Prev: Welcome, Website, FAQ, and Posting Guidelines (2008-08-04)
Next: Mood Disorders and Thyroid
From: Rod on 6 Aug 2008 02:51
New article (abstract only, I'm afraid) which identifies a "plausible
mechanism to explain the thyroid disease-breast cancer relationship".

Breast cancer has been mentioned many times here (on a.s.t) and perhaps
this might help to prove a link.

=========

1: Crit Rev Oncol Hematol. 2008 Aug 1. [Epub ahead of print]


Role of lipid peroxidation and oxidative stress in the association
between thyroid diseases and breast cancer.Gago-Dominguez M, Castelao JE.

USC/Norris Comprehensive Cancer Center, Department of Preventive
Medicine, Keck School of Medicine of the University of Southern
California, Los Angeles, CA 90033-0800, United States; Genomic Medicine
Group, CIBERER, University of Santiago de Compostela, Galician
Foundation of Genomic Medicine, CHUS, Galicia, Spain.


Evidence is accumulating for a role of the thyroid in the natural
history of breast cancer, although no plausible mechanism has been
advanced to explain this association. We believe that the thyroid
disease-breast cancer relationship provides a unique opportunity to find
out the causes of breast cancer. Both diseases are female predominant,
with specifically identified biological pathways and genetic and
environmental determinants, and seeing them in concert provides an
opportunity to identify the most relevant mechanistic pathways. In this
communication, we advance a plausible mechanism to explain the thyroid
disease-breast cancer relationship. We specifically propose that the
reduction in risk associated with hyperthyroidism or increased levels of
thyroid hormones, or iodine, may derive from the pro-oxidant properties
of these compounds, i.e., from its ability to generate oxidative
stress-induced apoptosis. Conversely, the increased risk from
hypothyroidism may derive from its ability to inhibit this
stress-mediated apoptotic process.

PMID: 18676157 [PubMed - as supplied by publisher]

<http://www.ncbi.nlm.nih.gov/pubmed/18676157>

--
Rod

Hypothyroidism is a seriously debilitating condition with an insidious
onset.
Although common it frequently goes undiagnosed.
<www.thyromind.info> <www.thyroiduk.org> <www.altsupportthyroid.org>
From: Gail on 6 Aug 2008 04:58

Interesting Rod,

I didn't know there was a link between thyroid disease and Breast
Cancer. Seems a bit obvious really - iodine concentrates not only in
breasts but other glands as well. I've seen pictures/diagrams
somewhere that show the sites that iodine concentrates, not sure if it
was after supplementation or injection for a scan.
Maybe it would be worth doing a correlation to see whether low thyroid
from lack of iodine has a stronger association with Breast Cancer than
low thyroid from autoimmune causes - and the congenital nonexistant
thyroid would also make a good comparison .
From: Alan B. Mac Farlane on 6 Aug 2008 09:13
in article 6fsvvtFd4ci1U1(a)mid.individual.net, Rod at polygonum(a)ntlworld.com
wrote on 8/5/08 11:51 PM:

> Breast cancer has been mentioned many times here (on a.s.t) and perhaps
> this might help to prove a link.


People with thyroid disorders are already pre-cancerous.

Most go on to get cancers as they are not interested in getting better, so
they stay ill with the disease and it festers, gets worse, and they then go
from pre-cancer to cancer.

They are cancering ... period ... and it is just a matter of time for the
defense structure to kill them off as they are not good for children.

Bob Novak, Tim Russert, Tony Snow ... all love war, all love Bush, all love
lies to kill our troops ... so they are dead now.

Bush the Worst gonna die soon as well from the same thing.

He is bad for children.

Foul Mouth George Carlin ... Good for children ... lives a long time.

The Defense Structure wants to raise healthy children, and it is the reason
why it does what it does. Why you marry, why you make babies, why you love
who you love.

Hey you pick em ... and the beer vote got US here.

Grim Pills love war ... Dem Grim Pills and GOPerp Grim Pills are killing US.

Have some koolaid ... Grim Pills serving it up.

