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From: Rich Murray on 29 Jul 2008 15:10
533 mostly negative reports on sucralose in 2 1/2 years (many GI
symptoms) Mark J & Cherie Yannone, Phoenix, AZ www.FoodAndDiet.com: GI
stimulation, M Kidd et al, Yale U, AJPGLP 2008.06.12: Rich Murray
2008.07.29
http://rmforall.blogspot.com/2008_07_01_archive.htm
Tuesday, July 29, 2008
http://groups.yahoo.com/group/aspartameNM/message/1555
___________________________________________________


http://www.foodanddiet.com/splenda/symptom-list.html

Food and Diet, Mark J. and Cherie Yannone
1421 E Charleston Ave
Phoenix AZ 85022
Phone 602-569-9632 foodanddiet(a)aol.com;
Site designed and maintained by webDedication webDesign Studios
© 2002-2007 webDedication webDesign Studios and Cherie Yannone.
All rights reserved

All of the symptoms listed on this page may be caused by something
other than sucralose consumption. Be certain to speak with your
physician to discuss your symptoms and to get treatment for allergies,
illnesses, diseases, or conditions that require medical attention.

Having clarified that, based upon the more than 500 stories received
from our visitors, we have compiled a list of the most frequently
reported symptoms resulting from the use of sucralose (Splenda). The
list, expanding almost monthly, may not contain your particular
symptom. That does not mean you aren't suffering side effects from
Splenda consumption, but may mean that the side effect has not been
reported often enough for us to add it to the list (yet).

* bloating
* abdominal pain
* gas, sometimes painful
* nausea
* heartburn
* diarrhea
* headaches
* migraines (severe headaches)
* heart palpitations (fluttering, irregular heartbeats)
* shortness of breath
* depression
* anxiety and panic attacks
* spaced-out or drugged sensation
* joint pain, especially in the knees
* dizziness

http://www.foodanddiet.com/splenda/story-index.html
Index 7 -- 18, from 2005.04.26 to 2006.06.21

Each of the following links will take you to an individual index
containing 25 stories from Splenda users.
Some stories are positive, as indicated by a bright yellow happy face.
Some stories are negative, as indicated by a sickly green unhappy
face.
Note that the indices start at Index 7.
Previous indices are found on our main website.

In addition, the following side effects are being reported more often,
although not with the same degree of frequency as those above:

* lone atrial fibrillation
* extreme fatigue
* muscle weakness
* tingling mouth or tongue
* tingling in fingers and hands
* numbness in the lips and tongue
* swollen lips or tongue
* swollen face
* redness or welts on face
* mouth sores
* blurred vision

If you believe you are suffering ill effects after consuming Splenda,
we strongly suggest you conduct the two-week test:

For two weeks, double-check every package label (from bottled waters
to OTC medications) to ensure you consume absolutely nothing with
Splenda (sucralose).
Not every product containing sucralose will display the now-familiar
Splenda logo, so read every label.
If, during the two-week period your symptoms stop and don't return,
try consuming something with Splenda as you did previously.
If the symptoms return, you've likely discovered the source of your
illness.
If the symptoms don't abate, worsen, or do not return with a return to
Splenda consumption, you may have another illness or problem.
In either case, be certain to speak with your physician and discuss
your suspicions about sucralose as it relates to your condition.

[ The last four stories, after which no more stories are collected,
are:

http://www.foodanddiet.com/splenda/stories-500-599/splenda-story533.html

On 18 June 2006, we received this note from E.L. concerning their use
of sucralose.

"Approximately one month ago, I drank a diet lemonade. It must have
had Splenda in it because one day later I had severe cramping and
diarrhea. It lasted for two days. At first, I thought I had a bug.

A few days ago, I drank another lemonade drink (only about 2 ounces
this time). It was so sweet and so awful I threw most of it away. One
night later, I had severe stomach cramps and diarrhea. It took two
days to get over it. I almost went to the ER I was so sick.

