Arthritis Wonder Drugs
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From: ironjustice on 2 Aug 2008 12:47 Could arthritis wonder drugs provide clues for all disease? 18.07.2008 Drugs that have helped treat millions of rheumatoid arthritis sufferers may hold the key to many more medical conditions, including atherosclerosis a leading cause of heart disease says the researcher who jointly invented and developed them. Professor Marc Feldmann will tell scientists attending the 2008 Congress of European Pharmacological Societies (EPHAR) hosted by the British Pharmacological Society that drugs he and colleagues helped develop have already proved successful against other autoimmune diseases. The drugs target proteins called cytokines, which are protein messaging molecules released by immune cells to alert the immune and other systems that the body is under attack from a pathogen and to initiate a protective counter-response against the infection. In autoimmune diseases, such as arthritis, we discovered that cytokines are over-produced causing the immune system to fight itself, resulting in inflammation and tissue destruction, said Professor Feldmann, from Imperial College London, who is speaking at the EPHAR 2008 conference at The University of Manchester this week. We further found that by blocking just one cytokine Tumor Necrosis Factor (TNF) alpha we were able to block all the cytokines involved in the inflammation, with remarkable clinical results. The teams research led to the development of three anti-TNF alpha drugs infliximab, etanercept and adalimumab which have had a dramatic effect on the symptoms of rheumatoid arthritis patients, protecting the joints from further deterioration in the vast majority of cases. Blocking TNF alpha has had further success in treating several more chronic inflammatory conditions, including Crohns disease, psoriasis, psoriatic arthritis, ankylosing spondylitis and ulcerative colitis. But Professor Feldmann, Head of the Kennedy Institute of Rheumatology, believes similar drugs have the potential to treat many other medical conditions and will also tell the conference about his work on atherosclerosis, a disease affecting the arterial blood vessels, commonly known as hardening of the arteries, with his colleague Dr Claudia Monaco. Their work, which has won a number of prestigious awards, has resulted in the emergence of a new branch of medicine anti-cytokine therapy and research elsewhere has showed promise in yet more conditions, including the potentially fatal acute alcoholic hepatitis. Professor Feldmann said: During the conference I will be discussing the potential therapeutic targets in tissue affected by atherosclerosis, which is caused by a chronic inflammatory response in the walls of the arteries, in large part, caused by an excessive immune response to cholesterol. I will also discuss whether it is possible even likely that cytokines play a critical role in all diseases involving multiple biological processes, thus providing therapeutic targets for all unmet medical needs. Aeron Haworth | Source: alphagalileo Further information: www.ephar.org/index_fr.htm www.ephar2008.org/ www.manchester.ac.uk http://www.innovations-report.com/html/reports/medicine_health/report-114641.html Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
From: ironjustice on 2 Aug 2008 20:00 On Aug 2, 9:47 am, "ironjust...(a)aol.com" <ironjust...(a)aol.com> wrote: by blocking just one cytokine Tumor Necrosis Factor (TNF) alpha << "Phytate Decreased TNF-alpha" The influence of phytic acid on TNF-alpha and its receptors genes' expression in colon cancer Caco-2 cells. Cholewa K, Parfiniewicz B, Bednarek I, Swiatkowska L, Jezienicka E, Kierot J, Weglarz L Acta Pol Pharm 2008 Jan-Feb; 65(1):75-9. Inositol hexaphosphate (IP6, phytic acid) is a naturally occurring carbohydrate abundantly present in high-fiber diets and it is also contained in almost all mammalian cells. It plays an important role in signal transduction, cell proliferation and differentiation. Some natural substances have been shown to elicit an impact on the expression of TNF-alpha and its receptors in cancer cells. TNF-alpha represents cytokine very often deregulated at the level of both gene expression and signal transmission through TNF-alpha receptors (TNFRI and TNFRII). The aim of the present study was to analyze the IP6 influence on the transcription of genes coding for TNF-alpha and its receptors in human colon cancer cells line Caco-2. Real-time QRT-PCR based on TaqMan methodology was applied to analyze quantitatively the transcript levels of these genes. Three concentrations (1, 2.5 and 5 mM) of IP6 were used for Caco-2 cells stimulation for 1, 6, 12 and 24 h. The results showed that IP6 modulated the expression of the listed genes at transcription level in a dose and time dependent manner. The enhanced TNFRI and decreased TNF-alpha and TNFRII transcription in Caco-2 cells stimulated for 12 h with IP6 seems to be the presumptive evidence for anti-inflammatory and antitumor activity of IP6. Acta poloniae pharmaceutica [Acta Pol Pharm] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Could arthritis wonder drugs provide clues for all disease? > 18.07.2008 > Drugs that have helped treat millions of rheumatoid arthritis > sufferers may hold the key to many more medical conditions, including > atherosclerosis a leading cause of heart disease says the > researcher who jointly invented and developed them. > > Professor Marc Feldmann will tell scientists attending the 2008 > Congress of European Pharmacological Societies (EPHAR) hosted by the > British Pharmacological Society that drugs he and colleagues helped > develop have already proved successful against other autoimmune > diseases. > > The drugs target proteins called cytokines, which are protein > messaging molecules released by immune cells to alert the immune and > other systems that the body is under attack from a pathogen and to > initiate a protective counter-response against the infection. > > In autoimmune diseases, such as arthritis, we discovered that > cytokines are over-produced causing the immune system to fight itself, > resulting in inflammation and tissue destruction, said Professor > Feldmann, from Imperial College London, who is speaking at the EPHAR > 2008 conference at The University of Manchester this week. > > We further found that by blocking just one cytokine Tumor Necrosis > Factor (TNF) alpha we were able to block all the cytokines involved > in the inflammation, with remarkable clinical results. > > The teams research led to the development of three anti-TNF alpha > drugs infliximab, etanercept and adalimumab which have had a > dramatic effect on the symptoms of rheumatoid arthritis patients, > protecting the joints from further deterioration in the vast majority > of cases. > > Blocking TNF alpha has had further success in treating several more > chronic inflammatory conditions, including Crohns disease, psoriasis, > psoriatic arthritis, ankylosing spondylitis and ulcerative colitis. > > But Professor Feldmann, Head of the Kennedy Institute of Rheumatology, > believes similar drugs have the potential to treat many other medical > conditions and will also tell the conference about his work on > atherosclerosis, a disease affecting the arterial blood vessels, > commonly known as hardening of the arteries, with his colleague Dr > Claudia Monaco. > > Their work, which has won a number of prestigious awards, has resulted > in the emergence of a new branch of medicine anti-cytokine therapy > and research elsewhere has showed promise in yet more conditions, > including the potentially fatal acute alcoholic hepatitis. > > Professor Feldmann said: During the conference I will be discussing > the potential therapeutic targets in tissue affected by > atherosclerosis, which is caused by a chronic inflammatory response in > the walls of the arteries, in large part, caused by an excessive > immune response to cholesterol. > > I will also discuss whether it is possible even likely that > cytokines play a critical role in all diseases involving multiple > biological processes, thus providing therapeutic targets for all unmet > medical needs. > > Aeron Haworth | Source: alphagalileo > Further information:www.ephar.org/index_fr.htmwww.ephar2008.org/www.manchester.ac.ukhttp://www.innovations-report.com/html/reports/medicine_health/report... > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/a3cc3 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
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