May our Jealous God the Father who makes babies with His daughters and
manifest as talking fire, smoke, serpent staff, insects, pestilence, bog
creatures, darklight, and mass casuality child killing airs keep you safe
and unmolested.

sumbuddie on da watchtower wear blind sea saidis

NOTICE: Due to Presidential Executive Orders, the National Security Agency
may have read this email without warning, warrant, or notice. They may do
this without any judicial or legislative oversight. You have no recourse nor
protection save to call for the impeachment of the current President.



sumbuddie knows wazzup

:)

From: Gail on 11 Aug 2008 11:19
Have found some very interesting information on Iodine and Breast
cancer - and also the role of Iodine in Autoimmune Thyroiditis. It
seems the low incidence of Breast Cancer in Japenese women may not be
about Soy consumption but instead about the amount of Iodine in their
diet. There's a lot more information at this site, and I think I'm
going to add some Lugol's Iodine to my supplement list. I've just put
a couple of paragraphs on each topic here with the address for the
whole article.

http://www.optimox.com/pics/Iodine/IOD-01/IOD_01.htm
"Based on an extensive review of breast cancer epidemiological
studies, R.A. Wiseman (28) came to the following conclusions: 92-96%
of breast cancer cases are sporadic; There is a single cause for the
majority of cases; The causative agent is deficiency of a
micronutrient that is depleted by a high fat diet; If such an agent is
detected, intervention studies with supplementation should lead to a
decline in the incidence of breast cancer. Several authors have
proposed that this protective micronutrient is the essential element I
(5,6,10,29,30). Some of the mechanisms by which I could prevent breast
cancer are: the antioxidant properties of iodides (31); the ability of
I to markedly enhance the excited singlet to triplet radiationless
transition (32). Reactive oxygen species causing oxidative damage to
DNA are usually excited singlet with a high energy content released
rapidly and characterized by fluorescence whereas the corresponding
triplet state releases its lower energy at a slower rate expressed as
phosphorescence. Such an effect of I would depend on its concentration
in the intra- and extracellular fluids. Other possible mechanisms
involved were reviewed by Derry (29): the apoptotic properties of I
and its ability to trigger differentiation, moving the cell cycle away
from the undifferenticated characteristic of breast cancer, for that
matter, of all cancers. The above properties of I are totally
independent of thyroid hormones. A recent study in female rats (33)
has demonstrated an effect of I deficiency independent of thyroid
hormones, on the response of the hypothalamo-pituitary-adrenal axis to
stress. There was an attenuation of this axis to stress, following I
deficiency, and this attenuation persisted after functional recovery
of the thyroid axis.

The significant increase in urine pH following I-supplementation, with
mean (± SD) values of 6.05 ± 0.69 and 7.00 ± 0.85 for pre- and post-
intervention respectively, is suggestive of increased reducing
equivalents in biological fluids. This effect could be due to the 7.5
mg of iodide ingested daily (31). However, an effect of I on the
enhancement of singlet ® triplet transition (32) would decrease the
oxydative burden of the body and such an effect would result also in
an increase of urine pH. To our knowledge, this effect of I
supplementation on urine pH has not been previously reported.

Although several extrathyroidal organs and tissues have the capability
to concentrate and organify I (34-36), the most compelling evidence
for an extra thyroidal function of I is its effects on the mammary
gland. Eskin et al have published the results of their extensive and
excellent studies on the rat model of FDB and breast cancer and the
importance of iodine as an essential element for breast normality and
for protection against FDB and breast cancer (30,37,38). The amount of
I required for breast normality in the female rats was equivalent
based on body weight, to the amounts required clinically to improve
signs and symptoms of FDB (9,10). Eskin’s findings on the protective
effect of iodine against breast cancer in the rat model were recently
confirmed by Japanese workers (39)."



http://www.optimox.com/pics/Iodine/IOD-05/IOD_05.html

VI. Iodization of Salt and Chronic Autoimmune Thyroiditis: A Proposed
Pathophysiology

"In several communities worldwide, an increased incidence of chronic
autoimmune thyroiditis was reported following implementation of
iodization of sodium chloride.80 In 1966 and 1968, Weaver, et al 81,82
from Ann Arbor, Michigan reported, "The salient histopathological
feature of the thyroid glands, removed at operation in a five-year
period before iodine prophylaxis (1915-1920), was the paucity of
lymphocytes in their parenchyma, and, more importantly, the absence of
thyroiditis of any form… It should be emphasized that the thyroid
glands prior to the use of iodized salt were devoid of lymphocytes,
and nodular colloid goiters with dense lymphocytic infiltrates were
found after the introduction of iodized salt in 1924." It is of
interest to note that prior to iodization of salt, autoimmune
thyroiditis was almost non-existent in the US, although Lugol solution
and potassium iodide were used extensively in medical practice in
amounts two orders of magnitude greater than the average daily amount
ingested from iodized salt. This suggests that inadequate iodine
intake aggravated by goitrogens, not excess iodide, was the cause of
this condition. To be discussed later, autoimmune thyroiditis cannot
be induced by inorganic iodide in laboratory animals unless combined
with goitrogens, therefore inducing iodine deficiency.

