An inflammation fighting fat
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From: Quentin Grady on 29 Oct 2005 00:59 G'day G'day Folks, Many posters are aware that SARS killed by over stimulating an inflammatory response. One relatively successful treatment was to give prednisone. Maybe the same will be true of the Asian bird flu if it manages to cross the bridge to use human to human transmission. Whatever, on a much less grand scale, it should be recognised that some foods are anti-inflammatory. Here is future possibility getting an airing. http://www.sciencenews.org/articles/20051029/food.asp It could be that the writer has the cis trans conjugated linoleic acids from grass and grain fed cattle swapped. I'd appreciates someone else's comments on this matter. Best wishes, -- Quentin Grady ^ ^ / New Zealand, >#,#< [ / \ /\ "... and the blind dog was leading." http://homepages.paradise.net.nz/quentin
From: Annette on 29 Oct 2005 10:57 "Quentin Grady" <quentin(a)paradise.net.nz> wrote in message news:h106m1dlkhpo60dqhih4gga9mol754afdc(a)4ax.com... > > > It could be that the writer has the cis trans conjugated linoleic > acids from grass and grain fed cattle swapped. I'd appreciates > someone else's comments on this matter. > > Best wishes, > > -- > Quentin Grady Hi there Quentin, My knowledge in such things is very limited to the point of being only slightly above non-existant. But, I have a recollection of you saying one time that the trans-fats found in dairy were different from the manufactured ones, in that the body has enzymes(?) that are able to do things that make it non-damaging. Is that of any help for this situation? Annette
From: RK on 29 Oct 2005 11:17 "Quentin Grady" <quentin(a)paradise.net.nz> wrote in message news:h106m1dlkhpo60dqhih4gga9mol754afdc(a)4ax.com... | | G'day G'day Folks, | | Many posters are aware that SARS killed by over stimulating an | inflammatory response. One relatively successful treatment was to | give prednisone. Maybe the same will be true of the Asian bird flu if | it manages to cross the bridge to use human to human transmission. | | Whatever, on a much less grand scale, it should be recognised that | some foods are anti-inflammatory. Here is future possibility getting | an airing. | | http://www.sciencenews.org/articles/20051029/food.asp | | It could be that the writer has the cis trans conjugated linoleic | acids from grass and grain fed cattle swapped. I'd appreciates | someone else's comments on this matter. | | Best wishes, | | -- | Quentin Grady ^ ^ / | New Zealand, >#,#< [ | / \ /\ | "... and the blind dog was leading." | | http://homepages.paradise.net.nz/quentin Well I don't know if this helps or not, but my GP doctor found that I test positive for HLA-B27. Which is associated with many auto-immune diseases. My GP also thinks that I might have Ankylosing Spondylitis as well. I know the Pain Clinic doctor diagnosed me with Sacroiliitis, and from the blood test being positive my GP now confirms the diagnosis. Sacroliliitis is inflammation of the sacroiliac joint. You can read more about it here: http://www.nlm.nih.gov/medlineplus/ency/article/003551.htm LOL so you can say, I'm the Queen of Inflamation! She did mention that if I wanted to try to adjust my insulin accordingly that I should be drinking 3-4 8oz glasses of whole milk a day to help with the carteledge (err I killed that word) and eat cheese often ... She mentioned it for the calcium which I was good on in my labs, but she felt I could use more of a natural source to help me some. I'm still waiting on the call from the Rheumatologist from the referal she gave me. Called yesterday asking since they'd not called. LOL my doctor took the day off. Good thing I wasn't dying eh? Anyhoo... HTH. RK, t1
From: Jefferson on 29 Oct 2005 11:58 Hi Quentin: > G'day G'day Folks, > > Many posters are aware that SARS killed by over stimulating an > inflammatory response. One relatively successful treatment was to > give prednisone. Maybe the same will be true of the Asian bird flu if > it manages to cross the bridge to use human to human transmission. Oxidative stress and inflammation are a big deal in type 2 diabetics. The levels of COX-2 are usually high. You have mentioned the Omega 6 to Omega 3 ratio numerous times in the past 3 years. The topic of CLA competion for the elongation and delta 5 and 6 desaturase enzymes with Omega 6s and 3s have also been mentioned. A scholar.google.com search for COX-2+type+2+diabetes+intestinal resulted in 180 finds - http://tinyurl.com/doqnr. A similar search substituting inflammation for intestinal resulted in 376 finds - http://tinyurl.com/dsf2n. I had used the minimal dose of VIOXX before it was pulled from the market. My aches and pains felt a lot better then than now. ;) Inhibition of Interleukin-1?