rats cholesterol induces severe hypercholesterolemia.
This study aimed to unravel further how hypophysectomy alters
cholesterol and bile acid metabolism.

METHODS:
Intact and hypophysectomized rats were studied during challenge with
dietary cholesterol and ezetimibe and upon hormonal substitution with
growth hormone, cortisone, and thyroid hormone.

RESULTS:
Five findings were established in hypophysectomized rats: (1) The
intestinal absorption of cholesterol is doubled. (2) Treatment with
ezetimibe abolishes the increases in serum and liver cholesterol. (3)
Only thyroid hormone treatment normalizes the increased absorption of
cholesterol. (4) The intestinal gene expression of cholesterol
transporters NPC1L1 and ABCG5/G8 is unaltered, whereas the hepatic
expression of ABCG5/G8 is diminished but strongly stimulated by thyroid
hormone. The latter mechanism was supported by measurements of biliary
cholesterol and of fecal neutral steroids. (5) The reduced hepatic
expression of ABCG5/G8 and Cyp7a1 was normalized by cholesterol feeding,
suggesting that other nonestablished mechanisms under pituitary control
are important to maintain rats resistant to dietary cholesterol.

CONCLUSIONS:
The intestinal absorption of dietary cholesterol is under pituitary
control largely exerted by thyroid hormone. Hepatic secretion of
cholesterol and ABCG5/G8 expression are strongly stimulated in
hypophysectomized rats during treatment with thyroid hormone.

PMID: 18395092 [PubMed - indexed for MEDLINE]

<http://www.ncbi.nlm.nih.gov/pubmed/18395092>

--
Rod

Hypothyroidism is a seriously debilitating condition with an insidious
onset.
Although common it frequently goes undiagnosed.
<www.thyromind.info> <www.thyroiduk.org> <www.altsupportthyroid.org>
From: Elizabeth on 7 Aug 2008 11:41
Rod,

Have you come across any articles about how cholesterol is improved by
thyroxine/thyroid replacement? More specifically, I'm due for a cholesterol
check but want to wait until I've been on replacement long enough to have a
good effect. I like to avoid scoldings when I can!

Thanks,
Elizabeth

"Rod" <polygonum(a)ntlworld.com> wrote in message
news:6fvpntFdb58oU1(a)mid.individual.net...
> One common story here is of people having high cholesterol levels. Not
> infrequently they have had problems reducing these levels and sometimes
> are on statins. (Despite the possibility of nasties such as rhabdomyolysis
> when hypoTs are treated with statins, doctors seem not to do thyroid
> tests, or to prescribe statins anyway.)
>
> Well, this new paper appears to push thyroid hormone even more towards
> centre stage regarding dietary cholesterol.
>
> I can't help wondering what effect low thyroid has on absorption of plant
> sterols such as Flora pro.activ - currently being heavily advertised here
> in the UK. It would be really great if hypoTs were not only absorbing more
> cholesterol but adding plant sterols to that. (The claim is that the plant
> sterols reduce cholesterol absorption. And that, in modest doses, they are
> harmless.)
>
> Also makes me wonder what effect hyperTs experience - is their cholesterol
> level far too low?
>
> Given the differences between rats and humans (yes - there are some), it
> would be really good to see this research continued in appropriate forms
> in humans.
>
> ================
>
> Gastroenterology. 2008 Apr;134(4):1127-36. Epub 2008 Jan 17.
>
> Dramatically increased intestinal absorption of cholesterol following
> hypophysectomy is normalized by thyroid hormone.
>
> G�lman C, Bonde Y, Matasconi M, Angelin B, Rudling M.
>
> Karolinska Institute, Center for Endocrinology, Metabolism, and Diabetes,
> Department of Medicine and Molecular Nutrition Unit, Center for Nutrition
> and Toxicology, Karolinska University Hospital, Huddinge, S-141 86
> Stockholm, Sweden.
>
> BACKGROUND & AIMS:
> Hypopituitarism is associated with dyslipidemia, and feeding
> hypophysectomized rats cholesterol induces severe hypercholesterolemia.
> This study aimed to unravel further how hypophysectomy alters cholesterol
> and bile acid metabolism.
>
> METHODS:
> Intact and hypophysectomized rats were studied during challenge with
> dietary cholesterol and ezetimibe and upon hormonal substitution with
> growth hormone, cortisone, and thyroid hormone.
>
> RESULTS:
> Five findings were established in hypophysectomized rats: (1) The
> intestinal absorption of cholesterol is doubled. (2) Treatment with
> ezetimibe abolishes the increases in serum and liver cholesterol. (3) Only
> thyroid hormone treatment normalizes the increased absorption of
> cholesterol. (4) The intestinal gene expression of cholesterol
> transporters NPC1L1 and ABCG5/G8 is unaltered, whereas the hepatic
> expression of ABCG5/G8 is diminished but strongly stimulated by thyroid
> hormone. The latter mechanism was supported by measurements of biliary
> cholesterol and of fecal neutral steroids. (5) The reduced hepatic
> expression of ABCG5/G8 and Cyp7a1 was normalized by cholesterol feeding,
> suggesting that other nonestablished mechanisms under pituitary control
> are important to maintain rats resistant to dietary cholesterol.
>
> CONCLUSIONS:
> The intestinal absorption of dietary cholesterol is under pituitary
> control largely exerted by thyroid hormone. Hepatic secretion of
> cholesterol and ABCG5/G8 expression are strongly stimulated in
> hypophysectomized rats during treatment with thyroid hormone.
>
> PMID: 18395092 [PubMed - indexed for MEDLINE]
>
> <http://www.ncbi.nlm.nih.gov/pubmed/18395092>
>
> --
> Rod
>
> Hypothyroidism is a seriously debilitating condition with an insidious
> onset.
> Although common it frequently goes undiagnosed.
> <www.thyromind.info> <www.thyroiduk.org> <www.altsupportthyroid.org>


