From: ironjustice on
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"Dietary phytate reduced age-related aorta calcification"

Phytate reduces age-related cardiovascular calcification.
Front Biosci. 2008 May 1;13:7115-22.
Grases F, Sanchis P, Perello J, Isern B, Prieto RM, Fernandez-
Palomeque C, Saus C.
Laboratory of Renal Lithiasis Research, University Institute of Health
Sciences Research, University of Balearic Islands, Palma de Mallorca,
Spain. fgrases(a)uib.es

The aim of this research was to evaluate the effect of dietary phytate
on cardiovascular calcification in rats during aging.
Male Wistar rats (10 weeks old) were randomly assigned to four diet
groups.
The control group was fed with a balanced diet (UAR-A04) containing
phytate.
The AIN group was fed a purified diet (AIN-76A) with an undetectable
level of phytate.
The PHY group was fed with a purified diet (AIN-76A) enriched with
phytate (phytin, as the calcium magnesium salt).
The MOD group was fed with the AIN-76A diet (phytate undetectable)
enriched with MgO, inositol and CaHPO4.
At 76 weeks of age all rats were sacrificed, and the aortas, hearts,
kidneys, livers and femurs were removed for chemical analysis.
The most significant differences were found in the aorta calcium
content.
Phytate-treated rats (the control and PHY groups) had significantly
lower levels of calcium in the aorta compared to nonphytate-treated
rats (AIN and MOD groups).
The present study demonstrated that dietary phytate treatment
significantly reduced age-related aorta calcification.

PMID: 18508720


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