-Induced COX-2 and EP3 Gene Expression by Sodium Salicylate Enhances Pancreatic Islet ?-Cell Function - http://diabetes.diabetesjournals.org/cgi/content/full/51/6/1772 (Note that co-author, R. Paul Robertson has written extensively on diabetic issues, including many on oxidative stress - http://tinyurl.com/alf3w.) Interleukin-1? has more sever consequences than TNF-a. Fat tissues produce a lot of TNF-a and NAC can counter some of it. NF-{KAPPA}B is involved in interleukin-1? production. Interleukin-1? is not usually found in healthy pancreatic beta cells, but is found in type 1 DM. > Whatever, on a much less grand scale, it should be recognised that > some foods are anti-inflammatory. Here is future possibility getting > an airing. > > http://www.sciencenews.org/articles/20051029/food.asp The dairy industry is big in Wisconsin, but it is possible that the reseachers at Univ. of Wisc. could be objective. > > It could be that the writer has the cis trans conjugated linoleic > acids from grass and grain fed cattle swapped. I'd appreciates > someone else's comments on this matter. The abstract will not answer your question. 10t,12c-conjugated linoleic acid inhibits lipopolysaccharide-induced cyclooxygenase expression in vitro and in vivo - http://www.jlr.org/cgi/content/abstract/46/10/2134 I capitalized some key words below to make them standout. I know it's science speak. In essence, it looks like several kinds of CLA reduce inflammation and pain. I don't recall the CLAs that are naturally occuring (and can be obtained by diet) versus those that are man-made (and may be obtained by supplements). "Previous data demonstrated that conjugated linoleic acid (CLA) reduced eicosanoid release from select organs. We hypothesized that one active CLA isomer was responsible for the reduced prostaglandin release and that the mechanism was through the inhibition of inducible cyclooxygenase-2 (COX-2). Here, we examined the effects of 10t,12c-CLA and 9c,11t-CLA on COX-2 protein/mRNA expression, prostaglandin E2 (PGE2) production, and the mechanism by which CLA affects COX-2 expression and prostaglandin release. The COX-2 PROTEIN EXPRESSION LEVEL was INHIBITED 80% by 10t, 12c-CLA and 26% by 9c,11t-CLA at 100 ?M IN VITRO. PGE2 production was decreased from 5.39 to 1.12 ng/2 x 106 cells by 10t,12c-CLA and from 5.7 to 4.5 ng/2 x 106 cells by 9c,11t-CLA at 100 ?M. Mice fed 10t,12c-CLA but not 9c,11t-CLA were found to have a 34% decrease in COX-2 protein and a 43% reduction of PGE2 release in the LUNG. 10t,12c-CLA reduced COX-2 mRNA EXPRESSION LEVEL by 30% at 100 ?M IN VITRO and by 30% in mouse LUNG IN VIVO. Reduced COX-2 mRNA was attributable to an INHIBITION of the NUCLEAR FACTOR {KAPPA}B (NF-{kappa}B) PATHWAY by 10t,12c-CLA. These data suggested that the INHIBITION of NF-{KAPPA}B was one of the mechanisms for the REDUCED COX-2 EXPRESSION and PGE2 release by 10t,12c-CLA." I suppose you read the other articles cited and linked in Science News. Frank
From: Jefferson on 29 Oct 2005 12:52
Jefferson wrote: > Interleukin-1? has more sever consequences than TNF-a. Fat tissues > produce a lot of TNF-a and NAC can counter some of it. NF-{KAPPA}B is > involved in interleukin-1? production. Interleukin-1? is not usually > found in healthy pancreatic beta cells, but is found in type 1 DM. The following is an abstract of a new article. Another version of the nut trick, first you see and then you don't. Maybe? ;) Chronic Oxidative Stress as a Central Mechanism for Glucose Toxicity in Pancreatic Islet Beta Cells in Diabetes - http://diabetes.diabetesjournals.org/cgi/content/abstract/54/11/3238 "Different degrees of ?-cell failure and apoptosis are present in type 1 and type 2 diabetes. It has been recently suggested that high glucose?induced ?-cell apoptosis in type 2 diabetes shares a final common pathway with type 1 diabetes, involving interleukin-1? (IL-1?) production by ?-cells, nuclear factor-{kappa}B (NF-{kappa}B) activation, and death via Fas-FasL. The aim of this study was to test whether human islet exposure to high glucose in vitro, or to the type 2 diabetes environment in vivo, induces IL-1? expression and consequent activation of NF-{kappa}B?dependent genes. ... The present findings suggest that high glucose in vitro, or the diabetic milieu in vivo, does not induce IL-1? production or NF-{kappa}B activation in human islets. This makes it unlikely that locally produced IL-1? is an important mediator of glucotoxicity to human islets and argues against the IL-1?NF-{kappa}B?Fas pathway as a common mediator for ?-cell death in type 1 and type 2 diabetes." Frank |