Now that I know it's the Splenda, I will watch what I drink.

My friend ate one piece of dietetic chocolate candy. She had diarrhea
before she could get home! She knew exactly what caused it. She didn't
even get home before it hit her!

I will not touch that stuff any more."

Thank you E.L. for sharing your story with our visitors.

If you have experienced any side effects, whether you are sure it is
Splenda or not, be sure to speak with your physician and discuss all
possibilities.

You can also use the search function at the bottom of the page to find
stories based solely on a particular side effect or symptom.

http://www.foodanddiet.com/splenda/stories-500-599/splenda-story534.html

On 19 June 2006, we received this note from L. concerning their use of
sucralose.

"I have been using Splenda for probably two years. I have always loved
it because it didn't leave an aftertaste. But it seemed every month
before my menstrual cycle my breasts would become extremely tender, so
much that it was almost unbearable. I knew that caffeine could cause
this, but I was drinking half-caf coffee and really didn't feel like I
was drinking too much to cause the breast tenderness.

I decided to experiment a little. I stopped using Splenda in my
coffee about a month ago and started using saccharin to sweeten my
coffee. I just started my cycle today. It totally caught me off-guard
because before I knew when I was going to start my cycle because of
the breast tenderness. I had NO breast tenderness at all this month!!!

I am totally shocked.

I have also been having headaches a lot in the past. So I will see if
stopping the Splenda will help that as well. Just thought I should
share my story.

Thanks so much for your website!"

http://www.foodanddiet.com/splenda/stories-500-599/splenda-story535.html

On 20 June 2006, we received this note from B. concerning their use of
sucralose.

"I was searching for a website about sucralose and found your site.

I have problems with this sucralose that are among your list. I have
experienced bloating, abdominal pain (real bad), redness on my face,
swollen itchy bumps on my face, and diarrhea. I have also had a
symptom that is not on your list: clumsiness. It's like my feet don't
go where they are supposed to go. I trip and stumble.

I know these problems are caused by the sucralose because I tested
myself. The days I drank flavored water with sucralose, I had the
symptoms. A couple of days without sucralose and the symptoms
disappeared. I tried the drinks a week later, and the symptoms
reoccurred.

I'm really disappointed because I hate the taste of regular water, but
it seems everything now has sucralose in it. When Fruit 2-0 first
came out, I experienced the above symptoms. I called the company to
ask if Splenda could be causing it or if they had any complaints of
side effects. I was told there had been no adverse effects at all.
BULL!

It's like I now haven't any choie except to be very careful of what I
eat and drink. I read every word on labels. What ever happened to just
plain sugar?! Doesn't anyone care what this stuff is doing to people?!

Thank you for your website."

http://www.foodanddiet.com/splenda/stories-500-599/splenda-story536.html

On 21 June 2006, we received this note from N.H. in Northern
California concerning their use of sucralose.

"Quite a few years ago, I was diagnosed by my physician as having
reactive hypoglycemia. My blood sugar dropped to 43 during the
testing. I struggled with that off and on over the years depending on
how careful I was about what I ate.

About three years ago, I was diagnosed as hypothyroid. I was avoiding
caffeine and taking Synthroid (50, the white ones). I was actually
feeling better than I had in a long time. I don't remember when I
first tried Splenda, but I didn't like it because it seemed to cause
my blood sugar to shoot up and then crash so I could barely stay
awake. I didn't buy anything with it, but I may have had some
occasionally at a restaurant or at someone's house.

Last Thanksgiving, I bought some flavored instant decaf coffee. When I
was drinking that I was not having the sleepy crash so I didn't
suspect the Splenda. But I was not feeling well. I was anxious and
depressed, especially in the mornings. The coffee was the only thing I
was eating or drinking that was different. When I stopped drinking the
coffee, I felt much better. I didn't associate the problem with the
Splenda, though, and thought it may have been related to the process
of removing the caffeine.

