Brain Stress and Cerebral Disorders
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From: ironjustice on 20 Aug 2008 10:18 Effects of Anthocyanins on Psychological Stress-Induced Oxidative Stress and Neurotransmitter Status J. Agric. Food Chem., 56 (16), 7545–7550, 2008. Effects of Anthocyanins on Psychological Stress-Induced Oxidative Stress and Neurotransmitter Status M. Mamunur Rahman,† Takashi Ichiyanagi,‡ Tadazumi Komiyama,‡ Shinji Sato,† and Tetsuya Konishi*† Faculty of Applied Life Sciences, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Niigata 956-8603, Japan Received for review March 26, 2008. Revised manuscript received May 26, 2008. Accepted June 23, 2008. This study was supported in part by a Grant in Aid from AOA Japan Co., LTD., and also from the Uchida Science Promotion Foundation, Niigata, Japan. Abstract: There is strong evidence that oxidative stress participates in the etiology of neurodegenerative diseases such as Parkinson’s, and Alzheimer’s diseases. Moreover, emotional stress effects in the central nervous system play a vital role in homeostasis. The protective effect of anthocyanins on the cerebral oxidative stress was studied using the whiskers cut model. In mice, such treatment causes psychological or emotional distress leading to oxidative stress in tissues. To investigate the in vivo antioxidant activity of anthocyanins, an extract of Vaccinium myrtillis L., an anthocyanin mixture, was orally administered (100 mg/kg of body weight.) to mice for 7 days, and then psychological stress was assessed by cutting off their whiskers. Whisker removal increased both protein carbonyl formation and lipid peroxidation in the brain, heart, kidney, and liver. Further, the levels of oxidative markers showed regional differences in the brain. Concomitantly, dopamine neurotransmitter levels were altered in both the midbrain and the brain cortex. Orally administered anthocyanins were also active in the brain, suppressing stress-induced cerebral oxidative stress and dopamine abnormalities in distressed mice. These effects of anthocyanin treatment suggest their possible usefulness for the treatment of cerebral disorders related to oxidative stress. Keywords: Anthocyanin; antioxidant activity; psychological stress; dopamine. 10.1021/jf800930s Web Release Date: July 29, 2008 Copyright © 2008 American Chemical Society -------------------- http://www.chiro.org/nutrition/FULL/Anthocyanins.shtml From the December 2001 Issue of Nutrition Science News By Marilyn Sterling, R.D. These plant pigments are more than coloring agents for fruit juices, wine, and other beverages. They also contain an array of health- promoting benefits. Eaten in large amounts by primitive humans, anthocyanins are antioxidant flavonoids that protect many body systems. They have some of the strongest physiological effects of any plant compounds, and they are also things of beauty: anthocyanins provide pigment for pansies, petunias, and plums. (Anthocyanins are a separate class of flavonoids from proanthocyanidins, discussed in NSN 2000;5(6): 231-4.) Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |