From: Kofi on
I think the lack of specific antibodies against infectious diseases may
indicate a failure of sympathetic-mediated immune responses. In M.S.,
it looks like a history of sympathetic overdrive is protective - a
previous TB infection, for example.

This study pointing to the lack of antibodies with Type I diabetes says
to me that there may be a similar failure of sympathetic responses
underlying this form of diabetes.

Ann N Y Acad Sci. 2009 Sep;1173:633-9.

Anti-infectious antibodies and autoimmune-associated autoantibodies in
patients with type I diabetes mellitus and their close family members.
Krause I, Anaya JM, Fraser A, Barzilai O, Ram M, Abad V, Arango A,
Garcia J, Shoenfeld Y.
Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer,
Israel.

Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex
interactions between genetic and environmental factors. We compared
antibody levels to various infectious agents and of
autoimmune-associated autoantibodies between Colombian T1DM patients,
their close family members and healthy controls. Significantly lower
levels of antibodies against several infectious agents were detected in
the T1DM patients. These included Helicobacter pylori (P = 0.01),
cytomegalovirus (P = 0.001), Epstein-Barr virus (P = 0.02) and
Toxoplasma (P = 0.001). T1DM patients had significantly higher levels of
IgG-anti-gliadin antibodies (P = 0.001) and IgG-antitissue
transglutaminase antibodies (P = 0.03), and a borderline association
with anticentromere antibodies (P = 0.06). The lower level of antibodies
against infectious agents in T1DM patients may be related to their
younger ages, but may also point to a protective role of those
infections in T1DM development in susceptible individuals. Our results
confirm the association between T1DM and celiac disease. A possible
association with anticentromere antibody needs further studies.

PMID: 19758209