Since then, I occasionally had soda with Splenda and didn't seem to be
bothered, although as I look back, my hypoglycemia seemed worse at
times and I had symptoms with lower amounts of carbs. Last month, at
the end of the school year (I am a teacher), when I was under more
stress than usual to get everything done, I bought some sugar-free ice
cream with Splenda. The stress and the Splenda together caused real
problems. I felt terrible. I was nervous and depressed, especially in
the mornings. I could feel my heart beat and my thyroid started
working overtime, so I had to stop taking my thyroid medication. After
less than a week without Splenda, I was feeling much better, and after
a week the symptoms were gone.

I think, in my case, the Splenda aggravated the hypoglycemia. I'm not
sure why it made my thyroid work overtime, but it certainly seems that
it did." ]

http://www.foodanddiet.com/NewFiles/splenda.html
Index 1 -- 6, from 2003.12.28 to 2005.04.16
___________________________________________________


http://ajpgi.physiology.org/cgi/content/abstract/00056.2008v1

"Mechanisms by which gut luminal content regulates secretion and
motility is ill-understood.
... the artificial sweetener, sucralose, stimulated (EC50 = 9.2nM and
0.38nM)."

Am J Physiol Gastrointest Liver Physiol. 2008 Jun 12. [Epub ahead of
print]
The luminal regulation of normal and neoplastic human EC cell
serotonin release is mediated by bile salts, amines, tastants and
olfactants.
Kidd M, Modlin IM, Gustafsson BI, Drozdov I, Hauso O, Pfragner R.
Surgery, Yale University School of Medicine, New Haven, Connecticut,
United States.

Introduction:
Mechanisms by which gut luminal content regulates secretion and
motility is ill-understood.

We evaluated whether neuroendocrine enterochromaffin (EC) cells act as
luminal-sensors for a wide variety of nutrients and defined the
secretory mechanisms of this process.

Methods and Results:
Pure (98-99%) FACS-sorted human EC cells and neoplastic EC cells (KRJ-
I) were studied.

RT-PCR identified transcripts for T2R1 (bitter), OR1G1 (class II
olfactory) and trace amine (TAR1) GPCRs, and transporters for
glutamine (SNAT1/2), glucose (GLUT1/3/SGLT1) and bile salts (ABST).

Glutamine and sodium deoxycholate stimulated 5HT release (EC50 =
0.002-0.2microM; 2-fold release) but were 10-100x more potent in
neoplastic EC cells which also secreted 6-13x more 5HT.

Tastants (caffeine, tyramine, octopamine) and olfactants (thymol/
eugenol), also stimulated normal and neoplastic EC cell 5HT secretion
(EC50 = 1.2nM-2.1microM and 0.05nM-0.1microM release, respectively)
while 2-deoxyglucose and the artificial sweetener, sucralose,
stimulated (EC50 = 9.2nM and 0.38nM).

5HT release was associated with ERK phosphorylation (1.5-fold, p<0.02)
and could be inhibited by a somatostatin analogue (IC50: 10(-12)M).

Eleven secretory associated genes including the vesicle docking
inhibitor, STXBP3, were up-regulated in response to glutamine and bile
salt stimulation in neoplastic EC cells.

Targeting STXBP3 expression using antisense knockdown significantly
(p<0.05) reduced 5HT secretion.

Conclusions:
EC cells express GPRCs and transporters for luminal tastants,
olfactants, glutamine, glucose and bile salts.

Activation includes a panel of secretory genes, ERK phosphorylation
and 5HT secretion.

Luminal EC cell regulation is likely to be as important as the G cell
regulation in gastric acid secretion; development of agents to target
EC cell function is a critical therapeutic goal.