From: Rod on 7 Aug 2008 12:54
Elizabeth wrote:
> Rod,
>
> Have you come across any articles about how cholesterol is improved by
> thyroxine/thyroid replacement? More specifically, I'm due for a cholesterol
> check but want to wait until I've been on replacement long enough to have a
> good effect. I like to avoid scoldings when I can!
>
> Thanks,
> Elizabeth
>
<>
>
Well, I started looking. So I went to PubMed:

<http://www.ncbi.nlm.nih.gov/sites/entrez>

and typed in "thyroxine cholesterol" - and got 78 pages of results.

Narrowed these down a bit and among the first few pages found the
follwoing which might have some relevance:

<http://www.ncbi.nlm.nih.gov/pubmed/18355770>
<http://www.ncbi.nlm.nih.gov/pubmed/17900236>
<http://www.ncbi.nlm.nih.gov/pubmed/17703499>
<http://www.ncbi.nlm.nih.gov/pubmed/17636722>
<http://www.ncbi.nlm.nih.gov/pubmed/17628531>
<http://www.ncbi.nlm.nih.gov/pubmed/17299073>
<http://www.ncbi.nlm.nih.gov/pubmed/17148561>

There will undoubtedly be dozens, possibly hundreds, more. And you could
possibly narrow the search a bit - this was a quick and dirty start.

I *highly* recommend using the "My NCBI" link to create a profile. You
can then save links to articles, have automated searches, etc. Of
course, PubMed is so big and highly featured that it takes a while to
make sense of it all.

I am no expert on PubMed (still less on thyroid issues!), but don't
hesitate to ask if you have problems. Someone might be able to help.

I also recommend that you don't ignore the old papers (not infrequently
very old) - sometimes they are gems.

Also, don't forget, there is information outside PubMed! :-)

--
Rod

Hypothyroidism is a seriously debilitating condition with an insidious
onset.
Although common it frequently goes undiagnosed.
<www.thyromind.info> <www.thyroiduk.org> <www.altsupportthyroid.org>
From: Elizabeth on 7 Aug 2008 20:45
Brilliant, thanks!!!

Elizabeth


"Rod" <polygonum(a)ntlworld.com> wrote in message
news:6g0nlrFd9nokU1(a)mid.individual.net...
> Elizabeth wrote:
>> Rod,
>>
>> Have you come across any articles about how cholesterol is improved by
>> thyroxine/thyroid replacement? More specifically, I'm due for a
>> cholesterol check but want to wait until I've been on replacement long
>> enough to have a good effect. I like to avoid scoldings when I can!
>>
>> Thanks,
>> Elizabeth
>>
> <>
>>
> Well, I started looking. So I went to PubMed:
>
> <http://www.ncbi.nlm.nih.gov/sites/entrez>
>
> and typed in "thyroxine cholesterol" - and got 78 pages of results.
>
> Narrowed these down a bit and among the first few pages found the
> follwoing which might have some relevance:
>
> <http://www.ncbi.nlm.nih.gov/pubmed/18355770>
> <http://www.ncbi.nlm.nih.gov/pubmed/17900236>
> <http://www.ncbi.nlm.nih.gov/pubmed/17703499>
> <http://www.ncbi.nlm.nih.gov/pubmed/17636722>
> <http://www.ncbi.nlm.nih.gov/pubmed/17628531>
> <http://www.ncbi.nlm.nih.gov/pubmed/17299073>
> <http://www.ncbi.nlm.nih.gov/pubmed/17148561>
>
> There will undoubtedly be dozens, possibly hundreds, more. And you could
> possibly narrow the search a bit - this was a quick and dirty start.
>
> I *highly* recommend using the "My NCBI" link to create a profile. You can
> then save links to articles, have automated searches, etc. Of course,
> PubMed is so big and highly featured that it takes a while to make sense
> of it all.
>
> I am no expert on PubMed (still less on thyroid issues!), but don't
> hesitate to ask if you have problems. Someone might be able to help.
>
> I also recommend that you don't ignore the old papers (not infrequently
> very old) - sometimes they are gems.
>
> Also, don't forget, there is information outside PubMed! :-)
>
> --
> Rod
>
> Hypothyroidism is a seriously debilitating condition with an insidious
> onset.
> Although common it frequently goes undiagnosed.
> <www.thyromind.info> <www.thyroiduk.org> <www.altsupportthyroid.org>


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