Furszyfer, et al 83 from the Mayo Clinic studied the average annual
incidence of Hashimoto's thyroiditis among women of Olmsted County,
Minnesota during three consecutive periods covering 33 years of
observation, from 1935 to 1967. They found the incidence to be higher
in woman 40 years and older versus women 39 years and less. However,
in both groups there was a progressive increase in the incidence of
Hashimoto's thyroiditis over time. During the three periods evaluated,
that is 1935-1944, 1945-1954, and 1955-1967, the average annual
incidence of Hashimoto's per 100,000 population was 2.1, 17.9, and
54.1 for women 39 years and less. For women 40 years and older, the
average annual incidence over the same three periods was 16.4, 27.4,
and 94.1. The authors commented, "From this study it appears that
there has been an increase in the incidence rate of Hashimoto's
thyroiditis in Olmsted County between 1935 and 1967… One of the more
attractive hypotheses with respect to the change in the incidence of
Hashimoto's thyroiditis (and perhaps other thyroid disorders) is that
increased ingestion of iodide (For the reader's information, they are
talking about iodization of salt) triggers the disease, but obviously,
this is not the only factor to be considered its pathogenesis."

Doctor Hashimoto's name became a household word thanks to four thyroid
glands. In 1912, pathologist H. Hashimoto published in a German
medical journal and in German,84 his histological findings in four
thyroid glands removed at surgery: numerous lymphoid follicles,
extensive connective tissue formation, diffuse round cell
infiltration, and significant changes of the acinar epithelium. He
called this pathology of the thyroid "struma lymphomatosa." At the
time of this publication, autoimmune thyroiditis was not observed in
the US population until the iodization of salt. Hashimoto's
thyroiditis is now classified as goitrous autoimmune thyroiditis
because the gland is enlarged, in distinction to atrophic autoimmune
thyroiditis where atrophy and fibrosis are predominant. Both
conditions are chronic, progressing over time to hypothyroidism in a
significant percentage of patients.71,81 It is important to point out
that the Mayo Clinic study started 10-15 years after implementation of
iodization of salt in the area. Therefore, even during the first
decade of observation, the prevalence of autoimmune thyroiditis was
already significant. Again, it must be emphasized that prior to the
implementation of iodized salt as observed by Weaver, et al, 81, 82
this pathology of the thyroid gland was not reported in the US, even
though the Lugol solution and potassium iodide were used extensively
in medical practice at that time in daily amount two orders of
magnitude greater than the average intake of iodide from table salt"

Gail.
From: Gail on 11 Aug 2008 12:19
And here's another snip:

http://www.optimox.com/pics/Iodine/IOD-10/IOD_10.htm
"We have received many comments over the last two years. Following
orthoiodosupplementation, patients have described vivid dreams,
dissipated depression, no more cold extremities, more energy and less
fatigue.

Patients have noticed an overall feeling of well-being. Patients have
noticed a loss of weight. One patient after taking four pills of
iodine lost eight pounds of fluid weight in 24 hours. We have had
patients note better bowel function. Patients who have been
constipated for over ten years have now noted daily bowel movements.
We have also had patients noted relief from leg cramps at night. In
less than 1% of all the patients treated with I, have we seen an
allergic reaction. More often than not, the allergic reaction is
hives. After treating over 1,000 patients with iodine, I have at no
time seen the Wolff-Chaikoff Effect.

Iodine induces apoptosis and inhibits cells from forming cancer. The
absence of iodine in the thyroid causes goiter(3,4). Goiter is
associated with breast cancer, stomach cancer, esophageal cancer,
ovarian cancer and endometrial cancer . It is felt by many researchers
that the absence of iodine is a promoter of cancer. I feel that those
patients with the lowest excretion rates and the highest absorption of
iodine on the iodine loading test are the ones with the highest risk
for development of cancer. From literally hundreds of phone interviews
with patients over the last two years, the levels of iodine excretion
that seem to raise the highest alarm are those in which the excretion
is somewhere around 10 mg or less per 24 hours in patients age 35 and
up. My observations at this point show that there is a definite
increase in the incidence of breast cancer, stomach cancer, ovarian
cancer or thyroid cancer. If a patient has the iodine loading test and
has an iodine excretion of 10 mg or less in a 24-hour period, I
initiate a cancer workup. In 1976, a JAMA article showed that 6% of
the female population was at risk for breast cancer (25)). Women who
received thyroid supplementation doubled their risk of breast cancer
to 12%. The age groups we used to separate the patients in Figures 1-6
were based on this article. As women get older, the risk of breast
cancer increases. In Figures 2-6 the iodine/iodide loading test shows
that the older the women are, the lower the rate of iodine excretion."

Gail.

 | 
Pages: 1
Prev: Welcome, Website, FAQ, and Posting Guidelines (2008-08-04)
Next: Mood Disorders and Thyroid