Key words: gastrointestinal, luminal, neuroendocrine, secretion,
tastant.
PMID: 18556422

Mark S. Kidd 1, mark.kidd(a)yale.edu;
Irvin M. Modlin 2*, imodlin(a)optonline.net; Telephone:
+1-203-7855429 Fax: +1-203-7374067
Bjorn I Gustafsson 3, bjorn.gustafsson(a)yale.edu;
Ignat Drozdov 1, ignat.drozdov(a)yale.edu;
Oyvind Hauso 4, oyvind.hauso(a)ntnu.no;
and Roswitha Pfragner 5 roswitha.pfragner(a)meduni-graz.at;

1 Surgery, Yale University School of Medicine, New Haven, Connecticut,
United States
2 Surgery, Yale University School of Medicine, New Haven, Connecticut,
United States; United States
3 Surgery, Yale University School of Medicine, New Haven, Connecticut,
United States; Internal Medicine, Gastroenterology, St Olavs
University Hospital HF, Trondheim, Norway
4 Molecular Biology and Cancer Research, NTNU, Trondheim, Norway
5 Institute of Pathophysiology, Centre for Molecular Medicine, Medical
University of Graz, Graz, Austria; Institute of Pathophysiology and
Immunology, Centre for Molecular Medicine, Medical University of Graz,
Graz, Austria
* To whom correspondence should be addressed. E-mail:
imodlin(a)optonline.net;
___________________________________________________


http://en.wikipedia.org/wiki/Sucralose

http://groups.yahoo.com/group/aspartameNM/message/1481
Australia official report 2001.12.10 finds arsenic impurity in
sucralose
at 15 % of USA EPA adult ADI limits for daily drinking water, also 67
%
of child lead alarm limits -- evidence for claims by D.L. Dewey and
G.N.
Ferebee petition (some typos): Murray 2007.10.25

http://groups.yahoo.com/group/aspartameNM/message/1413
sucralose, aspartame, sugar legal melee, How Sweet It Isn't, Avery
Johnson, Wall Street Journal: Murray 2007.04.06

http://groups.yahoo.com/group/aspartameNM/message/1412
sucralose (an earnest effort at a neutral summary of both sides of the
Splenda toxicity debate), Wikipedia 2007.03.26: Murray 2007.03.29

adroit PR firm Qorvis Communications, hired by Sugar Association,
coyly
sets up Citizens For Health front to attack sucralose (Splenda):
Murray 2007.03.22
http://groups.yahoo.com/group/aspartameNM/message/1411

http://groups.yahoo.com/group/aspartameNM/message/1328
Migraine from sucralose, Bigal ME & Krymchantowski AV,
Headache 2006 March; formaldehyde from 11% methanol part of
aspartame or from red wine causes same toxicity (hangover) harm:
Murray 2006.04.24

http://groups.yahoo.com/group/aspartameNM/message/1257
Comet assay tests groups of 4 mice to show sucralose genotoxicity
in stomach, colon, lung, Yu F Sasaki et al, Mutation Research 2002,
full plain text: Murray 2005.11.22

http://groups.yahoo.com/group/aspartameNM/message/1152
reply to Ferne Hudson, Tate & Lyle PLC, re Splenda (sucralose) policy:
Murray 2005.02.08
"This weekend I found a large, competent website by Mr. Mark J.
Yannone, a
programmer, who in email on 2001.01.22 reported that his seizures were
cured
by giving up aspartame. Aspartame and sucralose are only a small
fraction
of the issues listed on his voluminous site.

http://www.foodanddiet.com/ foodanddiet(a)aol.com Mark J. & Cherie
Yannone
1421 E Charleston Ave, Phoenix AZ 85022
Phone 602-569-9632 Fax 602-569-9635

http://www.foodanddiet.com/NewFiles/splenda-story-list.html lists an
ever-growing archive, now 236 reports in a year, of posts about
symptoms from sucralose -- about 10% of the posts said they had no
problems. The sophistication, size, organization, and clarity of this
site far exceeds what aspartame activists offered six years ago, as
does the amount of user information.

