Celiac

Lithocholic acid derivatives as safer Vitamin D3 substitutes
http://www.sciencedaily.com/releases/2008/03/080314165355.htm Bile Acids As Drug Candidates ScienceDaily (Mar. 19, 2008) � Bile acid derivatives can turn on the vitamin D receptor (VDR) without causing excess calcium buildup, researchers report, a finding that could lead to vitamin D therapies for condition... 16 Apr 2008 03:28

HDACs regulate contraction by sensitizing heart muscle to calcium; might explain mercury accumulation in cardiomyopathy
For quite a while now, mercury accumulation has been observed in the heart muscle of patients with cardiomyopathy (heart failure). I believe we finally have a good explanation for why this occurs. It turns out that heart muscle contraction is directly regulated by histone acetylation. HDAC inhibitors sensiti... 15 Apr 2008 23:30

Peanut Butter Cookies
Here is a fast and easy recipe I tried last night (you old timers have probably seen it). The cookies tasted fine when they were hot, but they tasted even better when they were cold. Becca Peanut Butter Cookies 1 cup low carb peanut butter 1 cup sugar (or Splenda) 1 egg Preheat the oven to 350 F. ... 21 Apr 2008 20:35

Hookworms, anemia, autoimmunity and the HIF-1/EPO/cathelicidin pathway induced by iron deficiency
Recently published research shows that hyrdoxylase inhibitors have gastroprotective properties through the induction of HIF-1a, thus making them a potential medication for leaky gut problems [PMID 18166353, 18166352]. Low iron conditions and iron chelators like EGCG also activate HIF-1a, as does cobalt chlorid... 13 Apr 2008 23:10

Some comments about acidic vs. basic diets
I wish to refine and extend my remarks on this interesting paper. This paper indicates that chronic pain and fatigue may be due to a lack of signalling through acid-sensing ion channel 3 (ASIC3) in muscles. Testosterone is required to make that channel work, which may explain why women are more likely to get ... 12 Apr 2008 00:39

Testosterone reduces muscle pain and fatigue via ASIC3
Given the interaction of p75 with ASIC3, a receptor upregulated by acetyl-l-carnitine, I think this new result explains how ALCAR provides clinical relief for chronic fatigue sufferers (it's a shame ALCAR sends hair into catagen through the same receptor and also alters cancer risks the same way; perhaps ASIC3 ... 9 Apr 2008 00:33

Caffeine blocks the blood-brain barrier dysfunction caused by high cholesterol
Zonulin is also involved in the barrier function of the gut, especially in celiac disease. However, caffeine may block regulatory T-cells via its elevation of neutral endopeptidase. NEP blocks vasoactive intestinal polypeptide and VIP is an on signal for Tregs. Caffeine can also adversely affect circadian rh... 8 Apr 2008 22:56

Potential benefits of cathelicidin (vitamin D3) vs. sinusitis
Laryngoscope. 2008 Jan 30; [Epub ahead of print] � An Antimicrobial Peptide Modulates Epithelial Responses to Bacterial Products. Vonk MJ, Hiemstra PS, Grote JJ. From the departments of Otorhinolaryngology (m.j.v., j.j.g.) and Pulmonology (p.s.h.), Leiden University Medical Center, Leiden, The Netherlands, ... 5 Apr 2008 20:31

Review article on widespread Vitamin D3 deficiency
Altern Med Rev. 2008 Mar;13(1):6-20. � Use of vitamin D in clinical practice. Cannell JJ, Hollis BW. Director, Vitamin D Council. Correspondence address: 9100 San Gregorio Road, Atascadero, CA 93422. The recent discovery - from a meta-analysis of 18 randomized controlled trials - that supplemental cholecal... 5 Apr 2008 20:31

Mechanisms of protection against autoimmunity by alternate day fasting
Recently, two different results have indicated why intermittent fasting (aka alternate day fasting) can be so effective for autoimmune disorders. It reduces T cells in humans and now we have evidence from animal research it may also reduce B cell counts. B cells produce the antibodies that T cells attack (alt... 4 Apr 2008 21:20