Butyrate for autoimmunity: HDAC inhibitors activate regulatory T-cells
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From: William Nunn on 7 Jun 2007 16:09 <myancov(a)gmail.com> wrote in message news:1178040400.281043.45010(a)o5g2000hsb.googlegroups.com... > Kofi, I appreciate your posts... please keep it coming > I don't understand all the science, but understand some of it. At least he is trying to approach his problem from a scientific way, which it should be approached from.
From: judy.n on 9 Jun 2007 10:31 I appreciate the post as well: yes some of it is complicated, but it's good information. Recently there has been a push at medical conferences to highlight the almost universal deficiency of vit D and the fact that is really acts more like a hormone than a vitamin, and that most people should get about 1000 IU/day. I've been checking vit D levels (the lab normal is 20--but the endocrinologists want the levels at 40-50): I see a lot of post menopausal women with osteoporosis, and live in the northeast, so that's how I started to check. Everyone has run low. People have felt so much better when they supplement with vit D. The optimal levels to take/day isn't known yet, but up to 10,000 units is considered safte. There was actually an article in my local paper about it a couple of days ago. So, reading about the butyrate and the interaction with vit D was interesting. Also, a friend of my daughter is suffering from Crohn's. You're right: medicine has a limited set of answers. That's why we share on this group. Sometimes you can't summarize it completely in layman's terms. Thanks for the post. Judy On Jun 7, 4:09 pm, "William Nunn" <gua...(a)yorkie123.plus.com> wrote: > <myan...(a)gmail.com> wrote in message > > news:1178040400.281043.45010(a)o5g2000hsb.googlegroups.com... > > > Kofi, I appreciate your posts... please keep it coming > > I don't understand all the science, but understand some of it. At least he > is trying to approach his problem from a scientific way, which it should be > approached from.
From: Terry Raymond on 11 Jun 2007 21:25 "judy.n" <judy.nudelman(a)gmail.com> wrote in news:1181399463.776656.11730(a)q66g2000hsg.googlegroups.com: > I appreciate the post as well: yes some of it is complicated, but it's > good information. Recently there has been a push at medical > conferences to highlight the almost universal deficiency of vit D and > the fact that is really acts more like a hormone than a vitamin, and > that most people should get about 1000 IU/day. I've been checking vit > D levels (the lab normal is 20--but the endocrinologists want the > levels at 40-50): I see a lot of post menopausal women with A year ago I tested at 18 and my doctor recommended 1000IU daily. This year I tested at 43. However, recently I read that too high a vit D level can cause calcium plaques. I understand that they are not so good if they occur in your arteries. If you are seeing 20 as an average level is that because of age or you are testing people in the northeast? What is the average test level in the south? > osteoporosis, and live in the northeast, so that's how I started to > check. Everyone has run low. People have felt so much better when they > supplement with vit D. The optimal levels to take/day isn't known yet, > but up to 10,000 units is considered safte. There was actually an > article in my local paper about it a couple of days ago. > So, reading about the butyrate and the interaction with vit D was > interesting. Also, a friend of my daughter is suffering from Crohn's. > You're right: medicine has a limited set of answers. That's why we > share on this group. Sometimes you can't summarize it completely in > layman's terms. > Thanks for the post. > Judy -- Terry =========================================================== Terry Raymond Crafted Smalltalk 80 Lazywood Ln. Tiverton, RI 02878 (401) 624-4517 traymond at craftedsmalltalk nospam dot com <http://www.craftedsmalltalk.com> ===========================================================
From: Boatkitten on 24 Jun 2007 10:38 Hi Kofi, I am late joining this discussion, but a member of the Graves_Support Yahoo board sent me the link to this page, since it gave more information about the HDAC/HAT enzymes I've been investigating for the past month. My son and I have Graves Disease (as well as numerous allergies), and I became very excited about the recent (Mar 2007) discovery that when the HDAC enzyme is turned off (or when the HAT enzyme is turned on) people with the genetic code for Graves disease (PTPN22 on the FOXP3) will not develop Graves disease! But should either of those change, the RegT cell for PTPN22 will vanish! My quest has been to search for ANYTHING that will turn off the HDAC *AND/OR* turn on the HAT. So imagine my surprise when I was pointed to your first post in this thread!!! BRILLIANT!! I'm on my way to buy some Butyrate right now....and definiately more fiber (which I already eat much of since colon cancer is a strong genetic trait in my family). Now I see the evidence that Butyrate will help with all of the problems that seem to be affecting my entire family! How do you take your Butyrate? And have you heard that mangoes are also high in Butyrate? Thanks again! BK
From: Kofi on 27 Jun 2007 02:10
In article <1182695933.522929.31600(a)q75g2000hsh.googlegroups.com>, Boatkitten <boatkitten(a)aol.com> wrote: > Hi Kofi, > > I am late joining this discussion, but a member of the Graves_Support > Yahoo board sent me the link to this page, since it gave more > information about the HDAC/HAT enzymes I've been investigating for the > past month. My son and I have Graves Disease (as well as numerous > allergies), and I became very excited about the recent (Mar 2007) > discovery that when the HDAC enzyme is turned off (or when the HAT > enzyme is turned on) people with the genetic code for Graves disease > (PTPN22 on the FOXP3) will not develop Graves disease! But should > either of those change, the RegT cell for PTPN22 will vanish! Can you send me PMIDs on these research results? I'd like to look at the abstracts. You might wish to review my postings over the last six months. I've extensively discussed the relationship between digestion and autoimmunity. In particular, you might find relief from helminths. > How do you take your Butyrate? And have you heard that mangoes are > also high in Butyrate? The oral dose used in clinical trials for Crohn's is 6g daily with meals. I take it with carnitine (which, at high doses, may affect thyroid function) to help the butyrate absorb. |