Here are the first titles:

"I woke up with my very first migraine ever...
There has never been any negative side effect...
I have been headache free for two weeks now...
Using Splenda for a year now with no problem...
Uncontrollable bouts with gas...
I'll continue with the Splenda...
Hot and cold flashes, but also depressed for no reason...
I plan to throw out the entire box...
It IS the sucralose making me ill...
At no point would I have ever put two-and-two together...
We recently changed our way of eating...
I can relate to the symptoms I have read...
I know I feel better now, and I know how I was feeling then...
Splenda was like a kick in the stomach...
I felt so terrible I was not even able to go to work...
My focus seems to be returning...
I'm still in awe of my experience...
I have had a whopping headache for hours now...
I had one encounter with the use of Splenda...
Splenda is not so splendid...
I truly cannot attribute negative side effects to the sweetener...
I can't believe that I have been poisoning myself ...
I also stopped losing weight after adding sucralose...
I found myself spinning into a dark depression...
I started feeling "not myself"...
I have only used Splenda a few times...
I noticed incredible fatigue and sleepiness...
I am not happy with the results...
I didn't even realize it might be the Splenda ...
I had the worst feeling...
Two weeks ago, my wife decided to use Splenda ...
What a terrible mistake!...
I have had no side effects at all...
I decided to try Splenda again...
I wanted to pass along my story about sucralose...
I started using Splenda in small doses..."

"Based upon information supplied to us by our visitors, we note the
following possible side effects from consumption of sucralose:

bloating
abdominal pain
gas
nausea
diarrhea
headaches
migraines (severe headaches)
heart palpitations (fluttering)
shortness of breath
depression or overwhelming anxiety
spaced-out or drugged sensation
joint pain
dizziness"

I notice that these are also common symptoms reported by aspartame
reactors."
___________________________________________________


"Of course, everyone chooses, as a natural priority, to enjoy peace,
joy, and love by helping to find, quickly share, and positively act
upon evidence about healthy and safe food, drink, and environment."

Rich Murray, MA Room For All rmforall(a)comcast.net
505-501-2298 1943 Otowi Road, Santa Fe, New Mexico 87505

http://RMForAll.blogspot.com new primary archive

http://groups.yahoo.com/group/aspartameNM/messages
group with 126 members, 1,555 posts in a public archive

http://groups.yahoo.com/group/aspartame/messages
group with 1,126 members, 22,843 posts in public archive
___________________________________________________
From: ferrous on 29 Jul 2008 17:39
These anecdotal accounts have no value, just read them to see that even as
individual statements they are very poor and allow no valid conclusions
based on the content itself.

During the trials to show safety, had these been common or exist at all
they would have jumped off the results. They did not.

Splenda passes through the gut unchanged and is used in such very small
amounts that the gastric symptoms are highly unlikely. Because it is 600
times sweeter then table sugar very little is used.
From: mm47 on 3 Aug 2008 10:30
On Jul 29, 5:39 pm, ferr...(a)ironcity.com wrote:
> These anecdotal accounts have no value, just read them to see that even as
> individual statements they are very poor and allow no valid conclusions
> based on the content itself.
>
> During the trials to show safety, had these been common or exist at all
> they would have jumped off the results. They did not.
>
> Splenda passes through the gut unchanged and is used in such very small
> amounts that the gastric symptoms are highly unlikely. Because it is 600
> times sweeter then table sugar very little is used.

I will not comment on your intelligence, but I am one who has had
dramatic and extreme symptoms directly resulting from Sucralose
consumption. AND NO THEY DID NOT BEGIN OVERNIGHT in my case but ended
almost overnight with the suspension of intake of this chemical. I am
not a microbiologist, a gastroenterologist, or a chemist. Reality and
truth need not YOUR verification, certainly not in this case. I wish
you luck in your struggle with them both.
mm
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